| 1 | Fri Oct 15 | vs Canucks | L4-5 (SO) | 0-0-1 | 1 PTS | Wells Fargo Center · Philadelphia, PA |
| 2 | Mon Oct 18 | vs Kraken | W6-1 | 1-0-1 | 3 PTS | Wells Fargo Center · Philadelphia, PA |
| 3 | Wed Oct 20 | vs Bruins | W6-3 | 2-0-1 | 5 PTS | Wells Fargo Center · Philadelphia, PA |
| 4 | Sat Oct 23 | vs Panthers | L2-4 | 2-1-1 | 5 PTS | Wells Fargo Center · Philadelphia, PA |
| 5 | Wed Oct 27 | at Oilers | W5-3 | 3-1-1 | 7 PTS | Rogers Place · Edmonton, AB |
| 6 | Thu Oct 28 | at Canucks | W2-1 | 4-1-1 | 9 PTS | Rogers Arena · Vancouver, British Columbia |
| 7 | Sat Oct 30 | at Flames | L0-4 | 4-2-1 | 9 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 8 | Tue Nov 2 | vs Coyotes | W3-0 | 5-2-1 | 11 PTS | Wells Fargo Center · Philadelphia, PA |
| 9 | Thu Nov 4 | at Penguins | L2-3 (OT) | 5-2-2 | 12 PTS | PPG Paints Arena · Pittsburgh, PA |
| 10 | Sat Nov 6 | at Capitals | W2-1 | 6-2-2 | 14 PTS | Capital One Arena · Washington, D.C. |
| 11 | Wed Nov 10 | vs Maple Leafs | L0-3 | 6-3-2 | 14 PTS | Wells Fargo Center · Philadelphia, PA |
| 12 | Fri Nov 12 | at Hurricanes | W2-1 | 7-3-2 | 16 PTS | PNC Arena · Raleigh, NC |
| 13 | Sat Nov 13 | at Stars | L2-5 | 7-4-2 | 16 PTS | American Airlines Center · Dallas, TX |
| 14 | Tue Nov 16 | vs Flames | W2-1 (OT) | 8-4-2 | 18 PTS | Wells Fargo Center · Philadelphia, PA |
| 15 | Thu Nov 18 | vs Lightning | L3-4 (SO) | 8-4-3 | 19 PTS | Wells Fargo Center · Philadelphia, PA |
| 16 | Sat Nov 20 | vs Bruins | L2-5 | 8-5-3 | 19 PTS | Wells Fargo Center · Philadelphia, PA |
| 17 | Tue Nov 23 | at Lightning | L0-4 | 8-6-3 | 19 PTS | AMALIE Arena · Tampa, FL |
| 18 | Wed Nov 24 | at Panthers | L1-2 (OT) | 8-6-4 | 20 PTS | Amerant Bank Arena · Sunrise, FL |
| 19 | Fri Nov 26 | vs Hurricanes | L3-6 | 8-7-4 | 20 PTS | Wells Fargo Center · Philadelphia, PA |
| 20 | Sun Nov 28 | at Devils | L2-5 | 8-8-4 | 20 PTS | Prudential Center · Newark, NJ |
| 21 | Wed Dec 1 | at Rangers | L1-4 | 8-9-4 | 20 PTS | Madison Square Garden · Manhattan, NY |
| 22 | Sun Dec 5 | vs Lightning | L1-7 | 8-10-4 | 20 PTS | Wells Fargo Center · Philadelphia, PA |
| 23 | Mon Dec 6 | vs Avalanche | L5-7 | 8-11-4 | 20 PTS | Wells Fargo Center · Philadelphia, PA |
| 24 | Wed Dec 8 | at Devils | L0-3 | 8-12-4 | 20 PTS | Prudential Center · Newark, NJ |
| 25 | Fri Dec 10 | at Knights | W4-3 | 9-12-4 | 22 PTS | T-Mobile Arena · Las Vegas, NV |
| 26 | Sat Dec 11 | at Coyotes | W5-3 | 10-12-4 | 24 PTS | Mullett Arena · Tempe, AZ |
| 27 | Tue Dec 14 | vs Devils | W6-1 | 11-12-4 | 26 PTS | Wells Fargo Center · Philadelphia, PA |
| 28 | Thu Dec 16 | at Canadiens | L2-3 (SO) | 11-12-5 | 27 PTS | Bell Centre · Montreal, QC |
