| 1 | Thu Mar 26 | at Cardinals | L7-9 | 0-1 | .000 | Busch Stadium · St. Louis, MO |
| 2 | Sat Mar 28 | at Cardinals | L5-6 (10) | 0-2 | .000 | Busch Stadium · St. Louis, MO |
| 3 | Sun Mar 29 | at Cardinals | W11-7 | 1-2 | .333 | Busch Stadium · St. Louis, MO |
| 4 | Mon Mar 30 | at Brewers | W3-2 | 2-2 | .500 | American Family Field · Milwaukee, WI |
| 5 | Tue Mar 31 | at Brewers | L2-6 | 2-3 | .400 | American Family Field · Milwaukee, WI |
| 6 | Wed Apr 1 | at Brewers | L2-8 | 2-4 | .333 | American Family Field · Milwaukee, WI |
| 7 | Fri Apr 3 | at Twins | L4-10 | 2-5 | .286 | Target Field · Minneapolis, MN |
| 8 | Sat Apr 4 | at Twins | W7-1 | 3-5 | .375 | Target Field · Minneapolis, MN |
| 9 | Sun Apr 5 | at Twins | W4-1 (10) | 4-5 | .444 | Target Field · Minneapolis, MN |
| 10 | Mon Apr 6 | vs Cubs | W6-4 | 5-5 | .500 | Tropicana Field · St. Petersburg, FL |
| 11 | Tue Apr 7 | vs Cubs | L2-9 | 5-6 | .455 | Tropicana Field · St. Petersburg, FL |
| 12 | Wed Apr 8 | vs Cubs | L2-6 | 5-7 | .417 | Tropicana Field · St. Petersburg, FL |
| 13 | Fri Apr 10 | vs Yankees | W5-3 | 6-7 | .462 | Tropicana Field · St. Petersburg, FL |
| 14 | Sat Apr 11 | vs Yankees | W5-4 (10) | 7-7 | .500 | Tropicana Field · St. Petersburg, FL |
| 15 | Sun Apr 12 | vs Yankees | W5-4 | 8-7 | .533 | Tropicana Field · St. Petersburg, FL |
| 16 | Tue Apr 14 | at White Sox | W8-5 | 9-7 | .563 | Guaranteed Rate Field · Chicago, IL |
| 17 | Wed Apr 15 | at White Sox | W8-3 | 10-7 | .588 | Guaranteed Rate Field · Chicago, IL |
| 18 | Thu Apr 16 | at White Sox | W5-3 | 11-7 | .611 | Guaranteed Rate Field · Chicago, IL |
| 19 | Fri Apr 17 | at Pirates | L1-5 | 11-8 | .579 | PNC Park · Pittsburgh, PA |
| 20 | Sat Apr 18 | at Pirates | W8-7 (13) | 12-8 | .600 | PNC Park · Pittsburgh, PA |
| 21 | Sun Apr 19 | at Pirates | L3-6 | 12-9 | .571 | PNC Park · Pittsburgh, PA |
| 22 | Mon Apr 20 | vs Reds | L1-6 | 12-10 | .545 | Tropicana Field · St. Petersburg, FL |
| 23 | Tue Apr 21 | vs Reds | L6-12 | 12-11 | .522 | Tropicana Field · St. Petersburg, FL |
| 24 | Wed Apr 22 | vs Reds | W6-1 | 13-11 | .542 | Tropicana Field · St. Petersburg, FL |
| 25 | Fri Apr 24 | vs Twins | W6-2 | 14-11 | .560 | Tropicana Field · St. Petersburg, FL |
| 26 | Sat Apr 25 | vs Twins | W6-1 | 15-11 | .577 | Tropicana Field · St. Petersburg, FL |
| 27 | Sun Apr 26 | vs Twins | W4-2 | 16-11 | .593 | Tropicana Field · St. Petersburg, FL |
| 28 | Mon Apr 27 | at Guardians | W3-2 | 17-11 | .607 | Progressive Field · Cleveland, OH |
| 29 | Tue Apr 28 | at Guardians | W1-0 | 18-11 | .621 | Progressive Field · Cleveland, OH |
| 30 | Wed Apr 29 | at Guardians | L1-3 | 18-12 | .600 | Progressive Field · Cleveland, OH |
| 31 | Fri May 1 | vs Giants | W3-0 | 19-12 | .613 | Tropicana Field · St. Petersburg, FL |
| 32 | Sat May 2 | vs Giants | W5-1 | 20-12 | .625 | Tropicana Field · St. Petersburg, FL |
