| 1 | Wed Nov 25 | vs UT Rio Grande | W91-55 | 1-0 | 1.000 | #19 | LHN | Moody Center · Austin, TX |
| 2 | Mon Nov 30 | atDavidson | W78-76 | 2-0 | 1.000 | - | ESPN2 | John M. Belk Arena · Davidson, NC |
| 3 | Tue Dec 1 | atIndiana | W66-44 | 3-0 | 1.000 | - | ESPN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 4 | Wed Dec 2 | atUNC | W69-67 | 4-0 | 1.000 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 5 | Sun Dec 6 | vsVillanova | L64-68 | 4-1 | .800 | - | ESPN | Moody Center · Austin, TX |
| 6 | Wed Dec 9 | vsTexas St | W74-53 | 5-1 | .833 | #13 | LHN | Moody Center · Austin, TX |
| 8 | Wed Dec 16 | vsSam Houston | W79-63 | 6-1 | .857 | #11 | LHN | Moody Center · Austin, TX |
| 9 | Sun Dec 20 | vsOklahoma St | W77-74 | 7-1 | .875 | #11 | LHN | Moody Center · Austin, TX |
| 11 | Sat Jan 2 | at3Kansas | W84-59 | 8-1 | .889 | #8 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 12 | Tue Jan 5 | vsIowa State | W78-72 | 9-1 | .900 | #4 | LHN | Moody Center · Austin, TX |
| 13 | Sat Jan 9 | at14West Virginia | W72-70 | 10-1 | .909 | #4 | ESPN | WVU Coliseum · Morgantown, WV |
| 14 | Wed Jan 13 | vs15Texas Tech | L77-79 | 10-2 | .833 | #4 | ESPN2 | Moody Center · Austin, TX |
| 15 | Sat Jan 16 | vsKansas St | W82-67 | 11-2 | .846 | #4 | LHN | Moody Center · Austin, TX |
| 16 | Wed Jan 20 | atIowa State | PPD | 19-8 | .704 | #5 | | James H. Hilton Coliseum · Ames, IA |
| 17 | Sat Jan 23 | atTCU | PPD | 19-8 | .704 | #5 | ESPN2 | Schollmaier Arena · Fort Worth, TX |
| 18 | Tue Jan 26 | vs24Oklahoma | L79-80 | 11-3 | .786 | #5 | ESPN2 | Moody Center · Austin, TX |
| 20 | Tue Feb 2 | vs2Baylor | L69-83 | 11-4 | .733 | #6 | ESPN | Moody Center · Austin, TX |
| 21 | Sat Feb 6 | atOklahoma St | L67-75 (2OT) | 11-5 | .688 | #6 | ABC | Gallagher-Iba Arena · Stillwater, OK |
| 22 | Tue Feb 9 | atKansas St | W80-77 | 12-5 | .706 | #13 | | Bramlage Coliseum · Manhattan, KS |
| 23 | Sat Feb 13 | vsTCU | W70-55 | 13-5 | .722 | #13 | LHN | Moody Center · Austin, TX |
| 24 | Thu Feb 18 | at9Oklahoma | PPD | 19-8 | .704 | #12 | | Lloyd Noble Center · Norman, OK |
| 25 | Sat Feb 20 | vs13West Virginia | L82-84 | 13-6 | .684 | #12 | ABC | Moody Center · Austin, TX |
| 26 | Tue Feb 23 | vs17Kansas | W75-72 (OT) | 14-6 | .700 | #14 | ESPN | Moody Center · Austin, TX |
| 27 | Sat Feb 27 | at18Texas Tech | L59-68 | 14-7 | .667 | #14 | CBS | United Supermarkets Arena · Lubbock, TX |
| 28 | Tue Mar 2 | atIowa State | W81-67 | 15-7 | .682 | #15 | | James H. Hilton Coliseum · Ames, IA |
| 29 | Thu Mar 4 | at16Oklahoma | W69-65 | 16-7 | .696 | #15 | ESPN | Lloyd Noble Center · Norman, OK |
| 30 | Sun Mar 7 | atTCU | W76-64 | 17-7 | .708 | #15 | | Schollmaier Arena · Fort Worth, TX |
| 31 | Thu Mar 11 | vsTexas Tech | W67-66 | 18-7 | .720 | - | ESPN2 | T-Mobile Center · Kansas City, MOS |
| 33 | Sat Mar 13 | vsOklahoma St | W91-86 | 19-7 | .731 | - | ESPN | T-Mobile Center · Kansas City, MOS |
| 30 | Sat Mar 20 | vs14Abilene Chrstn | L52-53 | 19-8 | .704 | #3 | truTV | Lucas Oil Stadium · Indianapolis, IN |
