| 1 | Wed Oct 11 | at Hurricanes | L3-5 | 0-1-0 | 0 PTS | PNC Arena · Raleigh, NC |
| 2 | Sat Oct 14 | vsFlyers | W5-2 | 1-1-0 | 2 PTS | Canadian Tire Centre · Ottawa, ON |
| 3 | Sun Oct 15 | vsLightning | W5-2 | 2-1-0 | 4 PTS | Canadian Tire Centre · Ottawa, ON |
| 4 | Wed Oct 18 | vsCapitals | W6-1 | 3-1-0 | 6 PTS | Canadian Tire Centre · Ottawa, ON |
| 5 | Sat Oct 21 | vsRed Wings | L2-5 | 3-2-0 | 6 PTS | Canadian Tire Centre · Ottawa, ON |
| 6 | Tue Oct 24 | vsSabres | L4-6 | 3-3-0 | 6 PTS | Canadian Tire Centre · Ottawa, ON |
| 7 | Thu Oct 26 | atIslanders | L2-3 | 3-4-0 | 6 PTS | UBS Arena · Elmont, NY |
| 8 | Sat Oct 28 | atPenguins | W5-2 | 4-4-0 | 8 PTS | PPG Paints Arena · Pittsburgh, PA |
| 9 | Thu Nov 2 | vsKings | L2-3 | 4-5-0 | 8 PTS | Canadian Tire Centre · Ottawa, ON |
| 10 | Sat Nov 4 | vsLightning | L4-6 | 4-6-0 | 8 PTS | Canadian Tire Centre · Ottawa, ON |
| 11 | Wed Nov 8 | atMaple Leafs | W6-3 | 5-6-0 | 10 PTS | Scotiabank Arena · Toronto, ON |
| 12 | Thu Nov 9 | vsCanucks | L2-5 | 5-7-0 | 10 PTS | Canadian Tire Centre · Ottawa, ON |
| 13 | Sat Nov 11 | vsFlames | W4-1 | 6-7-0 | 12 PTS | Canadian Tire Centre · Ottawa, ON |
| 14 | Thu Nov 16 | vsRed Wings | W5-4 (OT) | 7-7-0 | 14 PTS | Canadian Tire Centre · Ottawa, ON |
| 15 | Sat Nov 18 | vsWild | W2-1 (SO) | 8-7-0 | 16 PTS | Canadian Tire Centre · Ottawa, ON |
| 16 | Fri Nov 24 | vsIslanders | L3-5 | 8-8-0 | 16 PTS | Canadian Tire Centre · Ottawa, ON |
| 17 | Mon Nov 27 | vsPanthers | L0-5 | 8-9-0 | 16 PTS | Canadian Tire Centre · Ottawa, ON |
| 18 | Fri Dec 1 | atJackets | L2-4 | 8-10-0 | 16 PTS | Nationwide Arena · Columbus, OH |
| 19 | Sat Dec 2 | vsKraken | W2-0 | 9-10-0 | 18 PTS | Canadian Tire Centre · Ottawa, ON |
| 20 | Tue Dec 5 | vsRangers | W6-2 | 10-10-0 | 20 PTS | Canadian Tire Centre · Ottawa, ON |
| 21 | Thu Dec 7 | vsMaple Leafs | L3-4 | 10-11-0 | 20 PTS | Canadian Tire Centre · Ottawa, ON |
| 22 | Sat Dec 9 | atRed Wings | W5-1 | 11-11-0 | 22 PTS | Little Caesars Arena · Detroit, MI |
| 23 | Tue Dec 12 | vsHurricanes | L1-4 | 11-12-0 | 22 PTS | Canadian Tire Centre · Ottawa, ON |
| 24 | Thu Dec 14 | atBlues | L2-4 | 11-13-0 | 22 PTS | Enterprise Center · St. Louis, MO |
| 25 | Fri Dec 15 | atStars | L4-5 | 11-14-0 | 22 PTS | American Airlines Center · Dallas, TX |
| 26 | Sun Dec 17 | atKnights | L3-6 | 11-15-0 | 22 PTS | T-Mobile Arena · Las Vegas, NV |
| 27 | Tue Dec 19 | atCoyotes | L3-4 | 11-16-0 | 22 PTS | Mullett Arena · Tempe, AZ |
| 28 | Thu Dec 21 | atAvalanche | L4-6 | 11-17-0 | 22 PTS | Ball Arena · Denver, CO |
| 29 | Sat Dec 23 | vsPenguins | W5-4 (OT) | 12-17-0 | 24 PTS | Canadian Tire Centre · Ottawa, ON |
| 30 | Wed Dec 27 | atMaple Leafs | W4-2 | 13-17-0 | 26 PTS | Scotiabank Arena · Toronto, ON |
| 31 | Fri Dec 29 | vsDevils | L2-6 | 13-18-0 | 26 PTS | Canadian Tire Centre · Ottawa, ON |
| 32 | Sun Dec 31 | vsSabres | W5-1 | 14-18-0 | 28 PTS | Canadian Tire Centre · Ottawa, ON |
| 33 | Tue Jan 2 | atCanucks | L3-6 | 14-19-0 | 28 PTS | Rogers Arena · Vancouver, British Columbia |
| 34 | Thu Jan 4 | atKraken | L1-4 | 14-20-0 | 28 PTS | Climate Pledge Arena · Seattle, WA |
| 35 | Sat Jan 6 | atOilers | L1-3 | 14-21-0 | 28 PTS | Rogers Place · Edmonton, AB |