| 33 | Sun May 3 | vs Giants | W2-1 (10) | 21-12 | .636 | Tropicana Field · St. Petersburg, FL |
| 34 | Mon May 4 | vs Blue Jays | W5-1 | 22-12 | .647 | Tropicana Field · St. Petersburg, FL |
| 35 | Tue May 5 | vs Blue Jays | W4-3 | 23-12 | .657 | Tropicana Field · St. Petersburg, FL |
| 36 | Wed May 6 | vs Blue Jays | W3-0 | 24-12 | .667 | Tropicana Field · St. Petersburg, FL |
| 37 | Thu May 7 | at Red Sox | W8-4 | 25-12 | .676 | Fenway Park · Boston, MA |
| 38 | Fri May 8 | at Red Sox | L0-2 | 25-13 | .658 | Fenway Park · Boston, MA |
| 39 | Sun May 10 | at Red Sox | W4-1 | 26-13 | .667 | Fenway Park · Boston, MA |
| 40 | Mon May 11 | at Blue Jays | W8-5 | 27-13 | .675 | Rogers Centre · Toronto, ON |
| 41 | Tue May 12 | at Blue Jays | W7-6 (10) | 28-13 | .683 | Rogers Centre · Toronto, ON |
| 42 | Wed May 13 | at Blue Jays | L3-5 (10) | 28-14 | .667 | Rogers Centre · Toronto, ON |
| 43 | Fri May 15 | vs Marlins | W7-2 | 29-14 | .674 | Tropicana Field · St. Petersburg, FL |
| 44 | Sat May 16 | vs Marlins | L5-10 (10) | 29-15 | .659 | Tropicana Field · St. Petersburg, FL |
| 45 | Sun May 17 | vs Marlins | W6-3 | 30-15 | .667 | Tropicana Field · St. Petersburg, FL |
| 46 | Mon May 18 | vs Orioles | W16-6 | 31-15 | .674 | Tropicana Field · St. Petersburg, FL |
| 47 | Tue May 19 | vs Orioles | W4-1 | 32-15 | .681 | Tropicana Field · St. Petersburg, FL |
| 48 | Wed May 20 | vs Orioles | W5-3 | 33-15 | .688 | Tropicana Field · St. Petersburg, FL |
| 49 | Fri May 22 | at Yankees | W4-2 | 34-15 | .694 | Yankee Stadium · The Bronx, NY |
| 50 | Sun May 24 | at Yankees | L0-2 | 34-16 | .680 | Yankee Stadium · The Bronx, NY |
| 51 | Mon May 25 | at Orioles | L7-9 (13) | 34-17 | .667 | Camden Yards · Baltimore, MD |
| 52 | Tue May 26 | at Orioles | L1-6 | 34-18 | .654 | Camden Yards · Baltimore, MD |
| 53 | Wed May 27 | at Orioles | L2-11 | 34-19 | .642 | Camden Yards · Baltimore, MD |
| 54 | Fri May 29 | vs Angels | W8-5 | 35-19 | .648 | Tropicana Field · St. Petersburg, FL |
| 55 | Sat May 30 | vs Angels | L3-14 | 35-20 | .636 | Tropicana Field · St. Petersburg, FL |
| 56 | Sun May 31 | vs Angels | W5-2 | 36-20 | .643 | Tropicana Field · St. Petersburg, FL |
| 57 | Mon Jun 1 | vs Tigers | L9-10 | 36-21 | .632 | Tropicana Field · St. Petersburg, FL |
| 58 | Tue Jun 2 | vs Tigers | L0-8 | 36-22 | .621 | Tropicana Field · St. Petersburg, FL |
| 59 | Wed Jun 3 | vs Tigers | L2-7 | 36-23 | .610 | Tropicana Field · St. Petersburg, FL |
| 60 | Fri Jun 5 | at Marlins | W6-0 | 37-23 | .617 | LoanDepot Park · Miami, FL |
| 61 | Sat Jun 6 | at Marlins | L3-4 | 37-24 | .607 | LoanDepot Park · Miami, FL |
| 62 | Sun Jun 7 | at Marlins | L1-4 | 37-25 | .597 | LoanDepot Park · Miami, FL |
| 63 | Mon Jun 8 | vs Red Sox | W3-1 | 38-25 | .603 | Tropicana Field · St. Petersburg, FL |
