| 1 | Thu Oct 13 | vs Devils | W5-2 | 1-0-0 | 2 PTS | Wells Fargo Center · Philadelphia, PA |
| 2 | Sat Oct 15 | vsCanucks | W3-2 | 2-0-0 | 4 PTS | Wells Fargo Center · Philadelphia, PA |
| 3 | Tue Oct 18 | atLightning | W3-2 | 3-0-0 | 6 PTS | AMALIE Arena · Tampa, FL |
| 4 | Wed Oct 19 | atPanthers | L3-4 | 3-1-0 | 6 PTS | Amerant Bank Arena · Sunrise, FL |
| 5 | Sat Oct 22 | atPredators | W3-1 | 4-1-0 | 8 PTS | Bridgestone Arena · Nashville, TN |
| 6 | Sun Oct 23 | vsSharks | L0-3 | 4-2-0 | 8 PTS | Wells Fargo Center · Philadelphia, PA |
| 7 | Thu Oct 27 | vsPanthers | W4-3 | 5-2-0 | 10 PTS | Wells Fargo Center · Philadelphia, PA |
| 8 | Sat Oct 29 | vsHurricanes | L3-4 (OT) | 5-2-1 | 11 PTS | Wells Fargo Center · Philadelphia, PA |
| 9 | Tue Nov 1 | atRangers | L0-1 (OT) | 5-2-2 | 12 PTS | Madison Square Garden · Manhattan, NY |
| 10 | Wed Nov 2 | atMaple Leafs | L2-5 | 5-3-2 | 12 PTS | Scotiabank Arena · Toronto, ON |
| 11 | Sat Nov 5 | atSenators | W2-1 | 6-3-2 | 14 PTS | Canadian Tire Centre · Ottawa, ON |
| 12 | Tue Nov 8 | vsBlues | W5-1 | 7-3-2 | 16 PTS | Wells Fargo Center · Philadelphia, PA |
| 13 | Thu Nov 10 | atJackets | L2-5 | 7-4-2 | 16 PTS | Nationwide Arena · Columbus, OH |
| 14 | Sat Nov 12 | vsSenators | L1-4 | 7-5-2 | 16 PTS | Wells Fargo Center · Philadelphia, PA |
| 15 | Sun Nov 13 | vsStars | L1-5 | 7-6-2 | 16 PTS | Wells Fargo Center · Philadelphia, PA |
| 16 | Tue Nov 15 | atJackets | L4-5 (OT) | 7-6-3 | 17 PTS | Nationwide Arena · Columbus, OH |
| 17 | Thu Nov 17 | atBruins | L1-4 | 7-7-3 | 17 PTS | TD Garden · Boston, MA |
| 18 | Sat Nov 19 | atCanadiens | L4-5 (SO) | 7-7-4 | 18 PTS | Bell Centre · Montreal, QC |
| 19 | Mon Nov 21 | vsFlames | L2-5 | 7-8-4 | 18 PTS | Wells Fargo Center · Philadelphia, PA |
| 20 | Wed Nov 23 | atCapitals | L2-3 (OT) | 7-8-5 | 19 PTS | Capital One Arena · Washington, D.C. |
| 21 | Fri Nov 25 | vsPenguins | L1-4 | 7-9-5 | 19 PTS | Wells Fargo Center · Philadelphia, PA |
| 22 | Sat Nov 26 | atIslanders | L2-5 | 7-10-5 | 19 PTS | UBS Arena · Elmont, NY |
| 23 | Tue Nov 29 | vsIslanders | W3-1 | 8-10-5 | 21 PTS | Wells Fargo Center · Philadelphia, PA |
| 24 | Thu Dec 1 | vsLightning | L1-4 | 8-11-5 | 21 PTS | Wells Fargo Center · Philadelphia, PA |
| 25 | Sat Dec 3 | vsDevils | L2-3 | 8-12-5 | 21 PTS | Wells Fargo Center · Philadelphia, PA |
| 26 | Mon Dec 5 | vsAvalanche | W5-3 | 9-12-5 | 23 PTS | Wells Fargo Center · Philadelphia, PA |
| 27 | Wed Dec 7 | vsCapitals | L1-4 | 9-13-5 | 23 PTS | Wells Fargo Center · Philadelphia, PA |
| 28 | Fri Dec 9 | atKnights | L1-2 (OT) | 9-13-6 | 24 PTS | T-Mobile Arena · Las Vegas, NV |
