| 1 | Tue Nov 5 | vs N Colorado | W69-45 | 1-0 | 1.000 | - | LHN | Moody Center · Austin, TX |
| 2 | Sat Nov 9 | at23Purdue | W70-66 | 2-0 | 1.000 | - | FS1 | Mackey Arena · West Lafayette, IN |
| 3 | Tue Nov 12 | vsCA Baptist | W67-54 | 3-0 | 1.000 | - | LHN | Moody Center · Austin, TX |
| 4 | Fri Nov 15 | vsPrairie View | W70-56 | 4-0 | 1.000 | - | LHN | Moody Center · Austin, TX |
| 5 | Thu Nov 21 | vsGeorgetown | L66-82 | 4-1 | .800 | - | ESPN2 | Moody Center · Austin, TX |
| 6 | Fri Nov 22 | atCalifornia | W62-45 | 5-1 | .833 | - | ESPN2 | Haas Pavilion · Berkeley, CA |
| 7 | Sat Nov 30 | vsMcNeese | W73-71 | 6-1 | .857 | - | LHN | Moody Center · Austin, TX |
| 8 | Tue Dec 3 | vsUAB | W67-57 | 7-1 | .875 | - | LHN | Moody Center · Austin, TX |
| 9 | Sun Dec 8 | vsTexas A&M | W60-50 | 8-1 | .889 | - | ABC | Moody Center · Austin, TX |
| 10 | Sat Dec 14 | vsC Michigan | W87-76 | 9-1 | .900 | - | LHN | Moody Center · Austin, TX |
| 11 | Sat Dec 21 | atProvidence | L48-70 | 9-2 | .818 | - | FOX | Amica Mutual Pavilion · Providence, RI |
| 12 | Mon Dec 30 | vsHigh Point | W89-58 | 10-2 | .833 | - | LHN | Moody Center · Austin, TX |
| 13 | Sat Jan 4 | at6Baylor | L44-59 | 10-3 | .769 | - | ESPN2 | Ferrell Center · Waco, TX |
| 14 | Wed Jan 8 | vsOklahoma | L62-72 | 10-4 | .714 | - | ESPN2 | Moody Center · Austin, TX |
| 15 | Sat Jan 11 | vsKansas St | W64-50 | 11-4 | .733 | - | LHN | Moody Center · Austin, TX |
| 16 | Wed Jan 15 | atOklahoma St | W76-64 | 12-4 | .750 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 17 | Sat Jan 18 | vs6Kansas | L57-66 | 12-5 | .706 | - | ESPN | Moody Center · Austin, TX |
| 18 | Mon Jan 20 | at14West Virginia | L59-97 | 12-6 | .667 | - | ESPNU | WVU Coliseum · Morgantown, WV |
| 19 | Sat Jan 25 | vsLSU | L67-69 | 12-7 | .632 | - | ESPN | Moody Center · Austin, TX |
| 20 | Wed Jan 29 | atTCU | W62-61 | 13-7 | .650 | - | | Schollmaier Arena · Fort Worth, TX |
| 21 | Sat Feb 1 | vsIowa State | W72-68 | 14-7 | .667 | - | LHN | Moody Center · Austin, TX |
| 22 | Mon Feb 3 | at3Kansas | L58-69 | 14-8 | .636 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 23 | Sat Feb 8 | vsTexas Tech | L57-62 | 14-9 | .609 | - | ESPN2 | Moody Center · Austin, TX |
| 24 | Mon Feb 10 | vs1Baylor | L45-52 | 14-10 | .583 | - | ESPN | Moody Center · Austin, TX |
| 25 | Sat Feb 15 | atIowa State | L52-81 | 14-11 | .560 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 26 | Wed Feb 19 | vsTCU | W70-56 | 15-11 | .577 | - | LHN | Moody Center · Austin, TX |
| 27 | Sat Feb 22 | atKansas St | W70-59 | 16-11 | .593 | - | CBS | Bramlage Coliseum · Manhattan, KS |
| 28 | Mon Feb 24 | vs20West Virginia | W67-57 | 17-11 | .607 | - | ESPNU | Moody Center · Austin, TX |
| 29 | Sat Feb 29 | at22Texas Tech | W68-58 | 18-11 | .621 | - | ESPN | United Supermarkets Arena · Lubbock, TX |
| 30 | Tue Mar 3 | atOklahoma | W52-51 | 19-11 | .633 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 31 | Sat Mar 7 | vsOklahoma St | L59-81 | 19-12 | .613 | - | ESPN2 | Moody Center · Austin, TX |
