| 1 | Thu Oct 14 | vs Maple Leafs | W3-2 | 1-0-0 | 2 PTS | Canadian Tire Centre · Ottawa, ON |
| 2 | Sat Oct 16 | atMaple Leafs | L1-3 | 1-1-0 | 2 PTS | Scotiabank Arena · Toronto, ON |
| 3 | Sun Oct 17 | vsStars | W3-2 | 2-1-0 | 4 PTS | Canadian Tire Centre · Ottawa, ON |
| 4 | Thu Oct 21 | vsSharks | L1-2 | 2-2-0 | 4 PTS | Canadian Tire Centre · Ottawa, ON |
| 5 | Sat Oct 23 | vsRangers | L2-3 | 2-3-0 | 4 PTS | Canadian Tire Centre · Ottawa, ON |
| 6 | Mon Oct 25 | vsCapitals | L5-7 | 2-4-0 | 4 PTS | Canadian Tire Centre · Ottawa, ON |
| 7 | Fri Oct 29 | atStars | W4-1 | 3-4-0 | 6 PTS | American Airlines Center · Dallas, TX |
| 8 | Mon Nov 1 | atBlackhawks | L1-5 | 3-5-0 | 6 PTS | United Center · Chicago, IL |
| 9 | Tue Nov 2 | atWild | L4-5 (OT) | 3-5-1 | 7 PTS | Xcel Energy Center · St. Paul, MN |
| 10 | Thu Nov 4 | vsKnights | L1-5 | 3-6-1 | 7 PTS | Canadian Tire Centre · Ottawa, ON |
| 11 | Sat Nov 6 | vsLightning | L3-5 | 3-7-1 | 7 PTS | Canadian Tire Centre · Ottawa, ON |
| 12 | Tue Nov 9 | atBruins | L2-3 | 3-8-1 | 7 PTS | TD Garden · Boston, MA |
| 13 | Thu Nov 11 | vsKings | L0-2 | 3-9-1 | 7 PTS | Canadian Tire Centre · Ottawa, ON |
| 14 | Sat Nov 13 | vsPenguins | W6-3 | 4-9-1 | 9 PTS | Canadian Tire Centre · Ottawa, ON |
| 15 | Sun Nov 14 | vsFlames | L0-4 | 4-10-1 | 9 PTS | Canadian Tire Centre · Ottawa, ON |
| 16 | Mon Nov 22 | atAvalanche | L5-7 | 4-11-1 | 9 PTS | Ball Arena · Denver, CO |
| 17 | Wed Nov 24 | atSharks | L3-6 | 4-12-1 | 9 PTS | SAP Center · San Jose, CA |
| 18 | Fri Nov 26 | atDucks | L0-4 | 4-13-1 | 9 PTS | Honda Center · Anaheim, CA |
| 19 | Sat Nov 27 | atKings | L2-4 | 4-14-1 | 9 PTS | Crypto.com Arena · Los Angeles, CA |
| 20 | Wed Dec 1 | vsCanucks | L2-6 | 4-15-1 | 9 PTS | Canadian Tire Centre · Ottawa, ON |
| 21 | Thu Dec 2 | atHurricanes | W3-2 | 5-15-1 | 11 PTS | PNC Arena · Raleigh, NC |
| 22 | Sat Dec 4 | vsAvalanche | W6-5 (OT) | 6-15-1 | 13 PTS | Canadian Tire Centre · Ottawa, ON |
| 23 | Mon Dec 6 | atDevils | W3-2 (SO) | 7-15-1 | 15 PTS | Prudential Center · Newark, NJ |
| 24 | Tue Dec 7 | vsIslanders | L3-5 | 7-16-1 | 15 PTS | Canadian Tire Centre · Ottawa, ON |
| 25 | Sat Dec 11 | vsLightning | W4-0 | 8-16-1 | 17 PTS | Canadian Tire Centre · Ottawa, ON |
| 26 | Tue Dec 14 | atPanthers | W8-2 | 9-16-1 | 19 PTS | Amerant Bank Arena · Sunrise, FL |
| 27 | Thu Dec 16 | atLightning | L1-2 | 9-17-1 | 19 PTS | AMALIE Arena · Tampa, FL |
| 28 | Sat Dec 18 | atFlyers | L3-4 (OT) | 9-17-2 | 20 PTS | Wells Fargo Center · Philadelphia, PA |
