| 1 | Thu Oct 12 | at Jackets | W4-2 | 1-0-0 | 2 PTS | Nationwide Arena · Columbus, OH |
| 2 | Sat Oct 14 | atSenators | L2-5 | 1-1-0 | 2 PTS | Canadian Tire Centre · Ottawa, ON |
| 3 | Tue Oct 17 | vsCanucks | W2-0 | 2-1-0 | 4 PTS | Wells Fargo Center · Philadelphia, PA |
| 4 | Thu Oct 19 | vsOilers | W4-1 | 3-1-0 | 6 PTS | Wells Fargo Center · Philadelphia, PA |
| 5 | Sat Oct 21 | atStars | L4-5 (OT) | 3-1-1 | 7 PTS | American Airlines Center · Dallas, TX |
| 6 | Tue Oct 24 | atKnights | L2-3 | 3-2-1 | 7 PTS | T-Mobile Arena · Las Vegas, NV |
| 7 | Thu Oct 26 | vsWild | W6-2 | 4-2-1 | 9 PTS | Wells Fargo Center · Philadelphia, PA |
| 8 | Sat Oct 28 | vsDucks | L4-7 | 4-3-1 | 9 PTS | Wells Fargo Center · Philadelphia, PA |
| 9 | Mon Oct 30 | vsHurricanes | L2-3 | 4-4-1 | 9 PTS | Wells Fargo Center · Philadelphia, PA |
| 10 | Wed Nov 1 | vsSabres | L2-5 | 4-5-1 | 9 PTS | Wells Fargo Center · Philadelphia, PA |
| 11 | Fri Nov 3 | atSabres | W5-1 | 5-5-1 | 11 PTS | KeyBank Center · Buffalo, NY |
| 12 | Sat Nov 4 | vsKings | L0-5 | 5-6-1 | 11 PTS | Wells Fargo Center · Philadelphia, PA |
| 13 | Tue Nov 7 | atSharks | L1-2 | 5-7-1 | 11 PTS | SAP Center · San Jose, CA |
| 14 | Fri Nov 10 | atDucks | W6-3 | 6-7-1 | 13 PTS | Honda Center · Anaheim, CA |
| 15 | Sat Nov 11 | atKings | W4-2 | 7-7-1 | 15 PTS | Crypto.com Arena · Los Angeles, CA |
| 16 | Wed Nov 15 | atHurricanes | W3-1 | 8-7-1 | 17 PTS | PNC Arena · Raleigh, NC |
| 17 | Sat Nov 18 | vsKnights | W4-3 (OT) | 9-7-1 | 19 PTS | Wells Fargo Center · Philadelphia, PA |
| 18 | Sun Nov 19 | vsJackets | W5-2 | 10-7-1 | 21 PTS | Wells Fargo Center · Philadelphia, PA |
| 19 | Wed Nov 22 | atIslanders | L2-3 | 10-8-1 | 21 PTS | UBS Arena · Elmont, NY |
| 20 | Fri Nov 24 | vsRangers | L1-3 | 10-9-1 | 21 PTS | Wells Fargo Center · Philadelphia, PA |
| 21 | Sat Nov 25 | atIslanders | W1-0 (SO) | 11-9-1 | 23 PTS | UBS Arena · Elmont, NY |
| 22 | Tue Nov 28 | vsHurricanes | L1-4 | 11-10-1 | 23 PTS | Wells Fargo Center · Philadelphia, PA |
| 23 | Thu Nov 30 | vsDevils | L3-4 (OT) | 11-10-2 | 24 PTS | Wells Fargo Center · Philadelphia, PA |
| 24 | Sat Dec 2 | atPenguins | W4-3 (SO) | 12-10-2 | 26 PTS | PPG Paints Arena · Pittsburgh, PA |
| 25 | Mon Dec 4 | vsPenguins | W2-1 (OT) | 13-10-2 | 28 PTS | Wells Fargo Center · Philadelphia, PA |
| 26 | Thu Dec 7 | atCoyotes | W4-1 | 14-10-2 | 30 PTS | Mullett Arena · Tempe, AZ |
| 27 | Sat Dec 9 | atAvalanche | W5-2 | 15-10-2 | 32 PTS | Ball Arena · Denver, CO |
| 28 | Tue Dec 12 | atPredators | L2-3 (OT) | 15-10-3 | 33 PTS | Bridgestone Arena · Nashville, TN |
