| 1 | Wed Oct 12 | vs Kraken | W5-4 (OT) | 1-0-0 | 2 PTS | Honda Center · Anaheim, CA |
| 2 | Sat Oct 15 | atIslanders | L1-7 | 1-1-0 | 2 PTS | UBS Arena · Elmont, NY |
| 3 | Mon Oct 17 | atRangers | L4-6 | 1-2-0 | 2 PTS | Madison Square Garden · Manhattan, NY |
| 4 | Tue Oct 18 | atDevils | L2-4 | 1-3-0 | 2 PTS | Prudential Center · Newark, NJ |
| 5 | Thu Oct 20 | atBruins | L1-2 (SO) | 1-3-1 | 3 PTS | TD Garden · Boston, MA |
| 6 | Sun Oct 23 | atRed Wings | L1-5 | 1-4-1 | 3 PTS | Little Caesars Arena · Detroit, MI |
| 7 | Wed Oct 26 | vsLightning | L2-4 | 1-5-1 | 3 PTS | Honda Center · Anaheim, CA |
| 8 | Fri Oct 28 | atKnights | L0-4 | 1-6-1 | 3 PTS | T-Mobile Arena · Las Vegas, NV |
| 9 | Sun Oct 30 | vsMaple Leafs | W4-3 (OT) | 2-6-1 | 5 PTS | Honda Center · Anaheim, CA |
| 10 | Tue Nov 1 | atSharks | W6-5 (SO) | 3-6-1 | 7 PTS | SAP Center · San Jose, CA |
| 11 | Thu Nov 3 | atCanucks | L5-8 | 3-7-1 | 7 PTS | Rogers Arena · Vancouver, British Columbia |
| 12 | Sat Nov 5 | atSharks | W5-4 (SO) | 4-7-1 | 9 PTS | SAP Center · San Jose, CA |
| 13 | Sun Nov 6 | vsPanthers | L3-5 | 4-8-1 | 9 PTS | Honda Center · Anaheim, CA |
| 14 | Wed Nov 9 | vsWild | L1-4 | 4-9-1 | 9 PTS | Honda Center · Anaheim, CA |
| 15 | Sat Nov 12 | vsBlackhawks | L2-3 | 4-10-1 | 9 PTS | Honda Center · Anaheim, CA |
| 16 | Tue Nov 15 | vsRed Wings | W3-2 (OT) | 5-10-1 | 11 PTS | Honda Center · Anaheim, CA |
| 17 | Thu Nov 17 | atJets | L2-3 | 5-11-1 | 11 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 18 | Sat Nov 19 | atBlues | L2-6 | 5-12-1 | 11 PTS | Enterprise Center · St. Louis, MO |
| 19 | Mon Nov 21 | atBlues | L1-3 | 5-13-1 | 11 PTS | Enterprise Center · St. Louis, MO |
| 20 | Wed Nov 23 | vsRangers | W3-2 | 6-13-1 | 13 PTS | Honda Center · Anaheim, CA |
| 21 | Fri Nov 25 | vsSenators | L1-5 | 6-14-1 | 13 PTS | Honda Center · Anaheim, CA |
| 22 | Sun Nov 27 | vsKraken | L4-5 | 6-15-1 | 13 PTS | Honda Center · Anaheim, CA |
| 23 | Tue Nov 29 | atPredators | L1-2 (OT) | 6-15-2 | 14 PTS | Bridgestone Arena · Nashville, TN |
| 24 | Thu Dec 1 | atStars | L0-5 | 6-16-2 | 14 PTS | American Airlines Center · Dallas, TX |
| 25 | Sat Dec 3 | atWild | L4-5 (SO) | 6-16-3 | 15 PTS | Xcel Energy Center · St. Paul, MN |
| 26 | Sun Dec 4 | atJets | L2-5 | 6-17-3 | 15 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 27 | Tue Dec 6 | vsHurricanes | W4-3 (OT) | 7-17-3 | 17 PTS | Honda Center · Anaheim, CA |
| 28 | Fri Dec 9 | vsSharks | L1-6 | 7-18-3 | 17 PTS | Honda Center · Anaheim, CA |