| 29 | Sat Jan 1 | atMaple Leafs | L0-6 | 9-18-2 | 20 PTS | Scotiabank Arena · Toronto, ON |
| 30 | Thu Jan 13 | atFlames | W4-1 | 10-18-2 | 22 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 31 | Sat Jan 15 | atOilers | W6-4 | 11-18-2 | 24 PTS | Rogers Place · Edmonton, AB |
| 32 | Tue Jan 18 | vsSabres | L1-3 | 11-19-2 | 24 PTS | Canadian Tire Centre · Ottawa, ON |
| 33 | Thu Jan 20 | atPenguins | L4-6 | 11-20-2 | 24 PTS | PPG Paints Arena · Pittsburgh, PA |
| 34 | Sat Jan 22 | atCapitals | L2-3 (OT) | 11-20-3 | 25 PTS | Capital One Arena · Washington, D.C. |
| 35 | Sun Jan 23 | atJackets | W2-1 | 12-20-3 | 27 PTS | Nationwide Arena · Columbus, OH |
| 36 | Tue Jan 25 | vsSabres | W5-0 | 13-20-3 | 29 PTS | Canadian Tire Centre · Ottawa, ON |
| 37 | Thu Jan 27 | vsHurricanes | L2-3 (SO) | 13-20-4 | 30 PTS | Canadian Tire Centre · Ottawa, ON |
| 38 | Sat Jan 29 | vsDucks | L1-2 | 13-21-4 | 30 PTS | Canadian Tire Centre · Ottawa, ON |
| 39 | Mon Jan 31 | vsOilers | W3-2 (OT) | 14-21-4 | 32 PTS | Canadian Tire Centre · Ottawa, ON |
| 40 | Tue Feb 1 | atIslanders | L1-4 | 14-22-4 | 32 PTS | UBS Arena · Elmont, NY |
| 41 | Mon Feb 7 | vsDevils | W4-1 | 15-22-4 | 34 PTS | Canadian Tire Centre · Ottawa, ON |
| 42 | Tue Feb 8 | vsHurricanes | W4-3 | 16-22-4 | 36 PTS | Canadian Tire Centre · Ottawa, ON |
| 43 | Thu Feb 10 | vsPenguins | L0-2 | 16-23-4 | 36 PTS | Canadian Tire Centre · Ottawa, ON |
| 44 | Sat Feb 12 | vsBruins | L0-2 | 16-24-4 | 36 PTS | Canadian Tire Centre · Ottawa, ON |
| 45 | Sun Feb 13 | atCapitals | W4-1 | 17-24-4 | 38 PTS | Capital One Arena · Washington, D.C. |
| 46 | Tue Feb 15 | vsBlues | L2-5 | 17-25-4 | 38 PTS | Canadian Tire Centre · Ottawa, ON |
| 47 | Thu Feb 17 | atSabres | W3-1 | 18-25-4 | 40 PTS | KeyBank Center · Buffalo, NY |
| 48 | Sat Feb 19 | vsBruins | L2-3 (OT) | 18-25-5 | 41 PTS | Canadian Tire Centre · Ottawa, ON |
| 49 | Sun Feb 20 | vsRangers | L1-2 | 18-26-5 | 41 PTS | Canadian Tire Centre · Ottawa, ON |
| 50 | Tue Feb 22 | vsWild | W4-3 | 19-26-5 | 43 PTS | Canadian Tire Centre · Ottawa, ON |
| 51 | Sat Feb 26 | vsCanadiens | L1-2 | 19-27-5 | 43 PTS | Canadian Tire Centre · Ottawa, ON |
| 52 | Tue Mar 1 | atLightning | L2-5 | 19-28-5 | 43 PTS | AMALIE Arena · Tampa, FL |
| 53 | Thu Mar 3 | atPanthers | L0-3 | 19-29-5 | 43 PTS | Amerant Bank Arena · Sunrise, FL |
| 54 | Sat Mar 5 | atCoyotes | L5-8 | 19-30-5 | 43 PTS | Mullett Arena · Tempe, AZ |
| 55 | Sun Mar 6 | atKnights | L1-2 | 19-31-5 | 43 PTS | T-Mobile Arena · Las Vegas, NV |
