| 1 | Wed Oct 11 | vs Canadiens | W6-5 (SO) | 1-0-0 | 2 PTS | Scotiabank Arena · Toronto, ON |
| 2 | Sat Oct 14 | vsWild | W7-4 | 2-0-0 | 4 PTS | Scotiabank Arena · Toronto, ON |
| 3 | Mon Oct 16 | vsBlackhawks | L1-4 | 2-1-0 | 4 PTS | Scotiabank Arena · Toronto, ON |
| 4 | Thu Oct 19 | atPanthers | L1-3 | 2-2-0 | 4 PTS | Amerant Bank Arena · Sunrise, FL |
| 5 | Sat Oct 21 | atLightning | W4-3 (OT) | 3-2-0 | 6 PTS | AMALIE Arena · Tampa, FL |
| 6 | Tue Oct 24 | atCapitals | W4-1 | 4-2-0 | 8 PTS | Capital One Arena · Washington, D.C. |
| 7 | Thu Oct 26 | atStars | W4-1 | 5-2-0 | 10 PTS | American Airlines Center · Dallas, TX |
| 8 | Sat Oct 28 | atPredators | L2-3 (OT) | 5-2-1 | 11 PTS | Bridgestone Arena · Nashville, TN |
| 9 | Tue Oct 31 | vsKings | L1-4 | 5-3-1 | 11 PTS | Scotiabank Arena · Toronto, ON |
| 10 | Thu Nov 2 | atBruins | L2-3 (SO) | 5-3-2 | 12 PTS | TD Garden · Boston, MA |
| 11 | Sat Nov 4 | vsSabres | L4-6 | 5-4-2 | 12 PTS | Scotiabank Arena · Toronto, ON |
| 12 | Mon Nov 6 | vsLightning | W6-5 (OT) | 6-4-2 | 14 PTS | Scotiabank Arena · Toronto, ON |
| 13 | Wed Nov 8 | vsSenators | L3-6 | 6-5-2 | 14 PTS | Scotiabank Arena · Toronto, ON |
| 14 | Fri Nov 10 | vsFlames | W5-4 (SO) | 7-5-2 | 16 PTS | Scotiabank Arena · Toronto, ON |
| 15 | Sat Nov 11 | vsCanucks | W5-2 | 8-5-2 | 18 PTS | Scotiabank Arena · Toronto, ON |
| 16 | Fri Nov 17 | atRed Wings | W3-2 | 9-5-2 | 20 PTS | Little Caesars Arena · Detroit, MI |
| 17 | Sun Nov 19 | atWild | W4-3 (OT) | 10-5-2 | 22 PTS | Xcel Energy Center · St. Paul, MN |
| 18 | Fri Nov 24 | atBlackhawks | L3-4 (OT) | 10-5-3 | 23 PTS | United Center · Chicago, IL |
| 19 | Sat Nov 25 | atPenguins | L2-3 | 10-6-3 | 23 PTS | PPG Paints Arena · Pittsburgh, PA |
| 20 | Tue Nov 28 | vsPanthers | W2-1 (SO) | 11-6-3 | 25 PTS | Scotiabank Arena · Toronto, ON |
| 21 | Thu Nov 30 | vsKraken | W4-3 (SO) | 12-6-3 | 27 PTS | Scotiabank Arena · Toronto, ON |
| 22 | Sat Dec 2 | vsBruins | L3-4 (OT) | 12-6-4 | 28 PTS | Scotiabank Arena · Toronto, ON |
| 23 | Thu Dec 7 | atSenators | W4-3 | 13-6-4 | 30 PTS | Canadian Tire Centre · Ottawa, ON |
| 24 | Sat Dec 9 | vsPredators | W4-0 | 14-6-4 | 32 PTS | Scotiabank Arena · Toronto, ON |
| 25 | Mon Dec 11 | atIslanders | L3-4 (OT) | 14-6-5 | 33 PTS | UBS Arena · Elmont, NY |
| 26 | Tue Dec 12 | atRangers | W7-3 | 15-6-5 | 35 PTS | Madison Square Garden · Manhattan, NY |
| 27 | Thu Dec 14 | vsJackets | L5-6 (OT) | 15-6-6 | 36 PTS | Scotiabank Arena · Toronto, ON |
| 28 | Sat Dec 16 | vsPenguins | W7-0 | 16-6-6 | 38 PTS | Scotiabank Arena · Toronto, ON |
| 29 | Tue Dec 19 | vsRangers | L2-5 | 16-7-6 | 38 PTS | Scotiabank Arena · Toronto, ON |
