| 1 | Wed Oct 13 | at Avalanche | L2-4 | 0-1-0 | 0 PTS | Ball Arena · Denver, CO |
| 2 | Fri Oct 15 | atDevils | L3-4 (OT) | 0-1-1 | 1 PTS | Prudential Center · Newark, NJ |
| 3 | Sat Oct 16 | atPenguins | L2-5 | 0-2-1 | 1 PTS | PPG Paints Arena · Pittsburgh, PA |
| 4 | Tue Oct 19 | vsIslanders | L1-4 | 0-3-1 | 1 PTS | United Center · Chicago, IL |
| 5 | Thu Oct 21 | vsCanucks | L1-4 | 0-4-1 | 1 PTS | United Center · Chicago, IL |
| 6 | Sun Oct 24 | vsRed Wings | L3-6 | 0-5-1 | 1 PTS | United Center · Chicago, IL |
| 7 | Wed Oct 27 | vsMaple Leafs | L2-3 (OT) | 0-5-2 | 2 PTS | United Center · Chicago, IL |
| 8 | Fri Oct 29 | atHurricanes | L3-6 | 0-6-2 | 2 PTS | PNC Arena · Raleigh, NC |
| 9 | Sat Oct 30 | atBlues | L0-1 | 0-7-2 | 2 PTS | Enterprise Center · St. Louis, MO |
| 10 | Mon Nov 1 | vsSenators | W5-1 | 1-7-2 | 4 PTS | United Center · Chicago, IL |
| 11 | Wed Nov 3 | vsHurricanes | L3-4 | 1-8-2 | 4 PTS | United Center · Chicago, IL |
| 12 | Fri Nov 5 | atJets | L1-5 | 1-9-2 | 4 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 13 | Sun Nov 7 | vsPredators | W2-1 (OT) | 2-9-2 | 6 PTS | United Center · Chicago, IL |
| 14 | Tue Nov 9 | vsPenguins | W3-2 (SO) | 3-9-2 | 8 PTS | United Center · Chicago, IL |
| 15 | Fri Nov 12 | vsCoyotes | W2-1 | 4-9-2 | 10 PTS | United Center · Chicago, IL |
| 16 | Wed Nov 17 | atKraken | W4-2 | 5-9-2 | 12 PTS | Climate Pledge Arena · Seattle, WA |
| 17 | Sat Nov 20 | atOilers | L2-5 | 5-10-2 | 12 PTS | Rogers Place · Edmonton, AB |
| 18 | Sun Nov 21 | atCanucks | W1-0 | 6-10-2 | 14 PTS | Rogers Arena · Vancouver, British Columbia |
| 19 | Tue Nov 23 | atFlames | L2-5 | 6-11-2 | 14 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 20 | Fri Nov 26 | vsBlues | W3-2 (OT) | 7-11-2 | 16 PTS | United Center · Chicago, IL |
| 21 | Sun Nov 28 | vsSharks | L0-2 | 7-12-2 | 16 PTS | United Center · Chicago, IL |
| 22 | Thu Dec 2 | atCapitals | W4-3 (SO) | 8-12-2 | 18 PTS | Capital One Arena · Washington, D.C. |
| 23 | Sat Dec 4 | atRangers | L2-3 | 8-13-2 | 18 PTS | Madison Square Garden · Manhattan, NY |
| 24 | Sun Dec 5 | atIslanders | W3-2 (SO) | 9-13-2 | 20 PTS | UBS Arena · Elmont, NY |
| 25 | Tue Dec 7 | vsRangers | L2-6 | 9-14-2 | 20 PTS | United Center · Chicago, IL |
| 26 | Thu Dec 9 | atCanadiens | W2-0 | 10-14-2 | 22 PTS | Bell Centre · Montreal, QC |
| 27 | Sat Dec 11 | atMaple Leafs | L4-5 | 10-15-2 | 22 PTS | Scotiabank Arena · Toronto, ON |
