| 1 | Wed Oct 13 | vs Canadiens | W2-1 | 1-0-0 | 2 PTS | Scotiabank Arena · Toronto, ON |
| 2 | Thu Oct 14 | atSenators | L2-3 | 1-1-0 | 2 PTS | Canadian Tire Centre · Ottawa, ON |
| 3 | Sat Oct 16 | vsSenators | W3-1 | 2-1-0 | 4 PTS | Scotiabank Arena · Toronto, ON |
| 4 | Mon Oct 18 | vsRangers | L1-2 (OT) | 2-1-1 | 5 PTS | Scotiabank Arena · Toronto, ON |
| 5 | Fri Oct 22 | vsSharks | L3-5 | 2-2-1 | 5 PTS | Scotiabank Arena · Toronto, ON |
| 6 | Sat Oct 23 | atPenguins | L1-7 | 2-3-1 | 5 PTS | PPG Paints Arena · Pittsburgh, PA |
| 7 | Mon Oct 25 | atHurricanes | L1-4 | 2-4-1 | 5 PTS | PNC Arena · Raleigh, NC |
| 8 | Wed Oct 27 | atBlackhawks | W3-2 (OT) | 3-4-1 | 7 PTS | United Center · Chicago, IL |
| 9 | Sat Oct 30 | vsRed Wings | W5-4 | 4-4-1 | 9 PTS | Scotiabank Arena · Toronto, ON |
| 10 | Tue Nov 2 | vsKnights | W4-0 | 5-4-1 | 11 PTS | Scotiabank Arena · Toronto, ON |
| 11 | Thu Nov 4 | vsLightning | W2-1 (OT) | 6-4-1 | 13 PTS | Scotiabank Arena · Toronto, ON |
| 12 | Sat Nov 6 | vsBruins | W5-2 | 7-4-1 | 15 PTS | Scotiabank Arena · Toronto, ON |
| 13 | Mon Nov 8 | vsKings | L1-5 | 7-5-1 | 15 PTS | Scotiabank Arena · Toronto, ON |
| 14 | Wed Nov 10 | atFlyers | W3-0 | 8-5-1 | 17 PTS | Wells Fargo Center · Philadelphia, PA |
| 15 | Fri Nov 12 | vsFlames | W2-1 (OT) | 9-5-1 | 19 PTS | Scotiabank Arena · Toronto, ON |
| 16 | Sat Nov 13 | atSabres | W5-4 | 10-5-1 | 21 PTS | KeyBank Center · Buffalo, NY |
| 17 | Tue Nov 16 | vsPredators | W3-0 | 11-5-1 | 23 PTS | Scotiabank Arena · Toronto, ON |
| 18 | Thu Nov 18 | vsRangers | W2-1 | 12-5-1 | 25 PTS | Scotiabank Arena · Toronto, ON |
| 19 | Sat Nov 20 | vsPenguins | L0-2 | 12-6-1 | 25 PTS | Scotiabank Arena · Toronto, ON |
| 20 | Sun Nov 21 | atIslanders | W3-0 | 13-6-1 | 27 PTS | UBS Arena · Elmont, NY |
| 21 | Wed Nov 24 | atKings | W6-2 | 14-6-1 | 29 PTS | Crypto.com Arena · Los Angeles, CA |
| 22 | Fri Nov 26 | atSharks | W4-1 | 15-6-1 | 31 PTS | SAP Center · San Jose, CA |
| 23 | Sun Nov 28 | atDucks | W5-1 | 16-6-1 | 33 PTS | Honda Center · Anaheim, CA |
| 24 | Wed Dec 1 | vsAvalanche | W8-3 | 17-6-1 | 35 PTS | Scotiabank Arena · Toronto, ON |
| 25 | Sat Dec 4 | atWild | L3-4 (SO) | 17-6-2 | 36 PTS | Xcel Energy Center · St. Paul, MN |
| 26 | Sun Dec 5 | atJets | L3-6 | 17-7-2 | 36 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 27 | Tue Dec 7 | vsJackets | W5-4 | 18-7-2 | 38 PTS | Scotiabank Arena · Toronto, ON |
| 28 | Thu Dec 9 | vsLightning | L3-5 | 18-8-2 | 38 PTS | Scotiabank Arena · Toronto, ON |
| 29 | Sat Dec 11 | vsBlackhawks | W5-4 | 19-8-2 | 40 PTS | Scotiabank Arena · Toronto, ON |
| 30 | Tue Dec 14 | atOilers | W5-1 | 20-8-2 | 42 PTS | Rogers Place · Edmonton, AB |