| 30 | Thu Dec 21 | atSabres | L3-9 | 16-8-6 | 38 PTS | KeyBank Center · Buffalo, NY |
| 31 | Sat Dec 23 | atJackets | W4-1 | 17-8-6 | 40 PTS | Nationwide Arena · Columbus, OH |
| 32 | Wed Dec 27 | vsSenators | L2-4 | 17-9-6 | 40 PTS | Scotiabank Arena · Toronto, ON |
| 33 | Fri Dec 29 | atJackets | L5-6 (OT) | 17-9-7 | 41 PTS | Nationwide Arena · Columbus, OH |
| 34 | Sat Dec 30 | vsHurricanes | L2-3 | 17-10-7 | 41 PTS | Scotiabank Arena · Toronto, ON |
| 35 | Tue Jan 2 | atKings | W3-0 | 18-10-7 | 43 PTS | Crypto.com Arena · Los Angeles, CA |
| 36 | Wed Jan 3 | atDucks | W2-1 (OT) | 19-10-7 | 45 PTS | Honda Center · Anaheim, CA |
| 37 | Sat Jan 6 | atSharks | W4-1 | 20-10-7 | 47 PTS | SAP Center · San Jose, CA |
| 38 | Tue Jan 9 | vsSharks | W7-1 | 21-10-7 | 49 PTS | Scotiabank Arena · Toronto, ON |
| 39 | Thu Jan 11 | atIslanders | L3-4 (OT) | 21-10-8 | 50 PTS | UBS Arena · Elmont, NY |
| 40 | Sat Jan 13 | vsAvalanche | L3-5 | 21-11-8 | 50 PTS | Scotiabank Arena · Toronto, ON |
| 41 | Sun Jan 14 | vsRed Wings | L2-4 | 21-12-8 | 50 PTS | Scotiabank Arena · Toronto, ON |
| 42 | Tue Jan 16 | atOilers | L2-4 | 21-13-8 | 50 PTS | Rogers Place · Edmonton, AB |
| 43 | Thu Jan 18 | atFlames | W4-3 | 22-13-8 | 52 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 44 | Sat Jan 20 | atCanucks | L4-6 | 22-14-8 | 52 PTS | Rogers Arena · Vancouver, British Columbia |
| 45 | Sun Jan 21 | atKraken | W3-1 | 23-14-8 | 54 PTS | Climate Pledge Arena · Seattle, WA |
| 46 | Wed Jan 24 | vsJets | W1-0 (OT) | 24-14-8 | 56 PTS | Scotiabank Arena · Toronto, ON |
| 47 | Sat Jan 27 | atJets | W4-2 | 25-14-8 | 58 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 48 | Mon Feb 5 | vsIslanders | L2-3 | 25-15-8 | 58 PTS | Scotiabank Arena · Toronto, ON |
| 49 | Wed Feb 7 | vsStars | W5-4 | 26-15-8 | 60 PTS | Scotiabank Arena · Toronto, ON |
| 50 | Sat Feb 10 | atSenators | L3-5 | 26-16-8 | 60 PTS | Canadian Tire Centre · Ottawa, ON |
| 51 | Tue Feb 13 | vsBlues | W4-1 | 27-16-8 | 62 PTS | Scotiabank Arena · Toronto, ON |
| 52 | Thu Feb 15 | vsFlyers | W4-3 (OT) | 28-16-8 | 64 PTS | Scotiabank Arena · Toronto, ON |
| 53 | Sat Feb 17 | vsDucks | W9-2 | 29-16-8 | 66 PTS | Scotiabank Arena · Toronto, ON |
| 54 | Mon Feb 19 | atBlues | W4-2 | 30-16-8 | 68 PTS | Enterprise Center · St. Louis, MO |
| 55 | Wed Feb 21 | atCoyotes | W6-3 | 31-16-8 | 70 PTS | Mullett Arena · Tempe, AZ |
| 56 | Thu Feb 22 | atKnights | W7-3 | 32-16-8 | 72 PTS | T-Mobile Arena · Las Vegas, NV |
| 57 | Sat Feb 24 | atAvalanche | W4-3 | 33-16-8 | 74 PTS | Ball Arena · Denver, CO |
| 58 | Tue Feb 27 | vsKnights | L2-6 | 33-17-8 | 74 PTS | Scotiabank Arena · Toronto, ON |
| 59 | Thu Feb 29 | vsCoyotes | W4-2 | 34-17-8 | 76 PTS | Scotiabank Arena · Toronto, ON |