| 28 | Wed Dec 15 | vsCapitals | W5-4 (OT) | 11-15-2 | 24 PTS | United Center · Chicago, IL |
| 29 | Fri Dec 17 | vsPredators | L2-3 (OT) | 11-15-3 | 25 PTS | United Center · Chicago, IL |
| 30 | Sat Dec 18 | atStars | L3-4 (OT) | 11-15-4 | 26 PTS | American Airlines Center · Dallas, TX |
| 31 | Sat Jan 1 | atPredators | L1-6 | 11-16-4 | 26 PTS | Bridgestone Arena · Nashville, TN |
| 32 | Sun Jan 2 | vsFlames | L1-5 | 11-17-4 | 26 PTS | United Center · Chicago, IL |
| 33 | Tue Jan 4 | vsAvalanche | L3-4 (OT) | 11-17-5 | 27 PTS | United Center · Chicago, IL |
| 34 | Thu Jan 6 | atCoyotes | L4-6 | 11-18-5 | 27 PTS | Mullett Arena · Tempe, AZ |
| 35 | Sat Jan 8 | atKnights | W2-1 | 12-18-5 | 29 PTS | T-Mobile Arena · Las Vegas, NV |
| 36 | Tue Jan 11 | atJackets | W4-2 | 13-18-5 | 31 PTS | Nationwide Arena · Columbus, OH |
| 37 | Thu Jan 13 | vsCanadiens | W3-2 (OT) | 14-18-5 | 33 PTS | United Center · Chicago, IL |
| 38 | Sat Jan 15 | vsDucks | W3-0 | 15-18-5 | 35 PTS | United Center · Chicago, IL |
| 39 | Mon Jan 17 | atKraken | L2-3 (SO) | 15-18-6 | 36 PTS | Climate Pledge Arena · Seattle, WA |
| 40 | Fri Jan 21 | vsWild | L1-5 | 15-19-6 | 36 PTS | United Center · Chicago, IL |
| 41 | Sat Jan 22 | atWild | L3-4 (OT) | 15-19-7 | 37 PTS | Xcel Energy Center · St. Paul, MN |
| 42 | Mon Jan 24 | atAvalanche | L0-2 | 15-20-7 | 37 PTS | Ball Arena · Denver, CO |
| 43 | Wed Jan 26 | atRed Wings | W8-5 | 16-20-7 | 39 PTS | Little Caesars Arena · Detroit, MI |
| 44 | Fri Jan 28 | vsAvalanche | L4-6 | 16-21-7 | 39 PTS | United Center · Chicago, IL |
| 45 | Mon Jan 31 | vsCanucks | L1-3 | 16-22-7 | 39 PTS | United Center · Chicago, IL |
| 46 | Wed Feb 2 | vsWild | L0-5 | 16-23-7 | 39 PTS | United Center · Chicago, IL |
| 47 | Wed Feb 9 | atOilers | W4-1 | 17-23-7 | 41 PTS | Rogers Place · Edmonton, AB |
| 48 | Sat Feb 12 | atBlues | L1-5 | 17-24-7 | 41 PTS | Enterprise Center · St. Louis, MO |
| 49 | Mon Feb 14 | atJets | W3-1 | 18-24-7 | 43 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 50 | Thu Feb 17 | vsJackets | L4-7 | 18-25-7 | 43 PTS | United Center · Chicago, IL |
| 51 | Fri Feb 18 | vsStars | L0-1 (SO) | 18-25-8 | 44 PTS | United Center · Chicago, IL |
| 52 | Sun Feb 20 | vsPanthers | L2-5 | 18-26-8 | 44 PTS | United Center · Chicago, IL |
| 53 | Fri Feb 25 | vsDevils | W8-5 | 19-26-8 | 46 PTS | United Center · Chicago, IL |
| 54 | Sun Feb 27 | vsBlues | L0-4 | 19-27-8 | 46 PTS | United Center · Chicago, IL |
| 55 | Thu Mar 3 | vsOilers | W4-3 (OT) | 20-27-8 | 48 PTS | United Center · Chicago, IL |