| 56 | Tue Mar 8 | atBlues | W4-1 | 20-31-5 | 45 PTS | Enterprise Center · St. Louis, MO |
| 57 | Thu Mar 10 | vsKraken | W4-3 (OT) | 21-31-5 | 47 PTS | Canadian Tire Centre · Ottawa, ON |
| 58 | Sat Mar 12 | vsBlackhawks | L3-6 | 21-32-5 | 47 PTS | Canadian Tire Centre · Ottawa, ON |
| 59 | Mon Mar 14 | vsCoyotes | L3-5 | 21-33-5 | 47 PTS | Canadian Tire Centre · Ottawa, ON |
| 60 | Wed Mar 16 | vsJackets | L1-4 | 21-34-5 | 47 PTS | Canadian Tire Centre · Ottawa, ON |
| 61 | Fri Mar 18 | vsFlyers | W3-1 | 22-34-5 | 49 PTS | Canadian Tire Centre · Ottawa, ON |
| 62 | Sat Mar 19 | atCanadiens | L1-5 | 22-35-5 | 49 PTS | Bell Centre · Montreal, QC |
| 63 | Tue Mar 22 | atIslanders | L0-3 | 22-36-5 | 49 PTS | UBS Arena · Elmont, NY |
| 64 | Thu Mar 24 | atJets | W5-2 | 23-36-5 | 51 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 65 | Sat Mar 26 | vsPanthers | L3-4 (SO) | 23-36-6 | 52 PTS | Canadian Tire Centre · Ottawa, ON |
| 66 | Tue Mar 29 | atPredators | L1-4 | 23-37-6 | 52 PTS | Bridgestone Arena · Nashville, TN |
| 67 | Fri Apr 1 | atRed Wings | W5-2 | 24-37-6 | 54 PTS | Little Caesars Arena · Detroit, MI |
| 68 | Sun Apr 3 | vsRed Wings | W5-2 | 25-37-6 | 56 PTS | Canadian Tire Centre · Ottawa, ON |
| 69 | Tue Apr 5 | atCanadiens | W6-3 | 26-37-6 | 58 PTS | Bell Centre · Montreal, QC |
| 70 | Thu Apr 7 | vsPredators | L2-3 | 26-38-6 | 58 PTS | Canadian Tire Centre · Ottawa, ON |
| 71 | Sat Apr 9 | atRangers | L1-5 | 26-39-6 | 58 PTS | Madison Square Garden · Manhattan, NY |
| 72 | Sun Apr 10 | vsJets | L3-4 | 26-40-6 | 58 PTS | Canadian Tire Centre · Ottawa, ON |
| 73 | Tue Apr 12 | atRed Wings | W4-1 | 27-40-6 | 60 PTS | Little Caesars Arena · Detroit, MI |
| 74 | Thu Apr 14 | atBruins | W3-2 | 28-40-6 | 62 PTS | TD Garden · Boston, MA |
| 75 | Sat Apr 16 | vsMaple Leafs | L4-5 (OT) | 28-40-7 | 63 PTS | Canadian Tire Centre · Ottawa, ON |
| 76 | Mon Apr 18 | atKraken | L2-4 | 28-41-7 | 63 PTS | Climate Pledge Arena · Seattle, WA |
| 77 | Tue Apr 19 | atCanucks | W4-3 (SO) | 29-41-7 | 65 PTS | Rogers Arena · Vancouver, British Columbia |
| 78 | Fri Apr 22 | atJackets | W2-1 (SO) | 30-41-7 | 67 PTS | Nationwide Arena · Columbus, OH |
| 79 | Sat Apr 23 | vsCanadiens | W6-4 | 31-41-7 | 69 PTS | Canadian Tire Centre · Ottawa, ON |
| 80 | Tue Apr 26 | vsDevils | W5-4 (OT) | 32-41-7 | 71 PTS | Canadian Tire Centre · Ottawa, ON |
| 81 | Thu Apr 28 | vsPanthers | L0-4 | 32-42-7 | 71 PTS | Canadian Tire Centre · Ottawa, ON |
| 82 | Fri Apr 29 | atFlyers | W4-2 | 33-42-7 | 73 PTS | Wells Fargo Center · Philadelphia, PA |