| 60 | Sat Mar 2 | vsRangers | W4-3 (SO) | 35-17-8 | 78 PTS | Scotiabank Arena · Toronto, ON |
| 61 | Mon Mar 4 | vsBruins | L1-4 | 35-18-8 | 78 PTS | Scotiabank Arena · Toronto, ON |
| 62 | Wed Mar 6 | vsSabres | W2-1 (OT) | 36-18-8 | 80 PTS | Scotiabank Arena · Toronto, ON |
| 63 | Thu Mar 7 | atBruins | L1-4 | 36-19-8 | 80 PTS | TD Garden · Boston, MA |
| 64 | Sat Mar 9 | atCanadiens | W3-2 | 37-19-8 | 82 PTS | Bell Centre · Montreal, QC |
| 65 | Thu Mar 14 | atFlyers | W6-2 | 38-19-8 | 84 PTS | Wells Fargo Center · Philadelphia, PA |
| 66 | Sat Mar 16 | vsHurricanes | L4-5 (SO) | 38-19-9 | 85 PTS | Scotiabank Arena · Toronto, ON |
| 67 | Tue Mar 19 | atFlyers | L3-4 | 38-20-9 | 85 PTS | Wells Fargo Center · Philadelphia, PA |
| 68 | Wed Mar 20 | atCapitals | W7-3 | 39-20-9 | 87 PTS | Capital One Arena · Washington, D.C. |
| 69 | Sat Mar 23 | vsOilers | W6-3 | 40-20-9 | 89 PTS | Scotiabank Arena · Toronto, ON |
| 70 | Sun Mar 24 | atHurricanes | L1-2 | 40-21-9 | 89 PTS | PNC Arena · Raleigh, NC |
| 71 | Tue Mar 26 | vsDevils | L3-6 | 40-22-9 | 89 PTS | Scotiabank Arena · Toronto, ON |
| 72 | Thu Mar 28 | vsCapitals | W5-1 | 41-22-9 | 91 PTS | Scotiabank Arena · Toronto, ON |
| 73 | Sat Mar 30 | atSabres | W3-0 | 42-22-9 | 93 PTS | KeyBank Center · Buffalo, NY |
| 74 | Mon Apr 1 | vsPanthers | W6-4 | 43-22-9 | 95 PTS | Scotiabank Arena · Toronto, ON |
| 75 | Wed Apr 3 | vsLightning | L1-4 | 43-23-9 | 95 PTS | Scotiabank Arena · Toronto, ON |
| 76 | Sat Apr 6 | atCanadiens | W4-2 | 44-23-9 | 97 PTS | Bell Centre · Montreal, QC |
| 77 | Mon Apr 8 | vsPenguins | W3-2 (OT) | 45-23-9 | 99 PTS | Scotiabank Arena · Toronto, ON |
| 78 | Tue Apr 9 | atDevils | W5-2 | 46-23-9 | 101 PTS | Prudential Center · Newark, NJ |
| 79 | Thu Apr 11 | vsDevils | L5-6 | 46-24-9 | 101 PTS | Scotiabank Arena · Toronto, ON |
| 80 | Sat Apr 13 | vsRed Wings | L4-5 (OT) | 46-24-10 | 102 PTS | Scotiabank Arena · Toronto, ON |
| 81 | Tue Apr 16 | atPanthers | L2-5 | 46-25-10 | 102 PTS | Amerant Bank Arena · Sunrise, FL |
| 82 | Wed Apr 17 | atLightning | L4-6 | 46-26-10 | 102 PTS | AMALIE Arena · Tampa, FL |
| 1 | Sat Apr 20 | atBruins | L1-5 | 0-1 | .000 | TD Garden · Boston, MA |
| 2 | Mon Apr 22 | atBruins | W3-2 | 1-1 | .500 | TD Garden · Boston, MA |
| 3 | Wed Apr 24 | vsBruins | L2-4 | 1-2 | .333 | Scotiabank Arena · Toronto, ON |
| 4 | Sat Apr 27 | vsBruins | L1-3 | 1-3 | .250 | Scotiabank Arena · Toronto, ON |
| 5 | Tue Apr 30 | atBruins | W2-1 (OT) | 2-3 | .400 | TD Garden · Boston, MA |
| 6 | Thu May 2 | vsBruins | W2-1 | 3-3 | .500 | Scotiabank Arena · Toronto, ON |
| 7 | Sat May 4 | atBruins | L1-2 (OT) | 3-4 | .429 | TD Garden · Boston, MA |
