| 1 | Tue Oct 10 | at Penguins | W4-2 | 1-0-0 | 2 PTS | PPG Paints Arena · Pittsburgh, PA |
| 2 | Wed Oct 11 | atBruins | L1-3 | 1-1-0 | 2 PTS | TD Garden · Boston, MA |
| 3 | Sat Oct 14 | atCanadiens | L2-3 | 1-2-0 | 2 PTS | Bell Centre · Montreal, QC |
| 4 | Mon Oct 16 | atMaple Leafs | W4-1 | 2-2-0 | 4 PTS | Scotiabank Arena · Toronto, ON |
| 5 | Thu Oct 19 | atAvalanche | L0-4 | 2-3-0 | 4 PTS | Ball Arena · Denver, CO |
| 6 | Sat Oct 21 | vsKnights | L3-5 | 2-4-0 | 4 PTS | United Center · Chicago, IL |
| 7 | Tue Oct 24 | vsBruins | L0-3 | 2-5-0 | 4 PTS | United Center · Chicago, IL |
| 8 | Fri Oct 27 | atKnights | W4-3 (OT) | 3-5-0 | 6 PTS | T-Mobile Arena · Las Vegas, NV |
| 9 | Mon Oct 30 | atCoyotes | L1-8 | 3-6-0 | 6 PTS | Mullett Arena · Tempe, AZ |
| 10 | Sat Nov 4 | vsPanthers | W5-2 | 4-6-0 | 8 PTS | United Center · Chicago, IL |
| 11 | Sun Nov 5 | vsDevils | L2-4 | 4-7-0 | 8 PTS | United Center · Chicago, IL |
| 12 | Thu Nov 9 | atLightning | W5-3 | 5-7-0 | 10 PTS | AMALIE Arena · Tampa, FL |
| 13 | Sun Nov 12 | atPanthers | L3-4 | 5-8-0 | 10 PTS | Amerant Bank Arena · Sunrise, FL |
| 14 | Thu Nov 16 | vsLightning | L2-4 | 5-9-0 | 10 PTS | United Center · Chicago, IL |
| 15 | Sat Nov 18 | atPredators | L2-4 | 5-10-0 | 10 PTS | Bridgestone Arena · Nashville, TN |
| 16 | Sun Nov 19 | vsSabres | L2-3 | 5-11-0 | 10 PTS | United Center · Chicago, IL |
| 17 | Wed Nov 22 | atJackets | L3-7 | 5-12-0 | 10 PTS | Nationwide Arena · Columbus, OH |
| 18 | Fri Nov 24 | vsMaple Leafs | W4-3 (OT) | 6-12-0 | 12 PTS | United Center · Chicago, IL |
| 19 | Sun Nov 26 | vsBlues | L2-4 | 6-13-0 | 12 PTS | United Center · Chicago, IL |
| 20 | Tue Nov 28 | vsKraken | W4-3 | 7-13-0 | 14 PTS | United Center · Chicago, IL |
| 21 | Thu Nov 30 | atRed Wings | L1-5 | 7-14-0 | 14 PTS | Little Caesars Arena · Detroit, MI |
| 22 | Sat Dec 2 | atJets | L1-3 | 7-15-0 | 14 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 23 | Sun Dec 3 | atWild | L1-4 | 7-16-0 | 14 PTS | Xcel Energy Center · St. Paul, MN |
| 24 | Tue Dec 5 | vsPredators | L3-4 (SO) | 7-16-1 | 15 PTS | United Center · Chicago, IL |
| 25 | Thu Dec 7 | vsDucks | W1-0 | 8-16-1 | 17 PTS | United Center · Chicago, IL |
| 26 | Sat Dec 9 | vsBlues | W3-1 | 9-16-1 | 19 PTS | United Center · Chicago, IL |
| 27 | Sun Dec 10 | vsCapitals | L2-4 | 9-17-1 | 19 PTS | United Center · Chicago, IL |
| 28 | Tue Dec 12 | atOilers | L1-4 | 9-18-1 | 19 PTS | Rogers Place · Edmonton, AB |
