| 1 | Wed Nov 10 | vs North Florida | W64-46 | 1-0 | 1.000 | - | | Reed Arena · College Station, TX |
| 2 | Fri Nov 12 | vsAbilene Chrstn | W81-80 (2OT) | 2-0 | 1.000 | - | | Reed Arena · College Station, TX |
| 3 | Sun Nov 14 | vsTexas A&M-CC | W86-65 | 3-0 | 1.000 | - | | Reed Arena · College Station, TX |
| 4 | Wed Nov 17 | vsHou Christian | W73-39 | 4-0 | 1.000 | - | | Reed Arena · College Station, TX |
| 5 | Mon Nov 22 | atWisconsin | L58-69 | 4-1 | .800 | - | ESPN2 | Kohl Center · Madison, WI |
| 6 | Tue Nov 23 | atButler | W57-50 | 5-1 | .833 | - | ESPN2 | Hinkle Fieldhouse · Indianapolis, IN |
| 7 | Wed Nov 24 | atNotre Dame | W73-67 | 6-1 | .857 | - | ESPNU | Purcell Pavilion · South Bend, IN |
| 8 | Tue Nov 30 | vsNew Orleans | W85-65 | 7-1 | .875 | - | | Reed Arena · College Station, TX |
| 9 | Sat Dec 11 | vsTCU | L64-68 | 7-2 | .778 | - | SEC Network | Toyota Center · Houston, TX |
| 11 | Sat Dec 18 | atOregon St | W83-73 | 8-2 | .800 | - | PACN | Gill Coliseum · Corvallis, OR |
| 12 | Tue Dec 21 | vsN'Western St | W80-61 | 9-2 | .818 | - | | Reed Arena · College Station, TX |
| 13 | Mon Dec 27 | vsTBD | W102-52 | 10-2 | .833 | - | | Reed Arena · College Station, TX |
| 14 | Wed Dec 29 | vsC Arkansas | W85-59 | 11-2 | .846 | - | | Reed Arena · College Station, TX |
| 15 | Tue Jan 4 | atGeorgia | W81-79 | 12-2 | .857 | - | ESPNU | Stegeman Coliseum · Athens, GA |
| 16 | Sat Jan 8 | vsArkansas | W86-81 | 13-2 | .867 | - | SEC Network | Reed Arena · College Station, TX |
| 17 | Tue Jan 11 | vsOle Miss | W67-51 | 14-2 | .875 | - | SEC Network | Reed Arena · College Station, TX |
| 18 | Sat Jan 15 | atMissouri | W67-64 | 15-2 | .882 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 19 | Wed Jan 19 | vs12Kentucky | L58-64 | 15-3 | .833 | - | SEC Network | Reed Arena · College Station, TX |
| 20 | Sat Jan 22 | atArkansas | L73-76 (OT) | 15-4 | .789 | - | SEC Network | Bud Walton Arena · Fayetteville, AR |
| 21 | Wed Jan 26 | at19LSU | L64-70 | 15-5 | .750 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 22 | Sat Jan 29 | vsSouth Carolina | L63-74 | 15-6 | .714 | - | SEC Network | Reed Arena · College Station, TX |
| 23 | Tue Feb 1 | at22Tennessee | L80-90 | 15-7 | .682 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 24 | Sat Feb 5 | vsMissouri | L66-70 | 15-8 | .652 | - | ESPN2 | Reed Arena · College Station, TX |
| 25 | Tue Feb 8 | vsLSU | L68-76 | 15-9 | .625 | - | SEC Network | Reed Arena · College Station, TX |
| 26 | Sat Feb 12 | at1Auburn | L58-75 | 15-10 | .600 | - | ESPN | Neville Arena · Auburn, AL |
| 27 | Tue Feb 15 | vsFlorida | W56-55 | 16-10 | .615 | - | SEC Network | Reed Arena · College Station, TX |
| 28 | Sat Feb 19 | atVanderbilt | L67-72 | 16-11 | .593 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 29 | Tue Feb 22 | vsGeorgia | W91-77 | 17-11 | .607 | - | ESPNU | Reed Arena · College Station, TX |
| 30 | Sat Feb 26 | atOle Miss | W76-66 | 18-11 | .621 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 31 | Wed Mar 2 | at25Alabama | W87-71 | 19-11 | .633 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 32 | Sat Mar 5 | vsMississippi St | W67-64 | 20-11 | .645 | - | SEC Network | Reed Arena · College Station, TX |
| 33 | Thu Mar 10 | vsFlorida | W83-80 (OT) | 21-11 | .656 | - | SEC Network | Benchmark International Arena · Tampa, FL |
| 34 | Fri Mar 11 | atAuburn | W67-62 | 22-11 | .667 | - | ESPN | Benchmark International Arena · Tampa, FL |
| 35 | Sat Mar 12 | atArkansas | W82-64 | 23-11 | .676 | - | ESPN | Benchmark International Arena · Tampa, FL |
| 36 | Sun Mar 13 | atTennessee | L50-65 | 23-12 | .657 | - | ESPN | Benchmark International Arena · Tampa, FL |
| 36 | Tue Mar 15 | vsAlcorn St | W74-62 | 24-12 | .667 | - | ESPN2 | Reed Arena · College Station, TX |
| 37 | Sat Mar 19 | vsOregon | W75-60 | 25-12 | .676 | - | ESPN | Reed Arena · College Station, TX |
| 38 | Wed Mar 23 | vsWake Forest | W67-52 | 26-12 | .684 | - | ESPN2 | Reed Arena · College Station, TX |
| 39 | Tue Mar 29 | vsWashington St | W72-56 | 27-12 | .692 | - | ESPN2 | Reed Arena · College Station, TX |
| 40 | Thu Mar 31 | vsXavier | L72-73 | 27-13 | .675 | - | ESPN | Reed Arena · College Station, TX |
