| 1 | Tue Nov 9 | vs Hou Christian | W92-48 | 1-0 | 1.000 | #5 | LHN | Moody Center · Austin, TX |
| 2 | Sat Nov 13 | at1Gonzaga | L74-86 | 1-1 | .500 | #5 | ESPN2 | McCarthey Athletic Center · Spokane, WA |
| 3 | Wed Nov 17 | vsN Colorado | W62-49 | 2-1 | .667 | - | LHN | Moody Center · Austin, TX |
| 4 | Sat Nov 20 | vsSan Jose St | W79-45 | 3-1 | .750 | - | LHN | Moody Center · Austin, TX |
| 5 | Wed Nov 24 | vsCA Baptist | W68-44 | 4-1 | .800 | - | LHN | Moody Center · Austin, TX |
| 6 | Mon Nov 29 | vsSam Houston | W73-57 | 5-1 | .833 | - | LHN | Moody Center · Austin, TX |
| 7 | Fri Dec 3 | vsUT Rio Grande | W88-58 | 6-1 | .857 | #7 | LHN | Moody Center · Austin, TX |
| 8 | Thu Dec 9 | atSeton Hall | L60-64 | 6-2 | .750 | - | FS1 | Prudential Center · Newark, NJ |
| 9 | Tue Dec 14 | vsAR-Pine Bluff | W63-31 | 7-2 | .778 | - | ESPNU | Moody Center · Austin, TX |
| 10 | Sun Dec 19 | atStanford | W60-53 | 8-2 | .800 | - | ABC | T-Mobile Arena · Las Vegas, NV |
| 11 | Wed Dec 22 | vsAlabama St | W68-48 | 9-2 | .818 | #16 | LHN | Moody Center · Austin, TX |
| 12 | Tue Dec 28 | vsIncarnate Word | W78-33 | 10-2 | .833 | #17 | LHN | Moody Center · Austin, TX |
| 13 | Sat Jan 1 | vsWest Virginia | W74-59 | 11-2 | .846 | #17 | ESPNU | Moody Center · Austin, TX |
| 14 | Tue Jan 4 | atKansas St | W70-57 | 12-2 | .857 | #14 | | Bramlage Coliseum · Manhattan, KS |
| 15 | Sat Jan 8 | atOklahoma St | L51-64 | 12-3 | .800 | #14 | CBS | Gallagher-Iba Arena · Stillwater, OK |
| 16 | Tue Jan 11 | vsOklahoma | W66-52 | 13-3 | .813 | #21 | LHN | Moody Center · Austin, TX |
| 17 | Sat Jan 15 | at15Iowa State | L70-79 | 13-4 | .765 | #21 | | James H. Hilton Coliseum · Ames, IA |
| 18 | Tue Jan 18 | vsKansas St | L65-66 | 13-5 | .722 | #23 | LHN | Moody Center · Austin, TX |
| 19 | Sat Jan 22 | vsOklahoma St | W56-51 | 14-5 | .737 | #23 | ESPN2 | Moody Center · Austin, TX |
| 20 | Tue Jan 25 | atTCU | W73-50 | 15-5 | .750 | - | ESPNU | Schollmaier Arena · Fort Worth, TX |
| 21 | Sat Jan 29 | vsTennessee | W52-51 | 16-5 | .762 | - | ESPN | Moody Center · Austin, TX |
| 22 | Tue Feb 1 | at14Texas Tech | L64-77 | 16-6 | .727 | #23 | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 23 | Sat Feb 5 | vs20Iowa State | W63-41 | 17-6 | .739 | #23 | LHN | Moody Center · Austin, TX |
| 24 | Mon Feb 7 | vs8Kansas | W79-76 | 18-6 | .750 | #20 | ESPN | Moody Center · Austin, TX |
| 25 | Sat Feb 12 | atBaylor | L63-80 | 18-7 | .720 | - | ESPN2 | Ferrell Center · Waco, TX |
| 26 | Tue Feb 15 | atOklahoma | W80-78 (OT) | 19-7 | .731 | #20 | ESPN2 | Lloyd Noble Center · Norman, OK |
| 27 | Sat Feb 19 | vs11Texas Tech | L55-61 | 19-8 | .704 | #20 | ABC | Moody Center · Austin, TX |
| 28 | Wed Feb 23 | vsTCU | W75-66 | 20-8 | .714 | #20 | ESPN2 | Moody Center · Austin, TX |
| 29 | Sat Feb 26 | atWest Virginia | W82-81 | 21-8 | .724 | #20 | ESPN2 | WVU Coliseum · Morgantown, WV |
| 30 | Mon Feb 28 | vs3Baylor | L61-68 | 21-9 | .700 | #21 | ESPN | Moody Center · Austin, TX |
| 31 | Sat Mar 5 | at6Kansas | L63-70 (OT) | 21-10 | .677 | #21 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 32 | Thu Mar 10 | vsTCU | L60-65 | 21-11 | .656 | - | ESPN2 | T-Mobile Center · Kansas City, MOS |
| 33 | Fri Mar 18 | vs11Virginia Tech | W81-73 | 22-11 | .667 | #6 | TBS | Fiserv Forum · Milwaukee, WI |
| 34 | Sun Mar 20 | at3Purdue | L71-81 | 22-12 | .647 | #6 | TNT | Fiserv Forum · Milwaukee, WI |