| 29 | Thu Dec 14 | atKraken | L1-7 | 9-19-1 | 19 PTS | Climate Pledge Arena · Seattle, WA |
| 30 | Sun Dec 17 | vsCanucks | L3-4 | 9-20-1 | 19 PTS | United Center · Chicago, IL |
| 31 | Tue Dec 19 | vsAvalanche | W3-2 | 10-20-1 | 21 PTS | United Center · Chicago, IL |
| 32 | Fri Dec 22 | vsCanadiens | L2-5 | 10-21-1 | 21 PTS | United Center · Chicago, IL |
| 33 | Sat Dec 23 | atBlues | L5-7 | 10-22-1 | 21 PTS | Enterprise Center · St. Louis, MO |
| 34 | Wed Dec 27 | vsJets | W2-1 (OT) | 11-22-1 | 23 PTS | United Center · Chicago, IL |
| 35 | Fri Dec 29 | atStars | L4-5 (OT) | 11-22-2 | 24 PTS | American Airlines Center · Dallas, TX |
| 36 | Sun Dec 31 | atStars | L1-8 | 11-23-2 | 24 PTS | American Airlines Center · Dallas, TX |
| 37 | Tue Jan 2 | atPredators | L0-3 | 11-24-2 | 24 PTS | Bridgestone Arena · Nashville, TN |
| 38 | Thu Jan 4 | atRangers | L1-4 | 11-25-2 | 24 PTS | Madison Square Garden · Manhattan, NY |
| 39 | Fri Jan 5 | atDevils | L2-4 | 11-26-2 | 24 PTS | Prudential Center · Newark, NJ |
| 40 | Sun Jan 7 | vsFlames | W4-3 | 12-26-2 | 26 PTS | United Center · Chicago, IL |
| 41 | Tue Jan 9 | vsOilers | L1-2 | 12-27-2 | 26 PTS | United Center · Chicago, IL |
| 42 | Thu Jan 11 | atJets | L1-2 | 12-28-2 | 26 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 43 | Sat Jan 13 | vsStars | L1-3 | 12-29-2 | 26 PTS | United Center · Chicago, IL |
| 44 | Tue Jan 16 | vsSharks | W2-1 (SO) | 13-29-2 | 28 PTS | United Center · Chicago, IL |
| 45 | Thu Jan 18 | atSabres | L0-3 | 13-30-2 | 28 PTS | KeyBank Center · Buffalo, NY |
| 46 | Fri Jan 19 | vsIslanders | W4-3 (OT) | 14-30-2 | 30 PTS | United Center · Chicago, IL |
| 47 | Mon Jan 22 | atCanucks | L0-2 | 14-31-2 | 30 PTS | Rogers Arena · Vancouver, British Columbia |
| 48 | Wed Jan 24 | atKraken | L2-6 | 14-32-2 | 30 PTS | Climate Pledge Arena · Seattle, WA |
| 49 | Thu Jan 25 | atOilers | L0-3 | 14-33-2 | 30 PTS | Rogers Place · Edmonton, AB |
| 50 | Sat Jan 27 | atFlames | L0-1 | 14-34-2 | 30 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 51 | Wed Feb 7 | vsWild | L1-2 | 14-35-2 | 30 PTS | United Center · Chicago, IL |
| 52 | Fri Feb 9 | vsRangers | L3-4 (OT) | 14-35-3 | 31 PTS | United Center · Chicago, IL |
| 53 | Tue Feb 13 | vsCanucks | L2-4 | 14-36-3 | 31 PTS | United Center · Chicago, IL |
| 54 | Thu Feb 15 | vsPenguins | L1-4 | 14-37-3 | 31 PTS | United Center · Chicago, IL |
| 55 | Sat Feb 17 | vsSenators | W3-2 | 15-37-3 | 33 PTS | United Center · Chicago, IL |