| 29 | Sun Dec 11 | atCoyotes | L4-5 (OT) | 9-13-7 | 25 PTS | Mullett Arena · Tempe, AZ |
| 30 | Tue Dec 13 | atAvalanche | L2-3 | 9-14-7 | 25 PTS | Ball Arena · Denver, CO |
| 31 | Thu Dec 15 | atDevils | W2-1 | 10-14-7 | 27 PTS | Prudential Center · Newark, NJ |
| 32 | Sat Dec 17 | vsRangers | L3-6 | 10-15-7 | 27 PTS | Wells Fargo Center · Philadelphia, PA |
| 33 | Tue Dec 20 | vsJackets | W5-3 | 11-15-7 | 29 PTS | Wells Fargo Center · Philadelphia, PA |
| 34 | Thu Dec 22 | atMaple Leafs | L3-4 | 11-16-7 | 29 PTS | Scotiabank Arena · Toronto, ON |
| 35 | Fri Dec 23 | atHurricanes | L5-6 | 11-17-7 | 29 PTS | PNC Arena · Raleigh, NC |
| 36 | Thu Dec 29 | atSharks | W4-3 (OT) | 12-17-7 | 31 PTS | SAP Center · San Jose, CA |
| 37 | Sat Dec 31 | atKings | W4-2 | 13-17-7 | 33 PTS | Crypto.com Arena · Los Angeles, CA |
| 38 | Mon Jan 2 | atDucks | W4-1 | 14-17-7 | 35 PTS | Honda Center · Anaheim, CA |
| 39 | Thu Jan 5 | vsCoyotes | W6-2 | 15-17-7 | 37 PTS | Wells Fargo Center · Philadelphia, PA |
| 40 | Sun Jan 8 | vsMaple Leafs | L2-6 | 15-18-7 | 37 PTS | Wells Fargo Center · Philadelphia, PA |
| 41 | Mon Jan 9 | atSabres | W4-0 | 16-18-7 | 39 PTS | KeyBank Center · Buffalo, NY |
| 42 | Wed Jan 11 | vsCapitals | W5-3 | 17-18-7 | 41 PTS | Wells Fargo Center · Philadelphia, PA |
| 43 | Sat Jan 14 | atCapitals | W3-1 | 18-18-7 | 43 PTS | Capital One Arena · Washington, D.C. |
| 44 | Mon Jan 16 | atBruins | L0-6 | 18-19-7 | 43 PTS | TD Garden · Boston, MA |
| 45 | Tue Jan 17 | vsDucks | W5-2 | 19-19-7 | 45 PTS | Wells Fargo Center · Philadelphia, PA |
| 46 | Thu Jan 19 | vsBlackhawks | L1-4 | 19-20-7 | 45 PTS | Wells Fargo Center · Philadelphia, PA |
| 47 | Sat Jan 21 | atRed Wings | W2-1 | 20-20-7 | 47 PTS | Little Caesars Arena · Detroit, MI |
| 48 | Sun Jan 22 | vsJets | L3-5 | 20-21-7 | 47 PTS | Wells Fargo Center · Philadelphia, PA |
| 49 | Tue Jan 24 | vsKings | L3-4 (OT) | 20-21-8 | 48 PTS | Wells Fargo Center · Philadelphia, PA |
| 50 | Thu Jan 26 | atWild | L2-3 (OT) | 20-21-9 | 49 PTS | Xcel Energy Center · St. Paul, MN |
| 51 | Sat Jan 28 | atJets | W4-0 | 21-21-9 | 51 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 52 | Mon Feb 6 | vsIslanders | L1-2 | 21-22-9 | 51 PTS | Wells Fargo Center · Philadelphia, PA |
| 53 | Thu Feb 9 | vsOilers | W2-1 (SO) | 22-22-9 | 53 PTS | Wells Fargo Center · Philadelphia, PA |
| 54 | Sat Feb 11 | vsPredators | L1-2 (OT) | 22-22-10 | 54 PTS | Wells Fargo Center · Philadelphia, PA |
| 55 | Sun Feb 12 | vsKraken | L3-4 | 22-23-10 | 54 PTS | Wells Fargo Center · Philadelphia, PA |
