| 1 | Tue Nov 9 | vs TBD | W85-50 | 1-0 | 1.000 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 2 | Fri Nov 12 | vsTBD | W68-67 | 2-0 | 1.000 | - | | Cameron Indoor Stadium · Durham, NC |
| 3 | Sat Nov 13 | atDuke | L56-67 | 2-1 | .667 | - | | Cameron Indoor Stadium · Durham, NC |
| 4 | Thu Nov 18 | atMarshall | W67-65 | 3-1 | .750 | - | | Cam Henderson Center · Huntington, WV |
| 5 | Wed Nov 24 | vsMD-Eastern | W66-55 | 4-1 | .800 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 6 | Sat Nov 27 | atStetson | W60-58 | 5-1 | .833 | - | | Edmunds Center · Deland, FL |
| 7 | Tue Nov 30 | vsTBD | W83-39 | 6-1 | .857 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 8 | Sat Dec 4 | atVCU | L61-65 | 6-2 | .750 | - | | Stuart C. Siegel Center · Richmond, VA |
| 9 | Tue Dec 7 | vsTBD | W74-56 | 7-2 | .778 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 10 | Wed Dec 15 | vsGeorgia So | L66-69 | 7-3 | .700 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 11 | Wed Dec 22 | atUNC Wilmington | L58-65 | 7-4 | .636 | - | | Trask Coliseum · Wilmington, NC |
| 14 | Wed Jan 5 | vsUNC Asheville | L54-60 | 7-5 | .583 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 15 | Mon Jan 10 | atWinthrop | L72-74 | 7-6 | .538 | - | | Winthrop Coliseum · Rock Hill, SC |
| 16 | Wed Jan 12 | vsCharleston So | W67-52 | 8-6 | .571 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 17 | Sat Jan 15 | vsRadford | W70-58 | 9-6 | .600 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 18 | Wed Jan 19 | atLongwood | L64-72 | 9-7 | .563 | - | | Willett Hall · Farmville, VA |
| 19 | Sat Jan 22 | atNC A&T | W73-72 | 10-7 | .588 | - | | Corbett Sports Center · Greensboro, NC |
| 20 | Wed Jan 26 | vsHampton | W75-60 | 11-7 | .611 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 21 | Sat Jan 29 | vsHigh Point | W77-72 | 12-7 | .632 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 22 | Wed Feb 2 | atPresbyterian | L58-64 | 12-8 | .600 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 23 | Sat Feb 5 | atSC Upstate | W80-71 | 13-8 | .619 | - | | G.B. Hodge Center · Spartanburg, SC |
| 24 | Wed Feb 9 | vsGardner-Webb | L45-57 | 13-9 | .591 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 25 | Sat Feb 12 | atHigh Point | W60-42 | 14-9 | .609 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 26 | Wed Feb 16 | atRadford | L67-71 | 14-10 | .583 | - | | Donald N. Dedmon Center · Radford, VA |
| 27 | Sat Feb 19 | vsNC A&T | W64-63 | 15-10 | .600 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 28 | Wed Feb 23 | atHampton | L66-68 | 15-11 | .577 | - | | Convocation Center (VA) · Hampton, VA |
| 29 | Sat Feb 26 | vsLongwood | L55-60 | 15-12 | .556 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 30 | Wed Mar 2 | vsPresbyterian | W75-72 (2OT) | 16-12 | .571 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 31 | Fri Mar 4 | atGardner-Webb | L53-54 | 16-13 | .552 | - | | Paul Porter Arena · Boiling Springs, NC |
