| 1 | Fri Oct 11 | at Canucks | W3-2 (SO) | 1-0-0 | 2 PTS | Rogers Arena · Vancouver, British Columbia |
| 2 | Sat Oct 12 | at Flames | L3-6 | 1-1-0 | 2 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 3 | Tue Oct 15 | at Oilers | L3-4 (OT) | 1-1-1 | 3 PTS | Rogers Place · Edmonton, AB |
| 4 | Thu Oct 17 | at Kraken | L4-6 | 1-2-1 | 3 PTS | Climate Pledge Arena · Seattle, WA |
| 5 | Sat Oct 19 | vsCanucks | L0-3 | 1-3-1 | 3 PTS | Wells Fargo Center · Philadelphia, PA |
| 6 | Tue Oct 22 | vs Capitals | L1-4 | 1-4-1 | 3 PTS | Wells Fargo Center · Philadelphia, PA |
| 7 | Wed Oct 23 | atCapitals | L3-6 | 1-5-1 | 3 PTS | Capital One Arena · Washington, D.C. |
| 8 | Sat Oct 26 | vs Wild | W7-5 | 2-5-1 | 5 PTS | Wells Fargo Center · Philadelphia, PA |
| 9 | Sun Oct 27 | vs Canadiens | L3-4 | 2-6-1 | 5 PTS | Wells Fargo Center · Philadelphia, PA |
| 10 | Tue Oct 29 | at Bruins | W2-0 | 3-6-1 | 7 PTS | TD Garden · Boston, MA |
| 11 | Thu Oct 31 | vs Blues | W2-1 | 4-6-1 | 9 PTS | Wells Fargo Center · Philadelphia, PA |
| 12 | Sat Nov 2 | vsBruins | L0-3 | 4-7-1 | 9 PTS | Wells Fargo Center · Philadelphia, PA |
| 13 | Tue Nov 5 | at Hurricanes | L4-6 | 4-8-1 | 9 PTS | PNC Arena · Raleigh, NC |
| 14 | Thu Nov 7 | at Lightning | W2-1 (SO) | 5-8-1 | 11 PTS | AMALIE Arena · Tampa, FL |
| 15 | Sat Nov 9 | at Panthers | L3-4 (SO) | 5-8-2 | 12 PTS | Amerant Bank Arena · Sunrise, FL |
| 16 | Mon Nov 11 | vs Sharks | W4-3 (SO) | 6-8-2 | 14 PTS | Wells Fargo Center · Philadelphia, PA |
| 17 | Thu Nov 14 | at Senators | W5-4 (OT) | 7-8-2 | 16 PTS | Canadian Tire Centre · Ottawa, ON |
| 18 | Sat Nov 16 | vs Sabres | W5-2 | 8-8-2 | 18 PTS | Wells Fargo Center · Philadelphia, PA |
| 19 | Mon Nov 18 | vs Avalanche | L2-3 | 8-9-2 | 18 PTS | Wells Fargo Center · Philadelphia, PA |
| 20 | Wed Nov 20 | vsHurricanes | L1-4 | 8-10-2 | 18 PTS | Wells Fargo Center · Philadelphia, PA |
| 21 | Sat Nov 23 | vs Blackhawks | W3-2 (OT) | 9-10-2 | 20 PTS | Wells Fargo Center · Philadelphia, PA |
| 22 | Mon Nov 25 | vs Knights | L4-5 (SO) | 9-10-3 | 21 PTS | Wells Fargo Center · Philadelphia, PA |
| 23 | Wed Nov 27 | at Predators | W3-2 (OT) | 10-10-3 | 23 PTS | Bridgestone Arena · Nashville, TN |
| 24 | Fri Nov 29 | vs Rangers | W3-1 | 11-10-3 | 25 PTS | Wells Fargo Center · Philadelphia, PA |
| 25 | Sat Nov 30 | atBlues | W3-2 (OT) | 12-10-3 | 27 PTS | Enterprise Center · St. Louis, MO |
| 26 | Thu Dec 5 | vsPanthers | L5-7 | 12-11-3 | 27 PTS | Wells Fargo Center · Philadelphia, PA |
| 27 | Sat Dec 7 | atBruins | L3-4 (OT) | 12-11-4 | 28 PTS | TD Garden · Boston, MA |
| 28 | Sun Dec 8 | vs Utah HC | L2-4 | 12-12-4 | 28 PTS | Wells Fargo Center · Philadelphia, PA |
| 29 | Tue Dec 10 | at Jackets | W5-3 | 13-12-4 | 30 PTS | Nationwide Arena · Columbus, OH |