| 29 | Mon Dec 12 | atSenators | L0-3 | 7-19-3 | 17 PTS | Canadian Tire Centre · Ottawa, ON |
| 30 | Tue Dec 13 | atMaple Leafs | L0-7 | 7-20-3 | 17 PTS | Scotiabank Arena · Toronto, ON |
| 31 | Thu Dec 15 | atCanadiens | W5-2 | 8-20-3 | 19 PTS | Bell Centre · Montreal, QC |
| 32 | Sat Dec 17 | atOilers | W4-3 | 9-20-3 | 21 PTS | Rogers Place · Edmonton, AB |
| 33 | Tue Dec 20 | atKings | L1-4 | 9-21-3 | 21 PTS | Crypto.com Arena · Los Angeles, CA |
| 34 | Wed Dec 21 | vsWild | L1-4 | 9-22-3 | 21 PTS | Honda Center · Anaheim, CA |
| 35 | Fri Dec 23 | vsFlames | L2-3 (OT) | 9-22-4 | 22 PTS | Honda Center · Anaheim, CA |
| 36 | Wed Dec 28 | vsKnights | W3-2 (SO) | 10-22-4 | 24 PTS | Honda Center · Anaheim, CA |
| 37 | Fri Dec 30 | vsPredators | L1-6 | 10-23-4 | 24 PTS | Honda Center · Anaheim, CA |
| 38 | Mon Jan 2 | vsFlyers | L1-4 | 10-24-4 | 24 PTS | Honda Center · Anaheim, CA |
| 39 | Wed Jan 4 | vsStars | W2-0 | 11-24-4 | 26 PTS | Honda Center · Anaheim, CA |
| 40 | Fri Jan 6 | vsSharks | W5-4 (OT) | 12-24-4 | 28 PTS | Honda Center · Anaheim, CA |
| 41 | Sun Jan 8 | vsBruins | L1-7 | 12-25-4 | 28 PTS | Honda Center · Anaheim, CA |
| 42 | Wed Jan 11 | vsOilers | L2-6 | 12-26-4 | 28 PTS | Honda Center · Anaheim, CA |
| 43 | Fri Jan 13 | vsDevils | L2-6 | 12-27-4 | 28 PTS | Honda Center · Anaheim, CA |
| 44 | Mon Jan 16 | atPenguins | L3-4 (OT) | 12-27-5 | 29 PTS | PPG Paints Arena · Pittsburgh, PA |
| 45 | Tue Jan 17 | atFlyers | L2-5 | 12-28-5 | 29 PTS | Wells Fargo Center · Philadelphia, PA |
| 46 | Thu Jan 19 | atJackets | W5-3 | 13-28-5 | 31 PTS | Nationwide Arena · Columbus, OH |
| 47 | Sat Jan 21 | atSabres | L3-6 | 13-29-5 | 31 PTS | KeyBank Center · Buffalo, NY |
| 48 | Tue Jan 24 | atCoyotes | W5-2 | 14-29-5 | 33 PTS | Mullett Arena · Tempe, AZ |
| 49 | Thu Jan 26 | atAvalanche | W5-3 | 15-29-5 | 35 PTS | Ball Arena · Denver, CO |
| 50 | Sat Jan 28 | vsCoyotes | W2-1 (OT) | 16-29-5 | 37 PTS | Honda Center · Anaheim, CA |
| 51 | Mon Feb 6 | atStars | L2-3 (SO) | 16-29-6 | 38 PTS | American Airlines Center · Dallas, TX |
| 52 | Tue Feb 7 | atBlackhawks | W3-2 (OT) | 17-29-6 | 40 PTS | United Center · Chicago, IL |
| 53 | Fri Feb 10 | vsPenguins | L3-6 | 17-30-6 | 40 PTS | Honda Center · Anaheim, CA |
| 54 | Sun Feb 12 | atKnights | L2-7 | 17-31-6 | 40 PTS | T-Mobile Arena · Las Vegas, NV |
| 55 | Wed Feb 15 | vsSabres | L3-7 | 17-32-6 | 40 PTS | Honda Center · Anaheim, CA |
