| 1 | Wed Oct 12 | vs Blackhawks | W5-2 | 1-0-0 | 2 PTS | Ball Arena · Denver, CO |
| 2 | Thu Oct 13 | atFlames | L3-5 | 1-1-0 | 2 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 3 | Mon Oct 17 | atWild | W6-3 | 2-1-0 | 4 PTS | Xcel Energy Center · St. Paul, MN |
| 4 | Wed Oct 19 | vsJets | L3-4 (OT) | 2-1-1 | 5 PTS | Ball Arena · Denver, CO |
| 5 | Fri Oct 21 | vsKraken | L2-3 | 2-2-1 | 5 PTS | Ball Arena · Denver, CO |
| 6 | Sat Oct 22 | atKnights | W3-2 | 3-2-1 | 7 PTS | T-Mobile Arena · Las Vegas, NV |
| 7 | Tue Oct 25 | atRangers | W3-2 (SO) | 4-2-1 | 9 PTS | Madison Square Garden · Manhattan, NY |
| 8 | Fri Oct 28 | atDevils | L0-1 | 4-3-1 | 9 PTS | Prudential Center · Newark, NJ |
| 9 | Sat Oct 29 | atIslanders | L4-5 | 4-4-1 | 9 PTS | UBS Arena · Elmont, NY |
| 10 | Fri Nov 4 | vsJackets | W6-3 | 5-4-1 | 11 PTS | Ball Arena · Denver, CO |
| 11 | Sat Nov 5 | atJackets | W5-1 | 6-4-1 | 13 PTS | Nationwide Arena · Columbus, OH |
| 12 | Thu Nov 10 | vsPredators | W5-3 | 7-4-1 | 15 PTS | Ball Arena · Denver, CO |
| 13 | Sat Nov 12 | vsHurricanes | W4-1 | 8-4-1 | 17 PTS | Ball Arena · Denver, CO |
| 14 | Mon Nov 14 | vsBlues | L2-3 | 8-5-1 | 17 PTS | Ball Arena · Denver, CO |
| 15 | Thu Nov 17 | atHurricanes | W3-2 (OT) | 9-5-1 | 19 PTS | PNC Arena · Raleigh, NC |
| 16 | Sat Nov 19 | atCapitals | W4-0 | 10-5-1 | 21 PTS | Capital One Arena · Washington, D.C. |
| 17 | Mon Nov 21 | atStars | W3-2 (SO) | 11-5-1 | 23 PTS | American Airlines Center · Dallas, TX |
| 18 | Wed Nov 23 | vsCanucks | L3-4 | 11-6-1 | 23 PTS | Ball Arena · Denver, CO |
| 19 | Sat Nov 26 | vsStars | W4-1 | 12-6-1 | 25 PTS | Ball Arena · Denver, CO |
| 20 | Tue Nov 29 | atJets | L0-5 | 12-7-1 | 25 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 21 | Thu Dec 1 | atSabres | W6-4 | 13-7-1 | 27 PTS | KeyBank Center · Buffalo, NY |
| 22 | Sat Dec 3 | atBruins | L1-5 | 13-8-1 | 27 PTS | TD Garden · Boston, MA |
| 23 | Mon Dec 5 | atFlyers | L3-5 | 13-9-1 | 27 PTS | Wells Fargo Center · Philadelphia, PA |
| 24 | Wed Dec 7 | vsBruins | L0-4 | 13-10-1 | 27 PTS | Ball Arena · Denver, CO |
| 25 | Fri Dec 9 | vsRangers | L1-2 (SO) | 13-10-2 | 28 PTS | Ball Arena · Denver, CO |
| 26 | Sun Dec 11 | atBlues | W3-2 (OT) | 14-10-2 | 30 PTS | Enterprise Center · St. Louis, MO |
| 27 | Tue Dec 13 | vsFlyers | W3-2 | 15-10-2 | 32 PTS | Ball Arena · Denver, CO |
| 28 | Thu Dec 15 | vsSabres | L2-4 | 15-11-2 | 32 PTS | Ball Arena · Denver, CO |
| 29 | Sat Dec 17 | vsPredators | W3-1 | 16-11-2 | 34 PTS | Ball Arena · Denver, CO |
| 30 | Mon Dec 19 | vsIslanders | W1-0 (SO) | 17-11-2 | 36 PTS | Ball Arena · Denver, CO |