| 29 | Thu Dec 14 | vsCapitals | W4-3 (SO) | 16-10-3 | 35 PTS | Wells Fargo Center · Philadelphia, PA |
| 30 | Sat Dec 16 | vsRed Wings | W1-0 | 17-10-3 | 37 PTS | Wells Fargo Center · Philadelphia, PA |
| 31 | Tue Dec 19 | atDevils | W3-2 (OT) | 18-10-3 | 39 PTS | Prudential Center · Newark, NJ |
| 32 | Thu Dec 21 | vsPredators | L2-4 | 18-11-3 | 39 PTS | Wells Fargo Center · Philadelphia, PA |
| 33 | Fri Dec 22 | atRed Wings | L6-7 (SO) | 18-11-4 | 40 PTS | Little Caesars Arena · Detroit, MI |
| 34 | Thu Dec 28 | atCanucks | W4-1 | 19-11-4 | 42 PTS | Rogers Arena · Vancouver, British Columbia |
| 35 | Fri Dec 29 | atKraken | L1-2 (OT) | 19-11-5 | 43 PTS | Climate Pledge Arena · Seattle, WA |
| 36 | Sun Dec 31 | atFlames | L3-4 | 19-12-5 | 43 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 37 | Tue Jan 2 | atOilers | L2-5 | 19-13-5 | 43 PTS | Rogers Place · Edmonton, AB |
| 38 | Thu Jan 4 | vsJackets | L2-3 (SO) | 19-13-6 | 44 PTS | Wells Fargo Center · Philadelphia, PA |
| 39 | Sat Jan 6 | vsFlames | W3-2 | 20-13-6 | 46 PTS | Wells Fargo Center · Philadelphia, PA |
| 40 | Mon Jan 8 | vsPenguins | L1-4 | 20-14-6 | 46 PTS | Wells Fargo Center · Philadelphia, PA |
| 41 | Wed Jan 10 | vsCanadiens | W3-2 (SO) | 21-14-6 | 48 PTS | Wells Fargo Center · Philadelphia, PA |
| 42 | Fri Jan 12 | atWild | W4-3 (OT) | 22-14-6 | 50 PTS | Xcel Energy Center · St. Paul, MN |
| 43 | Sat Jan 13 | atJets | W2-0 | 23-14-6 | 52 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 44 | Mon Jan 15 | atBlues | W4-2 | 24-14-6 | 54 PTS | Enterprise Center · St. Louis, MO |
| 45 | Thu Jan 18 | vsStars | W5-1 | 25-14-6 | 56 PTS | Wells Fargo Center · Philadelphia, PA |
| 46 | Sat Jan 20 | vsAvalanche | L4-7 | 25-15-6 | 56 PTS | Wells Fargo Center · Philadelphia, PA |
| 47 | Sun Jan 21 | vsSenators | L3-5 | 25-16-6 | 56 PTS | Wells Fargo Center · Philadelphia, PA |
| 48 | Tue Jan 23 | vsLightning | L3-6 | 25-17-6 | 56 PTS | Wells Fargo Center · Philadelphia, PA |
| 49 | Thu Jan 25 | atRed Wings | L0-3 | 25-18-6 | 56 PTS | Little Caesars Arena · Detroit, MI |
| 50 | Sat Jan 27 | vsBruins | L2-6 | 25-19-6 | 56 PTS | Wells Fargo Center · Philadelphia, PA |
| 51 | Tue Feb 6 | atPanthers | W2-1 | 26-19-6 | 58 PTS | Amerant Bank Arena · Sunrise, FL |
| 52 | Thu Feb 8 | vsJets | W4-1 | 27-19-6 | 60 PTS | Wells Fargo Center · Philadelphia, PA |
| 53 | Sat Feb 10 | vsKraken | W3-2 | 28-19-6 | 62 PTS | Wells Fargo Center · Philadelphia, PA |
| 54 | Mon Feb 12 | vsCoyotes | W5-3 | 29-19-6 | 64 PTS | Wells Fargo Center · Philadelphia, PA |
| 55 | Thu Feb 15 | atMaple Leafs | L3-4 (OT) | 29-19-7 | 65 PTS | Scotiabank Arena · Toronto, ON |