| 56 | Thu Feb 16 | atKraken | L2-6 | 22-24-10 | 54 PTS | Climate Pledge Arena · Seattle, WA |
| 57 | Sat Feb 18 | atCanucks | L2-6 | 22-25-10 | 54 PTS | Rogers Arena · Vancouver, British Columbia |
| 58 | Mon Feb 20 | atFlames | W4-3 | 23-25-10 | 56 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 59 | Tue Feb 21 | atOilers | L2-4 | 23-26-10 | 56 PTS | Rogers Place · Edmonton, AB |
| 60 | Fri Feb 24 | vsCanadiens | L2-5 | 23-27-10 | 56 PTS | Wells Fargo Center · Philadelphia, PA |
| 61 | Sat Feb 25 | atDevils | L0-7 | 23-28-10 | 56 PTS | Prudential Center · Newark, NJ |
| 62 | Wed Mar 1 | vsRangers | L2-3 (OT) | 23-28-11 | 57 PTS | Wells Fargo Center · Philadelphia, PA |
| 63 | Sun Mar 5 | vsRed Wings | W3-1 | 24-28-11 | 59 PTS | Wells Fargo Center · Philadelphia, PA |
| 64 | Tue Mar 7 | atLightning | L2-5 | 24-29-11 | 59 PTS | AMALIE Arena · Tampa, FL |
| 65 | Thu Mar 9 | atHurricanes | L0-1 | 24-30-11 | 59 PTS | PNC Arena · Raleigh, NC |
| 66 | Sat Mar 11 | atPenguins | L1-5 | 24-31-11 | 59 PTS | PPG Paints Arena · Pittsburgh, PA |
| 67 | Tue Mar 14 | vsKnights | L3-5 | 24-32-11 | 59 PTS | Wells Fargo Center · Philadelphia, PA |
| 68 | Fri Mar 17 | vsSabres | W5-2 | 25-32-11 | 61 PTS | Wells Fargo Center · Philadelphia, PA |
| 69 | Sat Mar 18 | vsHurricanes | L4-5 (OT) | 25-32-12 | 62 PTS | Wells Fargo Center · Philadelphia, PA |
| 70 | Tue Mar 21 | vsPanthers | W6-3 | 26-32-12 | 64 PTS | Wells Fargo Center · Philadelphia, PA |
| 71 | Thu Mar 23 | vsWild | W5-4 (SO) | 27-32-12 | 66 PTS | Wells Fargo Center · Philadelphia, PA |
| 72 | Sat Mar 25 | vsRed Wings | W3-0 | 28-32-12 | 68 PTS | Wells Fargo Center · Philadelphia, PA |
| 73 | Tue Mar 28 | vsCanadiens | W3-2 | 29-32-12 | 70 PTS | Wells Fargo Center · Philadelphia, PA |
| 74 | Thu Mar 30 | atSenators | L4-5 (OT) | 29-32-13 | 71 PTS | Canadian Tire Centre · Ottawa, ON |
| 75 | Sat Apr 1 | vsSabres | L3-6 | 29-33-13 | 71 PTS | Wells Fargo Center · Philadelphia, PA |
| 76 | Sun Apr 2 | atPenguins | L2-4 | 29-34-13 | 71 PTS | PPG Paints Arena · Pittsburgh, PA |
| 77 | Tue Apr 4 | atBlues | L2-4 | 29-35-13 | 71 PTS | Enterprise Center · St. Louis, MO |
| 78 | Thu Apr 6 | atStars | L1-4 | 29-36-13 | 71 PTS | American Airlines Center · Dallas, TX |
| 79 | Sat Apr 8 | atIslanders | L0-4 | 29-37-13 | 71 PTS | UBS Arena · Elmont, NY |
| 80 | Sun Apr 9 | vsBruins | L3-5 | 29-38-13 | 71 PTS | Wells Fargo Center · Philadelphia, PA |
| 81 | Tue Apr 11 | vsJackets | W4-3 (OT) | 30-38-13 | 73 PTS | Wells Fargo Center · Philadelphia, PA |
| 82 | Thu Apr 13 | atBlackhawks | W5-4 (OT) | 31-38-13 | 75 PTS | United Center · Chicago, IL |
