| 1 | Wed Oct 12 | at Canadiens | L3-4 | 0-1-0 | 0 PTS | Bell Centre · Montreal, QC |
| 2 | Thu Oct 13 | vsCapitals | W3-2 | 1-1-0 | 2 PTS | Scotiabank Arena · Toronto, ON |
| 3 | Sat Oct 15 | vsSenators | W3-2 | 2-1-0 | 4 PTS | Scotiabank Arena · Toronto, ON |
| 4 | Mon Oct 17 | vsCoyotes | L2-4 | 2-2-0 | 4 PTS | Scotiabank Arena · Toronto, ON |
| 5 | Thu Oct 20 | vsStars | W3-2 (OT) | 3-2-0 | 6 PTS | Scotiabank Arena · Toronto, ON |
| 6 | Sat Oct 22 | atJets | W4-1 | 4-2-0 | 8 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 7 | Mon Oct 24 | atKnights | L1-3 | 4-3-0 | 8 PTS | T-Mobile Arena · Las Vegas, NV |
| 8 | Thu Oct 27 | atSharks | L3-4 (OT) | 4-3-1 | 9 PTS | SAP Center · San Jose, CA |
| 9 | Sat Oct 29 | atKings | L2-4 | 4-4-1 | 9 PTS | Crypto.com Arena · Los Angeles, CA |
| 10 | Sun Oct 30 | atDucks | L3-4 (OT) | 4-4-2 | 10 PTS | Honda Center · Anaheim, CA |
| 11 | Wed Nov 2 | vsFlyers | W5-2 | 5-4-2 | 12 PTS | Scotiabank Arena · Toronto, ON |
| 12 | Sat Nov 5 | vsBruins | W2-1 | 6-4-2 | 14 PTS | Scotiabank Arena · Toronto, ON |
| 13 | Sun Nov 6 | atHurricanes | W3-1 | 7-4-2 | 16 PTS | PNC Arena · Raleigh, NC |
| 14 | Tue Nov 8 | vsKnights | L3-4 (OT) | 7-4-3 | 17 PTS | Scotiabank Arena · Toronto, ON |
| 15 | Fri Nov 11 | vsPenguins | L2-4 | 7-5-3 | 17 PTS | Scotiabank Arena · Toronto, ON |
| 16 | Sat Nov 12 | vsCanucks | W3-2 | 8-5-3 | 19 PTS | Scotiabank Arena · Toronto, ON |
| 17 | Tue Nov 15 | atPenguins | W5-2 | 9-5-3 | 21 PTS | PPG Paints Arena · Pittsburgh, PA |
| 18 | Thu Nov 17 | vsDevils | L2-3 (OT) | 9-5-4 | 22 PTS | Scotiabank Arena · Toronto, ON |
| 19 | Sat Nov 19 | vsSabres | W5-2 | 10-5-4 | 24 PTS | Scotiabank Arena · Toronto, ON |
| 20 | Mon Nov 21 | vsIslanders | L2-3 (OT) | 10-5-5 | 25 PTS | Scotiabank Arena · Toronto, ON |
| 21 | Wed Nov 23 | atDevils | W2-1 | 11-5-5 | 27 PTS | Prudential Center · Newark, NJ |
| 22 | Fri Nov 25 | atWild | W4-3 | 12-5-5 | 29 PTS | Xcel Energy Center · St. Paul, MN |
| 23 | Sat Nov 26 | atPenguins | W4-1 | 13-5-5 | 31 PTS | PPG Paints Arena · Pittsburgh, PA |
| 24 | Mon Nov 28 | atRed Wings | W4-2 | 14-5-5 | 33 PTS | Little Caesars Arena · Detroit, MI |
| 25 | Wed Nov 30 | vsSharks | W3-1 | 15-5-5 | 35 PTS | Scotiabank Arena · Toronto, ON |
| 26 | Sat Dec 3 | atLightning | L3-4 (OT) | 15-5-6 | 36 PTS | AMALIE Arena · Tampa, FL |
| 27 | Tue Dec 6 | atStars | W4-0 | 16-5-6 | 38 PTS | American Airlines Center · Dallas, TX |
| 28 | Thu Dec 8 | vsKings | W5-0 | 17-5-6 | 40 PTS | Scotiabank Arena · Toronto, ON |
| 29 | Sat Dec 10 | vsFlames | W5-4 (OT) | 18-5-6 | 42 PTS | Scotiabank Arena · Toronto, ON |
| 30 | Tue Dec 13 | vsDucks | W7-0 | 19-5-6 | 44 PTS | Scotiabank Arena · Toronto, ON |
| 31 | Thu Dec 15 | atRangers | L1-3 | 19-6-6 | 44 PTS | Madison Square Garden · Manhattan, NY |