| 31 | Wed Dec 21 | vsCanadiens | W2-1 (OT) | 18-11-2 | 38 PTS | Ball Arena · Denver, CO |
| 32 | Fri Dec 23 | atPredators | W3-2 (OT) | 19-11-2 | 40 PTS | Bridgestone Arena · Nashville, TN |
| 33 | Tue Dec 27 | atCoyotes | L3-6 | 19-12-2 | 40 PTS | Mullett Arena · Tempe, AZ |
| 34 | Thu Dec 29 | vsKings | L4-5 (SO) | 19-12-3 | 41 PTS | Ball Arena · Denver, CO |
| 35 | Sat Dec 31 | vsMaple Leafs | L2-6 | 19-13-3 | 41 PTS | Ball Arena · Denver, CO |
| 36 | Mon Jan 2 | vsKnights | L2-3 | 19-14-3 | 41 PTS | Ball Arena · Denver, CO |
| 37 | Thu Jan 5 | atCanucks | L2-4 | 19-15-3 | 41 PTS | Rogers Arena · Vancouver, British Columbia |
| 38 | Sat Jan 7 | atOilers | W3-2 (OT) | 20-15-3 | 43 PTS | Rogers Place · Edmonton, AB |
| 39 | Tue Jan 10 | vsPanthers | L4-5 | 20-16-3 | 43 PTS | Ball Arena · Denver, CO |
| 40 | Thu Jan 12 | atBlackhawks | L2-3 | 20-17-3 | 43 PTS | United Center · Chicago, IL |
| 41 | Sat Jan 14 | vsSenators | W7-0 | 21-17-3 | 45 PTS | Ball Arena · Denver, CO |
| 42 | Mon Jan 16 | vsRed Wings | W6-3 | 22-17-3 | 47 PTS | Ball Arena · Denver, CO |
| 43 | Wed Jan 18 | atFlames | W4-1 | 23-17-3 | 49 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 44 | Fri Jan 20 | atCanucks | W4-1 | 24-17-3 | 51 PTS | Rogers Arena · Vancouver, British Columbia |
| 45 | Sat Jan 21 | atKraken | W2-1 (SO) | 25-17-3 | 53 PTS | Climate Pledge Arena · Seattle, WA |
| 46 | Tue Jan 24 | vsCapitals | W3-2 | 26-17-3 | 55 PTS | Ball Arena · Denver, CO |
| 47 | Thu Jan 26 | vsDucks | L3-5 | 26-18-3 | 55 PTS | Ball Arena · Denver, CO |
| 48 | Sat Jan 28 | vsBlues | W4-2 | 27-18-3 | 57 PTS | Ball Arena · Denver, CO |
| 49 | Tue Feb 7 | atPenguins | L1-2 (OT) | 27-18-4 | 58 PTS | PPG Paints Arena · Pittsburgh, PA |
| 50 | Thu Feb 9 | atLightning | L0-5 | 27-19-4 | 58 PTS | AMALIE Arena · Tampa, FL |
| 51 | Sat Feb 11 | atPanthers | W5-3 | 28-19-4 | 60 PTS | Amerant Bank Arena · Sunrise, FL |
| 52 | Tue Feb 14 | vsLightning | L3-4 (SO) | 28-19-5 | 61 PTS | Ball Arena · Denver, CO |
| 53 | Wed Feb 15 | atWild | W3-2 | 29-19-5 | 63 PTS | Xcel Energy Center · St. Paul, MN |
| 54 | Sat Feb 18 | atBlues | W4-1 | 30-19-5 | 65 PTS | Enterprise Center · St. Louis, MO |
| 55 | Sun Feb 19 | vsOilers | W6-5 (OT) | 31-19-5 | 67 PTS | Ball Arena · Denver, CO |
| 56 | Fri Feb 24 | atJets | W5-1 | 32-19-5 | 69 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 57 | Sat Feb 25 | vsFlames | W4-1 | 33-19-5 | 71 PTS | Ball Arena · Denver, CO |
| 58 | Mon Feb 27 | vsKnights | W3-0 | 34-19-5 | 73 PTS | Ball Arena · Denver, CO |
| 59 | Wed Mar 1 | vsDevils | L5-7 | 34-20-5 | 73 PTS | Ball Arena · Denver, CO |