| 56 | Sat Feb 17 | atDevils | L3-6 | 29-20-7 | 65 PTS | Prudential Center · Newark, NJ |
| 57 | Wed Feb 21 | atBlackhawks | W3-1 | 30-20-7 | 67 PTS | United Center · Chicago, IL |
| 58 | Sat Feb 24 | vsRangers | L1-2 | 30-21-7 | 67 PTS | Wells Fargo Center · Philadelphia, PA |
| 59 | Sun Feb 25 | atPenguins | L6-7 | 30-22-7 | 67 PTS | PPG Paints Arena · Pittsburgh, PA |
| 60 | Tue Feb 27 | vsLightning | W6-2 | 31-22-7 | 69 PTS | Wells Fargo Center · Philadelphia, PA |
| 61 | Fri Mar 1 | atCapitals | L2-5 | 31-23-7 | 69 PTS | Capital One Arena · Washington, D.C. |
| 62 | Sat Mar 2 | vsSenators | W4-2 | 32-23-7 | 71 PTS | Wells Fargo Center · Philadelphia, PA |
| 63 | Mon Mar 4 | vsBlues | L1-2 (SO) | 32-23-8 | 72 PTS | Wells Fargo Center · Philadelphia, PA |
| 64 | Thu Mar 7 | atPanthers | W2-1 | 33-23-8 | 74 PTS | Amerant Bank Arena · Sunrise, FL |
| 65 | Sat Mar 9 | atLightning | L0-7 | 33-24-8 | 74 PTS | AMALIE Arena · Tampa, FL |
| 66 | Tue Mar 12 | vsSharks | W3-2 | 34-24-8 | 76 PTS | Wells Fargo Center · Philadelphia, PA |
| 67 | Thu Mar 14 | vsMaple Leafs | L2-6 | 34-25-8 | 76 PTS | Wells Fargo Center · Philadelphia, PA |
| 68 | Sat Mar 16 | atBruins | L5-6 | 34-26-8 | 76 PTS | TD Garden · Boston, MA |
| 69 | Tue Mar 19 | vsMaple Leafs | W4-3 | 35-26-8 | 78 PTS | Wells Fargo Center · Philadelphia, PA |
| 70 | Thu Mar 21 | atHurricanes | L2-3 (OT) | 35-26-9 | 79 PTS | PNC Arena · Raleigh, NC |
| 71 | Sat Mar 23 | vsBruins | W3-2 | 36-26-9 | 81 PTS | Wells Fargo Center · Philadelphia, PA |
| 72 | Sun Mar 24 | vsPanthers | L1-4 | 36-27-9 | 81 PTS | Wells Fargo Center · Philadelphia, PA |
| 73 | Tue Mar 26 | atRangers | L5-6 (OT) | 36-27-10 | 82 PTS | Madison Square Garden · Manhattan, NY |
| 74 | Thu Mar 28 | atCanadiens | L1-4 | 36-28-10 | 82 PTS | Bell Centre · Montreal, QC |
| 75 | Sat Mar 30 | vsBlackhawks | L1-5 | 36-29-10 | 82 PTS | Wells Fargo Center · Philadelphia, PA |
| 76 | Mon Apr 1 | vsIslanders | L3-4 (OT) | 36-29-11 | 83 PTS | Wells Fargo Center · Philadelphia, PA |
| 77 | Fri Apr 5 | atSabres | L2-4 | 36-30-11 | 83 PTS | KeyBank Center · Buffalo, NY |
| 78 | Sat Apr 6 | atJackets | L2-6 | 36-31-11 | 83 PTS | Nationwide Arena · Columbus, OH |
| 79 | Tue Apr 9 | atCanadiens | L3-9 | 36-32-11 | 83 PTS | Bell Centre · Montreal, QC |
| 80 | Thu Apr 11 | atRangers | W4-1 | 37-32-11 | 85 PTS | Madison Square Garden · Manhattan, NY |
| 81 | Sat Apr 13 | vsDevils | W1-0 | 38-32-11 | 87 PTS | Wells Fargo Center · Philadelphia, PA |
| 82 | Tue Apr 16 | vsCapitals | L1-2 | 38-33-11 | 87 PTS | Wells Fargo Center · Philadelphia, PA |