| 29 | Sat Dec 18 | vs Senators | W4-3 (OT) | 12-12-5 | 29 PTS | Wells Fargo Center · Philadelphia, PA |
| 30 | Wed Dec 29 | at Kraken | W3-2 (OT) | 13-12-5 | 31 PTS | Climate Pledge Arena · Seattle, WA |
| 31 | Thu Dec 30 | at Sharks | L2-3 (OT) | 13-12-6 | 32 PTS | SAP Center · San Jose, CA |
| 32 | Sat Jan 1 | at Kings | L3-6 | 13-13-6 | 32 PTS | Crypto.com Arena · Los Angeles, CA |
| 33 | Tue Jan 4 | at Ducks | L1-4 | 13-14-6 | 32 PTS | Honda Center · Anaheim, CA |
| 34 | Thu Jan 6 | vs Penguins | L2-6 | 13-15-6 | 32 PTS | Wells Fargo Center · Philadelphia, PA |
| 35 | Sat Jan 8 | vs Sharks | L2-3 (OT) | 13-15-7 | 33 PTS | Wells Fargo Center · Philadelphia, PA |
| 36 | Thu Jan 13 | at Bruins | L2-3 | 13-16-7 | 33 PTS | TD Garden · Boston, MA |
| 37 | Sat Jan 15 | vs Rangers | L2-3 | 13-17-7 | 33 PTS | Wells Fargo Center · Philadelphia, PA |
| 38 | Mon Jan 17 | at Islanders | L1-4 | 13-18-7 | 33 PTS | UBS Arena · Elmont, NY |
| 39 | Tue Jan 18 | vs Islanders | L3-4 (SO) | 13-18-8 | 34 PTS | Wells Fargo Center · Philadelphia, PA |
| 40 | Thu Jan 20 | vs Jackets | L1-2 | 13-19-8 | 34 PTS | Wells Fargo Center · Philadelphia, PA |
| 41 | Sat Jan 22 | at Sabres | L3-6 | 13-20-8 | 34 PTS | KeyBank Center · Buffalo, NY |
| 42 | Mon Jan 24 | vs Stars | L1-3 | 13-21-8 | 34 PTS | Wells Fargo Center · Philadelphia, PA |
| 43 | Tue Jan 25 | at Islanders | L3-4 | 13-22-8 | 34 PTS | UBS Arena · Elmont, NY |
| 44 | Sat Jan 29 | vs Kings | W4-3 (OT) | 14-22-8 | 36 PTS | Wells Fargo Center · Philadelphia, PA |
| 45 | Tue Feb 1 | vs Jets | W3-1 | 15-22-8 | 38 PTS | Wells Fargo Center · Philadelphia, PA |
| 46 | Wed Feb 9 | vs Red Wings | L3-6 | 15-23-8 | 38 PTS | Wells Fargo Center · Philadelphia, PA |
| 47 | Sat Feb 12 | at Red Wings | L2-4 | 15-24-8 | 38 PTS | Little Caesars Arena · Detroit, MI |
| 48 | Tue Feb 15 | at Penguins | L4-5 (OT) | 15-24-9 | 39 PTS | PPG Paints Arena · Pittsburgh, PA |
| 49 | Thu Feb 17 | vs Capitals | L3-5 | 15-25-9 | 39 PTS | Wells Fargo Center · Philadelphia, PA |
| 50 | Mon Feb 21 | vs Hurricanes | L3-4 (OT) | 15-25-10 | 40 PTS | Wells Fargo Center · Philadelphia, PA |
| 51 | Tue Feb 22 | vs Blues | L1-4 | 15-26-10 | 40 PTS | Wells Fargo Center · Philadelphia, PA |
| 52 | Sat Feb 26 | vs Capitals | W2-1 | 16-26-10 | 42 PTS | Wells Fargo Center · Philadelphia, PA |
| 53 | Tue Mar 1 | vs Oilers | L0-3 | 16-27-10 | 42 PTS | Wells Fargo Center · Philadelphia, PA |
| 54 | Thu Mar 3 | vs Wild | L4-5 | 16-28-10 | 42 PTS | Wells Fargo Center · Philadelphia, PA |
| 55 | Sat Mar 5 | vs Blackhawks | W4-3 | 17-28-10 | 44 PTS | Wells Fargo Center · Philadelphia, PA |