| 31 | Sat Jan 1 | vsSenators | W6-0 | 21-8-2 | 44 PTS | Scotiabank Arena · Toronto, ON |
| 32 | Wed Jan 5 | vsOilers | W4-2 | 22-8-2 | 46 PTS | Scotiabank Arena · Toronto, ON |
| 33 | Sat Jan 8 | atAvalanche | L4-5 (OT) | 22-8-3 | 47 PTS | Ball Arena · Denver, CO |
| 34 | Tue Jan 11 | atKnights | W4-3 (SO) | 23-8-3 | 49 PTS | T-Mobile Arena · Las Vegas, NV |
| 35 | Wed Jan 12 | atCoyotes | L1-2 | 23-9-3 | 49 PTS | Mullett Arena · Tempe, AZ |
| 36 | Sat Jan 15 | atBlues | W6-5 | 24-9-3 | 51 PTS | Enterprise Center · St. Louis, MO |
| 37 | Wed Jan 19 | atRangers | L3-6 | 24-10-3 | 51 PTS | Madison Square Garden · Manhattan, NY |
| 38 | Sat Jan 22 | atIslanders | W3-1 | 25-10-3 | 53 PTS | UBS Arena · Elmont, NY |
| 39 | Wed Jan 26 | vsDucks | W4-3 (SO) | 26-10-3 | 55 PTS | Scotiabank Arena · Toronto, ON |
| 40 | Sat Jan 29 | atRed Wings | W7-4 | 27-10-3 | 57 PTS | Little Caesars Arena · Detroit, MI |
| 41 | Mon Jan 31 | vsDevils | W6-4 | 28-10-3 | 59 PTS | Scotiabank Arena · Toronto, ON |
| 42 | Tue Feb 1 | atDevils | W7-1 | 29-10-3 | 61 PTS | Prudential Center · Newark, NJ |
| 43 | Mon Feb 7 | vsHurricanes | W4-3 (OT) | 30-10-3 | 63 PTS | Scotiabank Arena · Toronto, ON |
| 44 | Thu Feb 10 | atFlames | L2-5 | 30-11-3 | 63 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 45 | Sat Feb 12 | atCanucks | L2-3 | 30-12-3 | 63 PTS | Rogers Arena · Vancouver, British Columbia |
| 46 | Mon Feb 14 | atKraken | W6-2 | 31-12-3 | 65 PTS | Climate Pledge Arena · Seattle, WA |
| 47 | Thu Feb 17 | vsPenguins | W4-1 | 32-12-3 | 67 PTS | Scotiabank Arena · Toronto, ON |
| 48 | Sat Feb 19 | vsBlues | L3-6 | 32-13-3 | 67 PTS | Scotiabank Arena · Toronto, ON |
| 49 | Mon Feb 21 | atCanadiens | L2-5 | 32-14-3 | 67 PTS | Bell Centre · Montreal, QC |
| 50 | Tue Feb 22 | atJackets | L3-4 (OT) | 32-14-4 | 68 PTS | Nationwide Arena · Columbus, OH |
| 51 | Thu Feb 24 | vsWild | W3-1 | 33-14-4 | 70 PTS | Scotiabank Arena · Toronto, ON |
| 52 | Sat Feb 26 | atRed Wings | W10-7 | 34-14-4 | 72 PTS | Little Caesars Arena · Detroit, MI |
| 53 | Mon Feb 28 | atCapitals | W5-3 | 35-14-4 | 74 PTS | Capital One Arena · Washington, D.C. |
| 54 | Wed Mar 2 | vsSabres | L1-5 | 35-15-4 | 74 PTS | Scotiabank Arena · Toronto, ON |
| 55 | Sat Mar 5 | vsCanucks | L4-6 | 35-16-4 | 74 PTS | Scotiabank Arena · Toronto, ON |
| 56 | Mon Mar 7 | atJackets | W5-4 | 36-16-4 | 76 PTS | Nationwide Arena · Columbus, OH |
| 57 | Tue Mar 8 | vsKraken | W6-4 | 37-16-4 | 78 PTS | Scotiabank Arena · Toronto, ON |
| 58 | Thu Mar 10 | vsCoyotes | L4-5 (OT) | 37-16-5 | 79 PTS | Scotiabank Arena · Toronto, ON |
| 59 | Sun Mar 13 | atSabres | L2-5 | 37-17-5 | 79 PTS | KeyBank Center · Buffalo, NY |
