| 1 | Mon Nov 7 | vs UTEP | W72-57 | 1-0 | 1.000 | #12 | LHN | Moody Center · Austin, TX |
| 2 | Thu Nov 10 | vs Hou Christian | W82-31 | 2-0 | 1.000 | #12 | LHN | Moody Center · Austin, TX |
| 3 | Wed Nov 16 | vs #2Gonzaga | W93-74 | 3-0 | 1.000 | #11 | ESPN2 | Moody Center · Austin, TX |
| 4 | Mon Nov 21 | at N Arizona | W73-48 | 4-0 | 1.000 | - | LHN | J. Lawrence Walkup Skydome · Flagstaff, AZ |
| 5 | Sat Nov 26 | vs UT Rio Grande | W91-54 | 5-0 | 1.000 | - | LHN | Moody Center · Austin, TX |
| 6 | Thu Dec 1 | vs Creighton | W72-67 | 6-0 | 1.000 | - | ESPN | Moody Center · Austin, TX |
| 7 | Tue Dec 6 | vs Illinois | L78-85 (OT) | 6-1 | .857 | - | ESPN | Moody Center · Austin, TX |
| 8 | Sat Dec 10 | vs AR-Pine Bluff | W88-43 | 7-1 | .875 | - | LHN | Moody Center · Austin, TX |
| 9 | Mon Dec 12 | vs Rice | W87-81 (OT) | 8-1 | .889 | #7 | LHN | Moody Center · Austin, TX |
| 10 | Sun Dec 18 | vs Stanford | W72-62 | 9-1 | .900 | - | ESPN2 | Moody Center · Austin, TX |
| 11 | Wed Dec 21 | vs Louisiana | W100-72 | 10-1 | .909 | #7 | LHN | Moody Center · Austin, TX |
| 12 | Tue Dec 27 | vs E Texas A&M | W97-72 | 11-1 | .917 | #6 | LHN | Moody Center · Austin, TX |
| 13 | Sat Dec 31 | at Oklahoma | W70-69 | 12-1 | .923 | #6 | | Lloyd Noble Center · Norman, OK |
| 14 | Tue Jan 3 | vs Kansas St | L103-116 | 12-2 | .857 | #6 | LHN | Moody Center · Austin, TX |
| 15 | Sat Jan 7 | at Oklahoma St | W56-46 | 13-2 | .867 | #6 | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 16 | Wed Jan 11 | vs #17TCU | W79-75 | 14-2 | .875 | #10 | ESPN2 | Moody Center · Austin, TX |
| 17 | Sat Jan 14 | vs Texas Tech | W72-70 | 15-2 | .882 | #10 | ESPN | Moody Center · Austin, TX |
| 18 | Tue Jan 17 | at #12Iowa State | L67-78 | 15-3 | .833 | #7 | | James H. Hilton Coliseum · Ames, IA |
| 19 | Sat Jan 21 | at West Virginia | W69-61 | 16-3 | .842 | #7 | ESPN | WVU Coliseum · Morgantown, WV |
| 20 | Tue Jan 24 | vsOklahoma St | W89-75 | 17-3 | .850 | #10 | LHN | Moody Center · Austin, TX |
| 21 | Sat Jan 28 | at Tennessee | L71-82 | 17-4 | .810 | - | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 22 | Mon Jan 30 | vs #11Baylor | W76-71 | 18-4 | .818 | #10 | ESPN | Moody Center · Austin, TX |
| 23 | Sat Feb 4 | at#7Kansas St | W69-66 | 19-4 | .826 | #10 | ESPN2 | Bramlage Coliseum · Manhattan, KS |
| 24 | Mon Feb 6 | at #9Kansas | L80-88 | 19-5 | .792 | #5 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 25 | Sat Feb 11 | vsWest Virginia | W94-60 | 20-5 | .800 | #5 | ESPN2 | Moody Center · Austin, TX |
| 26 | Mon Feb 13 | atTexas Tech | L67-74 | 20-6 | .769 | #6 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 27 | Sat Feb 18 | vsOklahoma | W85-83 (OT) | 21-6 | .778 | #6 | | Moody Center · Austin, TX |
| 28 | Tue Feb 21 | vs#23Iowa State | W72-54 | 22-6 | .786 | #8 | LHN | Moody Center · Austin, TX |
| 29 | Sat Feb 25 | at#9Baylor | L72-81 | 22-7 | .759 | #8 | ESPN | Ferrell Center · Waco, TX |
| 30 | Wed Mar 1 | at#22TCU | L73-75 | 22-8 | .733 | #9 | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 31 | Sat Mar 4 | vs#3Kansas | W75-59 | 23-8 | .742 | #9 | ESPN | Moody Center · Austin, TX |
| 32 | Thu Mar 9 | vsOklahoma St | W61-47 | 24-8 | .750 | - | ESPN2 | Moody Center · Austin, TX |
| 33 | Fri Mar 10 | vsTCU | W66-60 | 25-8 | .758 | - | ESPN | Moody Center · Austin, TX |
| 34 | Sat Mar 11 | atKansas | W76-56 | 26-8 | .765 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 35 | Thu Mar 16 | vs #15Colgate | W81-61 | 27-8 | .771 | #2 | TBS | Moody Center · Austin, TX |
| 36 | Sat Mar 18 | vs #10Penn State | W71-66 | 28-8 | .778 | #2 | CBS | Moody Center · Austin, TX |
| 37 | Fri Mar 24 | vs #3Xavier | W83-71 | 29-8 | .784 | #2 | CBS | Moody Center · Austin, TX |
| 38 | Sun Mar 26 | vs #5Miami | L81-88 | 29-9 | .763 | #2 | CBS | Moody Center · Austin, TX |