| 64 | Tue Jun 9 | vs Red Sox | W4-3 | 39-25 | .609 | Tropicana Field · St. Petersburg, FL |
| 65 | Wed Jun 10 | vs Red Sox | W7-5 | 40-25 | .615 | Tropicana Field · St. Petersburg, FL |
| 66 | Fri Jun 12 | at Angels | L3-4 | 40-26 | .606 | Angel Stadium · Anaheim, CA |
| 67 | Sat Jun 13 | at Angels | L0-8 | 40-27 | .597 | Angel Stadium · Anaheim, CA |
| 68 | Sun Jun 14 | at Angels | W8-3 | 41-27 | .603 | Angel Stadium · Anaheim, CA |
| 69 | Mon Jun 15 | at Dodgers | L3-4 | 41-28 | .594 | Dodger Stadium · Los Angeles, CA |
| 70 | Tue Jun 16 | at Dodgers | L0-1 | 41-29 | .586 | Dodger Stadium · Los Angeles, CA |
| 71 | Wed Jun 17 | at Dodgers | L4-5 | 41-30 | .577 | Dodger Stadium · Los Angeles, CA |
| 72 | Fri Jun 19 | vs Nationals | W5-2 | 42-30 | .583 | Tropicana Field · St. Petersburg, FL |
| 73 | Sat Jun 20 | vs Nationals | L3-4 | 42-31 | .575 | Tropicana Field · St. Petersburg, FL |
| 74 | Sun Jun 21 | vs Nationals | W4-3 | 43-31 | .581 | Tropicana Field · St. Petersburg, FL |
| 75 | Mon Jun 22 | vs Royals | L1-2 | 43-32 | .573 | Tropicana Field · St. Petersburg, FL |
| 76 | Tue Jun 23 | vs Royals | L5-12 | 43-33 | .566 | Tropicana Field · St. Petersburg, FL |
| 77 | Wed Jun 24 | vs Royals | W5-3 | 44-33 | .571 | Tropicana Field · St. Petersburg, FL |
| 78 | Thu Jun 25 | vs Royals | W13-2 | 45-33 | .577 | Tropicana Field · St. Petersburg, FL |
| 79 | Fri Jun 26 | vs D-backs | W6-1 | 46-33 | .582 | Tropicana Field · St. Petersburg, FL |
| 80 | Sat Jun 27 | vs D-backs | W4-2 | 47-33 | .588 | Tropicana Field · St. Petersburg, FL |
| 81 | Sun Jun 28 | vs D-backs | W5-1 | 48-33 | .593 | Tropicana Field · St. Petersburg, FL |
| 82 | Tue Jun 30 | at Royals | W10-4 | 49-33 | .598 | Kauffman Stadium · Kansas City, MO |
| 83 | Wed Jul 1 | at Royals | W4-0 | 50-33 | .602 | Kauffman Stadium · Kansas City, MO |
| 84 | Thu Jul 2 | at Royals | W5-2 | 51-33 | .607 | Kauffman Stadium · Kansas City, MO |
| 85 | Fri Jul 3 | at Astros | W3-1 | 52-33 | .612 | Minute Maid Park · Houston, TX |
| 86 | Sat Jul 4 | at Astros | L8-10 | 52-34 | .605 | Minute Maid Park · Houston, TX |
| 87 | Sun Jul 5 | at Astros | L0-2 | 52-35 | .598 | Minute Maid Park · Houston, TX |
| 88 | Mon Jul 6 | vs Yankees | L1-5 | 52-36 | .591 | Tropicana Field · St. Petersburg, FL |
| 89 | Tue Jul 7 | vs Yankees | W6-4 | 53-36 | .596 | Tropicana Field · St. Petersburg, FL |
| 90 | Wed Jul 8 | vs Yankees | W3-0 | 54-36 | .600 | Tropicana Field · St. Petersburg, FL |
| 91 | Thu Jul 9 | vs Yankees | L4-12 | 54-37 | .593 | Tropicana Field · St. Petersburg, FL |
| 92 | Fri Jul 10 | vs Mariners | W7-2 | 55-37 | .598 | Tropicana Field · St. Petersburg, FL |
| 93 | Sat Jul 11 | vs Mariners | W6-1 | 56-37 | .602 | Tropicana Field · St. Petersburg, FL |
| 94 | Sun Jul 12 | vs Mariners | L2-8 | 56-38 | .596 | Tropicana Field · St. Petersburg, FL |