| 60 | Tue Mar 15 | vsStars | W4-0 | 38-17-5 | 81 PTS | Scotiabank Arena · Toronto, ON |
| 61 | Thu Mar 17 | vsHurricanes | W3-2 | 39-17-5 | 83 PTS | Scotiabank Arena · Toronto, ON |
| 62 | Sat Mar 19 | atPredators | L3-6 | 39-18-5 | 83 PTS | Bridgestone Arena · Nashville, TN |
| 63 | Wed Mar 23 | vsDevils | W3-2 | 40-18-5 | 85 PTS | Scotiabank Arena · Toronto, ON |
| 64 | Sat Mar 26 | atCanadiens | L2-4 | 40-19-5 | 85 PTS | Bell Centre · Montreal, QC |
| 65 | Sun Mar 27 | vsPanthers | W5-2 | 41-19-5 | 87 PTS | Scotiabank Arena · Toronto, ON |
| 66 | Tue Mar 29 | atBruins | W6-4 | 42-19-5 | 89 PTS | TD Garden · Boston, MA |
| 67 | Thu Mar 31 | vsJets | W7-3 | 43-19-5 | 91 PTS | Scotiabank Arena · Toronto, ON |
| 68 | Sat Apr 2 | atFlyers | W6-3 | 44-19-5 | 93 PTS | Wells Fargo Center · Philadelphia, PA |
| 69 | Mon Apr 4 | atLightning | W6-2 | 45-19-5 | 95 PTS | AMALIE Arena · Tampa, FL |
| 70 | Tue Apr 5 | atPanthers | L6-7 (OT) | 45-19-6 | 96 PTS | Amerant Bank Arena · Sunrise, FL |
| 71 | Thu Apr 7 | atStars | W4-3 (OT) | 46-19-6 | 98 PTS | American Airlines Center · Dallas, TX |
| 72 | Sat Apr 9 | vsCanadiens | W3-2 | 47-19-6 | 100 PTS | Scotiabank Arena · Toronto, ON |
| 73 | Tue Apr 12 | vsSabres | L2-5 | 47-20-6 | 100 PTS | Scotiabank Arena · Toronto, ON |
| 74 | Thu Apr 14 | vsCapitals | W7-3 | 48-20-6 | 102 PTS | Scotiabank Arena · Toronto, ON |
| 75 | Sat Apr 16 | atSenators | W5-4 (OT) | 49-20-6 | 104 PTS | Canadian Tire Centre · Ottawa, ON |
| 76 | Sun Apr 17 | vsIslanders | W4-2 | 50-20-6 | 106 PTS | Scotiabank Arena · Toronto, ON |
| 77 | Tue Apr 19 | vsFlyers | W5-2 | 51-20-6 | 108 PTS | Scotiabank Arena · Toronto, ON |
| 78 | Thu Apr 21 | atLightning | L1-8 | 51-21-6 | 108 PTS | AMALIE Arena · Tampa, FL |
| 79 | Sat Apr 23 | atPanthers | L2-3 (OT) | 51-21-7 | 109 PTS | Amerant Bank Arena · Sunrise, FL |
| 80 | Sun Apr 24 | atCapitals | W4-3 (SO) | 52-21-7 | 111 PTS | Capital One Arena · Washington, D.C. |
| 81 | Tue Apr 26 | vsRed Wings | W3-0 | 53-21-7 | 113 PTS | Scotiabank Arena · Toronto, ON |
| 82 | Fri Apr 29 | vsBruins | W5-2 | 54-21-7 | 115 PTS | Scotiabank Arena · Toronto, ON |
| 1 | Mon May 2 | vsLightning | W5-0 | 1-0 | 1.000 | Scotiabank Arena · Toronto, ON |
| 2 | Wed May 4 | vsLightning | L3-5 | 1-1 | .500 | Scotiabank Arena · Toronto, ON |
| 3 | Fri May 6 | atLightning | W5-2 | 2-1 | .667 | AMALIE Arena · Tampa, FL |
| 4 | Sun May 8 | atLightning | L3-7 | 2-2 | .500 | AMALIE Arena · Tampa, FL |
| 5 | Tue May 10 | vsLightning | W4-3 | 3-2 | .600 | Scotiabank Arena · Toronto, ON |
| 6 | Thu May 12 | atLightning | L3-4 (OT) | 3-3 | .500 | AMALIE Arena · Tampa, FL |
| 7 | Sat May 14 | vsLightning | L1-2 | 3-4 | .429 | Scotiabank Arena · Toronto, ON |