| 56 | Tue Mar 8 | vs Knights | W2-1 | 18-28-10 | 46 PTS | Wells Fargo Center · Philadelphia, PA |
| 57 | Thu Mar 10 | at Panthers | L3-6 | 18-29-10 | 46 PTS | Amerant Bank Arena · Sunrise, FL |
| 58 | Sat Mar 12 | at Hurricanes | L1-3 | 18-30-10 | 46 PTS | PNC Arena · Raleigh, NC |
| 59 | Sun Mar 13 | vs Canadiens | L3-4 (OT) | 18-30-11 | 47 PTS | Wells Fargo Center · Philadelphia, PA |
| 60 | Thu Mar 17 | vs Predators | W5-4 | 19-30-11 | 49 PTS | Wells Fargo Center · Philadelphia, PA |
| 61 | Fri Mar 18 | at Senators | L1-3 | 19-31-11 | 49 PTS | Canadian Tire Centre · Ottawa, ON |
| 62 | Sun Mar 20 | vs Islanders | W2-1 | 20-31-11 | 51 PTS | Wells Fargo Center · Philadelphia, PA |
| 63 | Tue Mar 22 | at Red Wings | L3-6 | 20-32-11 | 51 PTS | Little Caesars Arena · Detroit, MI |
| 64 | Thu Mar 24 | at Blues | W5-2 | 21-32-11 | 53 PTS | Enterprise Center · St. Louis, MO |
| 65 | Fri Mar 25 | at Avalanche | L3-6 | 21-33-11 | 53 PTS | Ball Arena · Denver, CO |
| 66 | Sun Mar 27 | at Predators | L4-5 | 21-34-11 | 53 PTS | Bridgestone Arena · Nashville, TN |
| 67 | Tue Mar 29 | at Wild | L1-4 | 21-35-11 | 53 PTS | Xcel Energy Center · St. Paul, MN |
| 68 | Sat Apr 2 | vs Maple Leafs | L3-6 | 21-36-11 | 53 PTS | Wells Fargo Center · Philadelphia, PA |
| 69 | Sun Apr 3 | at Rangers | W4-3 (SO) | 22-36-11 | 55 PTS | Madison Square Garden · Manhattan, NY |
| 70 | Tue Apr 5 | vs Jackets | L2-4 | 22-37-11 | 55 PTS | Wells Fargo Center · Philadelphia, PA |
| 71 | Thu Apr 7 | at Jackets | W4-1 | 23-37-11 | 57 PTS | Nationwide Arena · Columbus, OH |
| 72 | Sat Apr 9 | vs Ducks | L3-5 | 23-38-11 | 57 PTS | Wells Fargo Center · Philadelphia, PA |
| 73 | Tue Apr 12 | at Capitals | L2-9 | 23-39-11 | 57 PTS | Capital One Arena · Washington, D.C. |
| 74 | Wed Apr 13 | vs Rangers | L0-4 | 23-40-11 | 57 PTS | Wells Fargo Center · Philadelphia, PA |
| 75 | Sat Apr 16 | at Sabres | L3-4 | 23-41-11 | 57 PTS | KeyBank Center · Buffalo, NY |
| 76 | Sun Apr 17 | vs Sabres | L3-5 | 23-42-11 | 57 PTS | Wells Fargo Center · Philadelphia, PA |
| 77 | Tue Apr 19 | at Maple Leafs | L2-5 | 23-43-11 | 57 PTS | Scotiabank Arena · Toronto, ON |
| 78 | Thu Apr 21 | at Canadiens | W6-3 | 24-43-11 | 59 PTS | Bell Centre · Montreal, QC |
| 79 | Sun Apr 24 | vs Penguins | W4-1 | 25-43-11 | 61 PTS | Wells Fargo Center · Philadelphia, PA |
| 80 | Mon Apr 25 | at Blackhawks | L1-3 | 25-44-11 | 61 PTS | United Center · Chicago, IL |
| 81 | Wed Apr 27 | at Jets | L0-4 | 25-45-11 | 61 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 82 | Fri Apr 29 | vs Senators | L2-4 | 25-46-11 | 61 PTS | Wells Fargo Center · Philadelphia, PA |