| 56 | Fri Feb 17 | vsKings | L3-6 | 17-33-6 | 40 PTS | Honda Center · Anaheim, CA |
| 57 | Mon Feb 20 | atPanthers | L3-4 (OT) | 17-33-7 | 41 PTS | Amerant Bank Arena · Sunrise, FL |
| 58 | Tue Feb 21 | atLightning | L1-6 | 17-34-7 | 41 PTS | AMALIE Arena · Tampa, FL |
| 59 | Thu Feb 23 | atCapitals | W4-2 | 18-34-7 | 43 PTS | Capital One Arena · Washington, D.C. |
| 60 | Sat Feb 25 | atHurricanes | W3-2 | 19-34-7 | 45 PTS | PNC Arena · Raleigh, NC |
| 61 | Mon Feb 27 | vsBlackhawks | W4-2 | 20-34-7 | 47 PTS | Honda Center · Anaheim, CA |
| 62 | Wed Mar 1 | vsCapitals | L2-3 (OT) | 20-34-8 | 48 PTS | Honda Center · Anaheim, CA |
| 63 | Fri Mar 3 | vsCanadiens | W3-2 | 21-34-8 | 50 PTS | Honda Center · Anaheim, CA |
| 64 | Tue Mar 7 | atKraken | L2-5 | 21-35-8 | 50 PTS | Climate Pledge Arena · Seattle, WA |
| 65 | Wed Mar 8 | atCanucks | L2-3 (OT) | 21-35-9 | 51 PTS | Rogers Arena · Vancouver, British Columbia |
| 66 | Fri Mar 10 | atFlames | W3-1 | 22-35-9 | 53 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 67 | Sun Mar 12 | vsPredators | L4-5 (OT) | 22-35-10 | 54 PTS | Honda Center · Anaheim, CA |
| 68 | Wed Mar 15 | vsIslanders | L3-6 | 22-36-10 | 54 PTS | Honda Center · Anaheim, CA |
| 69 | Fri Mar 17 | vsJackets | W7-4 | 23-36-10 | 56 PTS | Honda Center · Anaheim, CA |
| 70 | Sun Mar 19 | vsCanucks | L1-2 | 23-37-10 | 56 PTS | Honda Center · Anaheim, CA |
| 71 | Tue Mar 21 | vsFlames | L1-5 | 23-38-10 | 56 PTS | Honda Center · Anaheim, CA |
| 72 | Thu Mar 23 | vsJets | L2-3 | 23-39-10 | 56 PTS | Honda Center · Anaheim, CA |
| 73 | Sat Mar 25 | vsBlues | L3-6 | 23-40-10 | 56 PTS | Honda Center · Anaheim, CA |
| 74 | Mon Mar 27 | vsAvalanche | L1-5 | 23-41-10 | 56 PTS | Honda Center · Anaheim, CA |
| 75 | Thu Mar 30 | atKraken | L1-4 | 23-42-10 | 56 PTS | Climate Pledge Arena · Seattle, WA |
| 76 | Sat Apr 1 | atOilers | L0-6 | 23-43-10 | 56 PTS | Rogers Place · Edmonton, AB |
| 77 | Sun Apr 2 | atFlames | L4-5 | 23-44-10 | 56 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 78 | Wed Apr 5 | vsOilers | L1-3 | 23-45-10 | 56 PTS | Honda Center · Anaheim, CA |
| 79 | Sat Apr 8 | atCoyotes | L4-5 (OT) | 23-45-11 | 57 PTS | Mullett Arena · Tempe, AZ |
| 80 | Sun Apr 9 | vsAvalanche | L4-5 (OT) | 23-45-12 | 58 PTS | Honda Center · Anaheim, CA |
| 81 | Tue Apr 11 | vsCanucks | L2-3 | 23-46-12 | 58 PTS | Honda Center · Anaheim, CA |
| 82 | Thu Apr 13 | vsKings | L3-5 | 23-47-12 | 58 PTS | Honda Center · Anaheim, CA |