| 56 | Sat Mar 5 | atFlyers | L3-4 | 20-28-8 | 48 PTS | Wells Fargo Center · Philadelphia, PA |
| 57 | Sun Mar 6 | vsLightning | L3-6 | 20-29-8 | 48 PTS | United Center · Chicago, IL |
| 58 | Tue Mar 8 | vsDucks | W8-3 | 21-29-8 | 50 PTS | United Center · Chicago, IL |
| 59 | Thu Mar 10 | atBruins | L3-4 | 21-30-8 | 50 PTS | TD Garden · Boston, MA |
| 60 | Sat Mar 12 | atSenators | W6-3 | 22-30-8 | 52 PTS | Canadian Tire Centre · Ottawa, ON |
| 61 | Tue Mar 15 | vsBruins | L1-2 (OT) | 22-30-9 | 53 PTS | United Center · Chicago, IL |
| 62 | Sat Mar 19 | atWild | L1-3 | 22-31-9 | 53 PTS | Xcel Energy Center · St. Paul, MN |
| 63 | Sun Mar 20 | vsJets | L4-6 | 22-32-9 | 53 PTS | United Center · Chicago, IL |
| 64 | Wed Mar 23 | atDucks | W4-2 | 23-32-9 | 55 PTS | Honda Center · Anaheim, CA |
| 65 | Thu Mar 24 | atKings | W4-3 (SO) | 24-32-9 | 57 PTS | Crypto.com Arena · Los Angeles, CA |
| 66 | Sat Mar 26 | atKnights | L4-5 (OT) | 24-32-10 | 58 PTS | T-Mobile Arena · Las Vegas, NV |
| 67 | Mon Mar 28 | vsSabres | L5-6 | 24-33-10 | 58 PTS | United Center · Chicago, IL |
| 68 | Thu Mar 31 | atPanthers | L0-4 | 24-34-10 | 58 PTS | Amerant Bank Arena · Sunrise, FL |
| 69 | Fri Apr 1 | atLightning | L2-5 | 24-35-10 | 58 PTS | AMALIE Arena · Tampa, FL |
| 70 | Sun Apr 3 | vsCoyotes | L2-3 (OT) | 24-35-11 | 59 PTS | United Center · Chicago, IL |
| 71 | Thu Apr 7 | vsKraken | L0-2 | 24-36-11 | 59 PTS | United Center · Chicago, IL |
| 72 | Sun Apr 10 | vsStars | L4-6 | 24-37-11 | 59 PTS | United Center · Chicago, IL |
| 73 | Tue Apr 12 | vsKings | L2-5 | 24-38-11 | 59 PTS | United Center · Chicago, IL |
| 74 | Thu Apr 14 | vsSharks | W5-4 (SO) | 25-38-11 | 61 PTS | United Center · Chicago, IL |
| 75 | Sat Apr 16 | atPredators | L3-4 | 25-39-11 | 61 PTS | Bridgestone Arena · Nashville, TN |
| 76 | Mon Apr 18 | vsFlames | L2-5 | 25-40-11 | 61 PTS | United Center · Chicago, IL |
| 77 | Wed Apr 20 | atCoyotes | W4-3 (OT) | 26-40-11 | 63 PTS | Mullett Arena · Tempe, AZ |
| 78 | Thu Apr 21 | atKings | L1-4 | 26-41-11 | 63 PTS | Crypto.com Arena · Los Angeles, CA |
| 79 | Sat Apr 23 | atSharks | L1-4 | 26-42-11 | 63 PTS | SAP Center · San Jose, CA |
| 80 | Mon Apr 25 | vsFlyers | W3-1 | 27-42-11 | 65 PTS | United Center · Chicago, IL |
| 81 | Wed Apr 27 | vsKnights | W4-3 (SO) | 28-42-11 | 67 PTS | United Center · Chicago, IL |
| 82 | Fri Apr 29 | atSabres | L2-3 (OT) | 28-42-12 | 68 PTS | KeyBank Center · Buffalo, NY |