| 56 | Mon Feb 19 | atHurricanes | L3-6 | 15-38-3 | 33 PTS | PNC Arena · Raleigh, NC |
| 57 | Wed Feb 21 | vsFlyers | L1-3 | 15-39-3 | 33 PTS | United Center · Chicago, IL |
| 58 | Fri Feb 23 | vsJets | L2-3 (OT) | 15-39-4 | 34 PTS | United Center · Chicago, IL |
| 59 | Sun Feb 25 | vsRed Wings | L2-3 (OT) | 15-39-5 | 35 PTS | United Center · Chicago, IL |
| 60 | Thu Feb 29 | vsAvalanche | L0-5 | 15-40-5 | 35 PTS | United Center · Chicago, IL |
| 61 | Sat Mar 2 | vsJackets | L2-5 | 15-41-5 | 35 PTS | United Center · Chicago, IL |
| 62 | Mon Mar 4 | atAvalanche | L0-5 | 15-42-5 | 35 PTS | Ball Arena · Denver, CO |
| 63 | Tue Mar 5 | atCoyotes | W5-2 | 16-42-5 | 37 PTS | Mullett Arena · Tempe, AZ |
| 64 | Sat Mar 9 | atCapitals | L1-4 | 16-43-5 | 37 PTS | Capital One Arena · Washington, D.C. |
| 65 | Sun Mar 10 | vsCoyotes | W7-4 | 17-43-5 | 39 PTS | United Center · Chicago, IL |
| 66 | Tue Mar 12 | vsDucks | W7-2 | 18-43-5 | 41 PTS | United Center · Chicago, IL |
| 67 | Fri Mar 15 | vsKings | L0-5 | 18-44-5 | 41 PTS | United Center · Chicago, IL |
| 68 | Sun Mar 17 | vsSharks | W5-2 | 19-44-5 | 43 PTS | United Center · Chicago, IL |
| 69 | Tue Mar 19 | atKings | L2-6 | 19-45-5 | 43 PTS | Crypto.com Arena · Los Angeles, CA |
| 70 | Thu Mar 21 | atDucks | L0-4 | 19-46-5 | 43 PTS | Honda Center · Anaheim, CA |
| 71 | Sat Mar 23 | atSharks | W5-4 (OT) | 20-46-5 | 45 PTS | SAP Center · San Jose, CA |
| 72 | Tue Mar 26 | vsFlames | W3-1 | 21-46-5 | 47 PTS | United Center · Chicago, IL |
| 73 | Thu Mar 28 | atSenators | L0-2 | 21-47-5 | 47 PTS | Canadian Tire Centre · Ottawa, ON |
| 74 | Sat Mar 30 | atFlyers | W5-1 | 22-47-5 | 49 PTS | Wells Fargo Center · Philadelphia, PA |
| 75 | Tue Apr 2 | atIslanders | L1-2 | 22-48-5 | 49 PTS | UBS Arena · Elmont, NY |
| 76 | Sat Apr 6 | vsStars | W3-2 | 23-48-5 | 51 PTS | United Center · Chicago, IL |
| 77 | Sun Apr 7 | vsWild | L0-4 | 23-49-5 | 51 PTS | United Center · Chicago, IL |
| 78 | Wed Apr 10 | atBlues | L2-5 | 23-50-5 | 51 PTS | Enterprise Center · St. Louis, MO |
| 79 | Fri Apr 12 | vsPredators | L1-5 | 23-51-5 | 51 PTS | United Center · Chicago, IL |
| 80 | Sun Apr 14 | vsHurricanes | L2-4 | 23-52-5 | 51 PTS | United Center · Chicago, IL |
| 81 | Tue Apr 16 | atKnights | L1-3 | 23-53-5 | 51 PTS | T-Mobile Arena · Las Vegas, NV |
| 82 | Thu Apr 18 | atKings | L4-5 (OT) | 23-53-6 | 52 PTS | Crypto.com Arena · Los Angeles, CA |
