| 1 | Mon Nov 6 | vs Incarnate Word | W88-56 | 1-0 | 1.000 | #18 | LHN | Moody Center · Austin, TX |
| 2 | Fri Nov 10 | vsDelaware St | W86-59 | 2-0 | 1.000 | #18 | LHN | Moody Center · Austin, TX |
| 3 | Wed Nov 15 | vsRice | W80-64 | 3-0 | 1.000 | #19 | LHN | Moody Center · Austin, TX |
| 4 | Sun Nov 19 | atLouisville | W81-80 | 4-0 | 1.000 | #19 | ESPN | KFC Yum! Center · Louisville, KY |
| 5 | Mon Nov 20 | vs5UConn | L71-81 | 4-1 | .800 | #15 | ESPNU | Moody Center · Austin, TX |
| 6 | Sun Nov 26 | vsWyoming | W86-63 | 5-1 | .833 | #15 | LHN | Moody Center · Austin, TX |
| 7 | Thu Nov 30 | vsTexas St | W77-58 | 6-1 | .857 | #16 | LHN | Moody Center · Austin, TX |
| 8 | Wed Dec 6 | at8Marquette | L65-86 | 6-2 | .750 | #12 | FS1 | Fiserv Forum · Milwaukee, WI |
| 9 | Sat Dec 9 | vsHou Christian | W77-50 | 7-2 | .778 | #12 | LHN | Moody Center · Austin, TX |
| 10 | Sat Dec 16 | vsLSU | W96-85 | 8-2 | .800 | #19 | ESPN2 | Toyota Center · Houston, TX |
| 11 | Fri Dec 22 | vsTexas A&M-CC | W71-55 | 9-2 | .818 | #19 | LHN | Moody Center · Austin, TX |
| 12 | Fri Dec 29 | vsUNC Greensboro | W72-37 | 10-2 | .833 | #21 | LHN | Moody Center · Austin, TX |
| 13 | Mon Jan 1 | vsUT Arlington | W79-62 | 11-2 | .846 | #20 | LHN | Moody Center · Austin, TX |
| 14 | Sat Jan 6 | vsTexas Tech | L67-78 | 11-3 | .786 | #20 | ESPN2 | Moody Center · Austin, TX |
| 15 | Tue Jan 9 | atCincinnati | W74-73 | 12-3 | .800 | #25 | | Fifth Third Arena · Cincinnati, OH |
| 16 | Sat Jan 13 | atWest Virginia | L73-76 | 12-4 | .750 | #25 | | WVU Coliseum · Morgantown, WV |
| 17 | Wed Jan 17 | vsUCF | L71-77 | 12-5 | .706 | - | LHN | Moody Center · Austin, TX |
| 18 | Sat Jan 20 | vs9Baylor | W75-73 | 13-5 | .722 | - | ESPN | Moody Center · Austin, TX |
| 19 | Tue Jan 23 | at11Oklahoma | W75-60 | 14-5 | .737 | - | ESPN | Lloyd Noble Center · Norman, OK |
| 20 | Sat Jan 27 | at21BYU | L72-84 | 14-6 | .700 | - | ESPN2 | Marriott Center · Provo, UT |
| 21 | Mon Jan 29 | vs4Houston | L72-76 (OT) | 14-7 | .667 | - | ESPN | Moody Center · Austin, TX |
| 22 | Sat Feb 3 | at25TCU | W77-66 | 15-7 | .682 | - | ESPN2 | Schollmaier Arena · Fort Worth, TX |
| 23 | Tue Feb 6 | vs14Iowa State | L65-70 | 15-8 | .652 | - | LHN | Moody Center · Austin, TX |
| 24 | Sat Feb 10 | vsWest Virginia | W94-58 | 16-8 | .667 | - | LHN | Moody Center · Austin, TX |
| 25 | Sat Feb 17 | at3Houston | L61-82 | 16-9 | .640 | - | CBS | Fertitta Center · Houston, TX |
| 26 | Mon Feb 19 | vsKansas St | W62-56 | 17-9 | .654 | - | ESPN2 | Moody Center · Austin, TX |
| 27 | Sat Feb 24 | at9Kansas | L67-86 | 17-10 | .630 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 28 | Tue Feb 27 | atTexas Tech | W81-69 | 18-10 | .643 | - | ESPN | United Supermarkets Arena · Lubbock, TX |
| 29 | Sat Mar 2 | vsOklahoma St | W81-65 | 19-10 | .655 | - | ESPN2 | Moody Center · Austin, TX |
| 30 | Mon Mar 4 | at11Baylor | L85-93 | 19-11 | .633 | - | ESPN | Ferrell Center · Waco, TX |
| 31 | Sat Mar 9 | vsOklahoma | W94-80 | 20-11 | .645 | - | ESPN | Moody Center · Austin, TX |
| 32 | Wed Mar 13 | vsKansas St | L74-78 | 20-12 | .625 | - | | T-Mobile Center · Kansas City, MOS |
| 33 | Thu Mar 21 | vs10Colorado St | W56-44 | 21-12 | .636 | #7 | TNT | Moody Center · Austin, TX |
| 34 | Sat Mar 23 | at2Tennessee | L58-62 | 21-13 | .618 | #7 | CBS | Thompson-Boling Arena · Knoxville, TN |