| 30 | Thu Dec 12 | vs Red Wings | W4-1 | 14-12-4 | 32 PTS | Wells Fargo Center · Philadelphia, PA |
| 31 | Sat Dec 14 | atWild | L1-4 | 14-13-4 | 32 PTS | Xcel Energy Center · St. Paul, MN |
| 32 | Wed Dec 18 | atRed Wings | L4-6 | 14-14-4 | 32 PTS | Little Caesars Arena · Detroit, MI |
| 33 | Thu Dec 19 | vs Kings | L3-7 | 14-15-4 | 32 PTS | Wells Fargo Center · Philadelphia, PA |
| 34 | Sat Dec 21 | vsJackets | W5-4 (OT) | 15-15-4 | 34 PTS | Wells Fargo Center · Philadelphia, PA |
| 35 | Mon Dec 23 | at Penguins | L3-7 | 15-16-4 | 34 PTS | PPG Paints Arena · Pittsburgh, PA |
| 36 | Sat Dec 28 | at Ducks | W3-1 | 16-16-4 | 36 PTS | Honda Center · Anaheim, CA |
| 37 | Sun Dec 29 | atKings | L4-5 | 16-17-4 | 36 PTS | Crypto.com Arena · Los Angeles, CA |
| 38 | Tue Dec 31 | atSharks | W4-0 | 17-17-4 | 38 PTS | SAP Center · San Jose, CA |
| 39 | Thu Jan 2 | atKnights | L2-5 | 17-18-4 | 38 PTS | T-Mobile Arena · Las Vegas, NV |
| 40 | Sun Jan 5 | at Maple Leafs | L2-3 (OT) | 17-18-5 | 39 PTS | Scotiabank Arena · Toronto, ON |
| 41 | Tue Jan 7 | vsMaple Leafs | L2-3 | 17-19-5 | 39 PTS | Wells Fargo Center · Philadelphia, PA |
| 42 | Thu Jan 9 | vs Stars | L1-4 | 17-20-5 | 39 PTS | Wells Fargo Center · Philadelphia, PA |
| 43 | Sat Jan 11 | vsDucks | W6-0 | 18-20-5 | 41 PTS | Wells Fargo Center · Philadelphia, PA |
| 44 | Mon Jan 13 | vsPanthers | W4-3 | 19-20-5 | 43 PTS | Wells Fargo Center · Philadelphia, PA |
| 45 | Tue Jan 14 | atJackets | L2-3 (SO) | 19-20-6 | 44 PTS | Nationwide Arena · Columbus, OH |
| 46 | Thu Jan 16 | at Islanders | W5-3 | 20-20-6 | 46 PTS | UBS Arena · Elmont, NY |
| 47 | Sat Jan 18 | at Devils | W3-1 | 21-20-6 | 48 PTS | Prudential Center · Newark, NJ |
| 48 | Tue Jan 21 | vsRed Wings | W2-1 (OT) | 22-20-6 | 50 PTS | Wells Fargo Center · Philadelphia, PA |
| 49 | Thu Jan 23 | atRangers | L1-6 | 22-21-6 | 50 PTS | Madison Square Garden · Manhattan, NY |
| 50 | Fri Jan 24 | atIslanders | L1-3 | 22-22-6 | 50 PTS | UBS Arena · Elmont, NY |
| 51 | Mon Jan 27 | vsDevils | W4-2 | 23-22-6 | 52 PTS | Wells Fargo Center · Philadelphia, PA |
| 52 | Wed Jan 29 | atDevils | L0-5 | 23-23-6 | 52 PTS | Prudential Center · Newark, NJ |
| 53 | Thu Jan 30 | vsIslanders | L0-3 | 23-24-6 | 52 PTS | Wells Fargo Center · Philadelphia, PA |
| 54 | Sun Feb 2 | atAvalanche | L0-2 | 23-25-6 | 52 PTS | Ball Arena · Denver, CO |
| 55 | Tue Feb 4 | atUtah HC | L2-3 (OT) | 23-25-7 | 53 PTS | Delta Center · Salt Lake City, UT |
| 56 | Thu Feb 6 | vsCapitals | L3-4 | 23-26-7 | 53 PTS | Wells Fargo Center · Philadelphia, PA |
| 57 | Sat Feb 8 | vsPenguins | W3-2 | 24-26-7 | 55 PTS | Wells Fargo Center · Philadelphia, PA |
| 58 | Sat Feb 22 | vsOilers | W6-3 | 25-26-7 | 57 PTS | Wells Fargo Center · Philadelphia, PA |
Jets