| 32 | Sat Dec 17 | atCapitals | L2-5 | 19-7-6 | 44 PTS | Capital One Arena · Washington, D.C. |
| 33 | Tue Dec 20 | vsLightning | W4-1 | 20-7-6 | 46 PTS | Scotiabank Arena · Toronto, ON |
| 34 | Thu Dec 22 | vsFlyers | W4-3 | 21-7-6 | 48 PTS | Scotiabank Arena · Toronto, ON |
| 35 | Tue Dec 27 | atBlues | W5-4 (OT) | 22-7-6 | 50 PTS | Enterprise Center · St. Louis, MO |
| 36 | Thu Dec 29 | atCoyotes | L3-6 | 22-8-6 | 50 PTS | Mullett Arena · Tempe, AZ |
| 37 | Sat Dec 31 | atAvalanche | W6-2 | 23-8-6 | 52 PTS | Ball Arena · Denver, CO |
| 38 | Tue Jan 3 | vsBlues | L5-6 (SO) | 23-8-7 | 53 PTS | Scotiabank Arena · Toronto, ON |
| 39 | Thu Jan 5 | vsKraken | L1-5 | 23-9-7 | 53 PTS | Scotiabank Arena · Toronto, ON |
| 40 | Sat Jan 7 | vsRed Wings | W4-1 | 24-9-7 | 55 PTS | Scotiabank Arena · Toronto, ON |
| 41 | Sun Jan 8 | atFlyers | W6-2 | 25-9-7 | 57 PTS | Wells Fargo Center · Philadelphia, PA |
| 42 | Wed Jan 11 | vsPredators | W2-1 | 26-9-7 | 59 PTS | Scotiabank Arena · Toronto, ON |
| 43 | Thu Jan 12 | atRed Wings | L1-4 | 26-10-7 | 59 PTS | Little Caesars Arena · Detroit, MI |
| 44 | Sat Jan 14 | atBruins | L3-4 | 26-11-7 | 59 PTS | TD Garden · Boston, MA |
| 45 | Tue Jan 17 | vsPanthers | W5-4 (OT) | 27-11-7 | 61 PTS | Scotiabank Arena · Toronto, ON |
| 46 | Thu Jan 19 | vsJets | W4-1 | 28-11-7 | 63 PTS | Scotiabank Arena · Toronto, ON |
| 47 | Sat Jan 21 | atCanadiens | L2-3 (OT) | 28-11-8 | 64 PTS | Bell Centre · Montreal, QC |
| 48 | Mon Jan 23 | vsIslanders | W5-2 | 29-11-8 | 66 PTS | Scotiabank Arena · Toronto, ON |
| 49 | Wed Jan 25 | vsRangers | W3-2 (OT) | 30-11-8 | 68 PTS | Scotiabank Arena · Toronto, ON |
| 50 | Fri Jan 27 | vsSenators | L2-6 | 30-12-8 | 68 PTS | Scotiabank Arena · Toronto, ON |
| 51 | Sun Jan 29 | vsCapitals | W5-1 | 31-12-8 | 70 PTS | Scotiabank Arena · Toronto, ON |
| 52 | Wed Feb 1 | vsBruins | L2-5 | 31-13-8 | 70 PTS | Scotiabank Arena · Toronto, ON |
| 53 | Fri Feb 10 | atJackets | W3-0 | 32-13-8 | 72 PTS | Nationwide Arena · Columbus, OH |
| 54 | Sat Feb 11 | vsJackets | L3-4 | 32-14-8 | 72 PTS | Scotiabank Arena · Toronto, ON |
| 55 | Wed Feb 15 | vsBlackhawks | W5-2 | 33-14-8 | 74 PTS | Scotiabank Arena · Toronto, ON |
| 56 | Sat Feb 18 | vsCanadiens | W5-1 | 34-14-8 | 76 PTS | Scotiabank Arena · Toronto, ON |
| 57 | Sun Feb 19 | atBlackhawks | L3-5 | 34-15-8 | 76 PTS | United Center · Chicago, IL |
| 58 | Tue Feb 21 | atSabres | W6-3 | 35-15-8 | 78 PTS | KeyBank Center · Buffalo, NY |
| 59 | Fri Feb 24 | vsWild | W2-1 (OT) | 36-15-8 | 80 PTS | Scotiabank Arena · Toronto, ON |
| 60 | Sun Feb 26 | atKraken | W5-1 | 37-15-8 | 82 PTS | Climate Pledge Arena · Seattle, WA |
| 61 | Wed Mar 1 | atOilers | L2-5 | 37-16-8 | 82 PTS | Rogers Place · Edmonton, AB |
| 62 | Thu Mar 2 | atFlames | W2-1 | 38-16-8 | 84 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 63 | Sat Mar 4 | atCanucks | L1-4 | 38-17-8 | 84 PTS | Rogers Arena · Vancouver, British Columbia |