| 60 | Sat Mar 4 | atStars | L3-7 | 34-21-5 | 73 PTS | American Airlines Center · Dallas, TX |
| 61 | Sun Mar 5 | vsKraken | L2-3 (OT) | 34-21-6 | 74 PTS | Ball Arena · Denver, CO |
| 62 | Tue Mar 7 | vsSharks | W6-0 | 35-21-6 | 76 PTS | Ball Arena · Denver, CO |
| 63 | Thu Mar 9 | vsKings | L2-5 | 35-22-6 | 76 PTS | Ball Arena · Denver, CO |
| 64 | Sat Mar 11 | vsCoyotes | W3-2 (OT) | 36-22-6 | 78 PTS | Ball Arena · Denver, CO |
| 65 | Mon Mar 13 | atCanadiens | W8-4 | 37-22-6 | 80 PTS | Bell Centre · Montreal, QC |
| 66 | Wed Mar 15 | atMaple Leafs | W2-1 (SO) | 38-22-6 | 82 PTS | Scotiabank Arena · Toronto, ON |
| 67 | Thu Mar 16 | atSenators | W5-4 | 39-22-6 | 84 PTS | Canadian Tire Centre · Ottawa, ON |
| 68 | Sat Mar 18 | atRed Wings | W5-1 | 40-22-6 | 86 PTS | Little Caesars Arena · Detroit, MI |
| 69 | Mon Mar 20 | vsBlackhawks | W5-0 | 41-22-6 | 88 PTS | Ball Arena · Denver, CO |
| 70 | Wed Mar 22 | vsPenguins | L2-5 | 41-23-6 | 88 PTS | Ball Arena · Denver, CO |
| 71 | Fri Mar 24 | vsCoyotes | W3-1 | 42-23-6 | 90 PTS | Ball Arena · Denver, CO |
| 72 | Sun Mar 26 | atCoyotes | W4-3 (SO) | 43-23-6 | 92 PTS | Mullett Arena · Tempe, AZ |
| 73 | Mon Mar 27 | atDucks | W5-1 | 44-23-6 | 94 PTS | Honda Center · Anaheim, CA |
| 74 | Wed Mar 29 | vsWild | L2-4 | 44-24-6 | 94 PTS | Ball Arena · Denver, CO |
| 75 | Sat Apr 1 | vsStars | W5-2 | 45-24-6 | 96 PTS | Ball Arena · Denver, CO |
| 76 | Tue Apr 4 | atSharks | W4-3 (OT) | 46-24-6 | 98 PTS | SAP Center · San Jose, CA |
| 77 | Thu Apr 6 | atSharks | W6-2 | 47-24-6 | 100 PTS | SAP Center · San Jose, CA |
| 78 | Sat Apr 8 | atKings | W4-3 | 48-24-6 | 102 PTS | Crypto.com Arena · Los Angeles, CA |
| 79 | Sun Apr 9 | atDucks | W5-4 (OT) | 49-24-6 | 104 PTS | Honda Center · Anaheim, CA |
| 80 | Tue Apr 11 | vsOilers | L1-2 (OT) | 49-24-7 | 105 PTS | Ball Arena · Denver, CO |
| 81 | Thu Apr 13 | vsJets | W4-2 | 50-24-7 | 107 PTS | Ball Arena · Denver, CO |
| 82 | Fri Apr 14 | atPredators | W4-3 | 51-24-7 | 109 PTS | Bridgestone Arena · Nashville, TN |
| 1 | Tue Apr 18 | vsKraken | L1-3 | 0-1 | .000 | Ball Arena · Denver, CO |
| 2 | Thu Apr 20 | vsKraken | W3-2 | 1-1 | .500 | Ball Arena · Denver, CO |
| 3 | Sat Apr 22 | atKraken | W6-4 | 2-1 | .667 | Climate Pledge Arena · Seattle, WA |
| 4 | Mon Apr 24 | atKraken | L2-3 (OT) | 2-2 | .500 | Climate Pledge Arena · Seattle, WA |
| 5 | Wed Apr 26 | vsKraken | L2-3 | 2-3 | .400 | Ball Arena · Denver, CO |
| 6 | Fri Apr 28 | atKraken | W4-1 | 3-3 | .500 | Climate Pledge Arena · Seattle, WA |
| 7 | Sun Apr 30 | vsKraken | L1-2 | 3-4 | .429 | Ball Arena · Denver, CO |