| 64 | Tue Mar 7 | atDevils | W4-3 | 39-17-8 | 86 PTS | Prudential Center · Newark, NJ |
| 65 | Sat Mar 11 | vsOilers | W7-4 | 40-17-8 | 88 PTS | Scotiabank Arena · Toronto, ON |
| 66 | Mon Mar 13 | vsSabres | L3-4 | 40-18-8 | 88 PTS | Scotiabank Arena · Toronto, ON |
| 67 | Wed Mar 15 | vsAvalanche | L1-2 (SO) | 40-18-9 | 89 PTS | Scotiabank Arena · Toronto, ON |
| 68 | Fri Mar 17 | vsHurricanes | W5-2 | 41-18-9 | 91 PTS | Scotiabank Arena · Toronto, ON |
| 69 | Sat Mar 18 | atSenators | W5-4 (SO) | 42-18-9 | 93 PTS | Canadian Tire Centre · Ottawa, ON |
| 70 | Tue Mar 21 | atIslanders | L2-7 | 42-19-9 | 93 PTS | UBS Arena · Elmont, NY |
| 71 | Thu Mar 23 | atPanthers | W6-2 | 43-19-9 | 95 PTS | Amerant Bank Arena · Sunrise, FL |
| 72 | Sat Mar 25 | atHurricanes | L3-5 | 43-20-9 | 95 PTS | PNC Arena · Raleigh, NC |
| 73 | Sun Mar 26 | atPredators | W3-2 | 44-20-9 | 97 PTS | Bridgestone Arena · Nashville, TN |
| 74 | Wed Mar 29 | vsPanthers | L2-3 (OT) | 44-20-10 | 98 PTS | Scotiabank Arena · Toronto, ON |
| 75 | Sat Apr 1 | atSenators | W3-0 | 45-20-10 | 100 PTS | Canadian Tire Centre · Ottawa, ON |
| 76 | Sun Apr 2 | vsRed Wings | L2-5 | 45-21-10 | 100 PTS | Scotiabank Arena · Toronto, ON |
| 77 | Tue Apr 4 | vsJackets | W4-2 | 46-21-10 | 102 PTS | Scotiabank Arena · Toronto, ON |
| 78 | Thu Apr 6 | atBruins | L1-2 (OT) | 46-21-11 | 103 PTS | TD Garden · Boston, MA |
| 79 | Sat Apr 8 | vsCanadiens | W7-1 | 47-21-11 | 105 PTS | Scotiabank Arena · Toronto, ON |
| 80 | Mon Apr 10 | atPanthers | W2-1 (OT) | 48-21-11 | 107 PTS | Amerant Bank Arena · Sunrise, FL |
| 81 | Tue Apr 11 | atLightning | W4-3 | 49-21-11 | 109 PTS | AMALIE Arena · Tampa, FL |
| 82 | Thu Apr 13 | atRangers | W3-2 | 50-21-11 | 111 PTS | Madison Square Garden · Manhattan, NY |
| 1 | Tue Apr 18 | vsLightning | L3-7 | 0-1 | .000 | Scotiabank Arena · Toronto, ON |
| 2 | Thu Apr 20 | vsLightning | W7-2 | 1-1 | .500 | Scotiabank Arena · Toronto, ON |
| 3 | Sat Apr 22 | atLightning | W4-3 (OT) | 2-1 | .667 | AMALIE Arena · Tampa, FL |
| 4 | Mon Apr 24 | atLightning | W5-4 (OT) | 3-1 | .750 | AMALIE Arena · Tampa, FL |
| 5 | Thu Apr 27 | vsLightning | L2-4 | 3-2 | .600 | Scotiabank Arena · Toronto, ON |
| 6 | Sat Apr 29 | atLightning | W2-1 (OT) | 4-2 | .667 | AMALIE Arena · Tampa, FL |
| 1 | Tue May 2 | vsPanthers | L2-4 | 0-1 | .000 | Scotiabank Arena · Toronto, ON |
| 2 | Thu May 4 | vsPanthers | L2-3 | 0-2 | .000 | Scotiabank Arena · Toronto, ON |
| 3 | Sun May 7 | atPanthers | L2-3 (OT) | 0-3 | .000 | Amerant Bank Arena · Sunrise, FL |
| 4 | Wed May 10 | atPanthers | W2-1 | 1-3 | .250 | Amerant Bank Arena · Sunrise, FL |
| 5 | Fri May 12 | vsPanthers | L2-3 (OT) | 1-4 | .200 | Scotiabank Arena · Toronto, ON |