| 36 | Tue Jan 9 | atFlames | L3-6 | 14-22-0 | 28 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 37 | Thu Jan 11 | atSabres | L3-5 | 14-23-0 | 28 PTS | KeyBank Center · Buffalo, NY |
| 38 | Sat Jan 13 | vsSharks | W5-4 | 15-23-0 | 30 PTS | Canadian Tire Centre · Ottawa, ON |
| 39 | Tue Jan 16 | vsAvalanche | L4-7 | 15-24-0 | 30 PTS | Canadian Tire Centre · Ottawa, ON |
| 40 | Thu Jan 18 | vsCanadiens | W6-2 | 16-24-0 | 32 PTS | Canadian Tire Centre · Ottawa, ON |
| 41 | Sat Jan 20 | vsJets | L1-2 (OT) | 16-24-1 | 33 PTS | Canadian Tire Centre · Ottawa, ON |
| 42 | Sun Jan 21 | atFlyers | W5-3 | 17-24-1 | 35 PTS | Wells Fargo Center · Philadelphia, PA |
| 43 | Tue Jan 23 | atCanadiens | W4-1 | 18-24-1 | 37 PTS | Bell Centre · Montreal, QC |
| 44 | Thu Jan 25 | vsBruins | L2-3 (OT) | 18-24-2 | 38 PTS | Canadian Tire Centre · Ottawa, ON |
| 45 | Sat Jan 27 | vsRangers | L2-7 | 18-25-2 | 38 PTS | Canadian Tire Centre · Ottawa, ON |
| 46 | Mon Jan 29 | vsPredators | W4-3 (OT) | 19-25-2 | 40 PTS | Canadian Tire Centre · Ottawa, ON |
| 47 | Wed Jan 31 | atRed Wings | W3-2 (OT) | 20-25-2 | 42 PTS | Little Caesars Arena · Detroit, MI |
| 48 | Sat Feb 10 | vsMaple Leafs | W5-3 | 21-25-2 | 44 PTS | Canadian Tire Centre · Ottawa, ON |
| 49 | Tue Feb 13 | vsJackets | W6-3 | 22-25-2 | 46 PTS | Canadian Tire Centre · Ottawa, ON |
| 50 | Thu Feb 15 | vsDucks | L1-5 | 22-26-2 | 46 PTS | Canadian Tire Centre · Ottawa, ON |
| 51 | Sat Feb 17 | atBlackhawks | L2-3 | 22-27-2 | 46 PTS | United Center · Chicago, IL |
| 52 | Mon Feb 19 | atLightning | W4-2 | 23-27-2 | 48 PTS | AMALIE Arena · Tampa, FL |
| 53 | Tue Feb 20 | atPanthers | L2-3 (OT) | 23-27-3 | 49 PTS | Amerant Bank Arena · Sunrise, FL |
| 54 | Thu Feb 22 | vsStars | W4-1 | 24-27-3 | 51 PTS | Canadian Tire Centre · Ottawa, ON |
| 55 | Sat Feb 24 | vsKnights | W4-3 (SO) | 25-27-3 | 53 PTS | Canadian Tire Centre · Ottawa, ON |
| 56 | Mon Feb 26 | atCapitals | L3-6 | 25-28-3 | 53 PTS | Capital One Arena · Washington, D.C. |
| 57 | Tue Feb 27 | atPredators | L1-4 | 25-29-3 | 53 PTS | Bridgestone Arena · Nashville, TN |
| 58 | Fri Mar 1 | vsCoyotes | L3-5 | 25-30-3 | 53 PTS | Canadian Tire Centre · Ottawa, ON |
| 59 | Sat Mar 2 | atFlyers | L2-4 | 25-31-3 | 53 PTS | Wells Fargo Center · Philadelphia, PA |
| 60 | Wed Mar 6 | atDucks | L1-2 | 25-32-3 | 53 PTS | Honda Center · Anaheim, CA |
| 61 | Thu Mar 7 | atKings | L3-4 (OT) | 25-32-4 | 54 PTS | Crypto.com Arena · Los Angeles, CA |
| 62 | Sat Mar 9 | atSharks | L1-2 | 25-33-4 | 54 PTS | SAP Center · San Jose, CA |
| 63 | Tue Mar 12 | vsPenguins | W2-1 (OT) | 26-33-4 | 56 PTS | Canadian Tire Centre · Ottawa, ON |
| 64 | Thu Mar 14 | atJackets | W3-2 (SO) | 27-33-4 | 58 PTS | Nationwide Arena · Columbus, OH |
| 65 | Sat Mar 16 | atIslanders | W4-3 (OT) | 28-33-4 | 60 PTS | UBS Arena · Elmont, NY |
| 66 | Sun Mar 17 | vsHurricanes | L2-7 | 28-34-4 | 60 PTS | Canadian Tire Centre · Ottawa, ON |
| 67 | Tue Mar 19 | atBruins | L2-6 | 28-35-4 | 60 PTS | TD Garden · Boston, MA |
| 68 | Thu Mar 21 | vsBlues | L2-5 | 28-36-4 | 60 PTS | Canadian Tire Centre · Ottawa, ON |
| 69 | Sat Mar 23 | atDevils | W5-2 | 29-36-4 | 62 PTS | Prudential Center · Newark, NJ |
| 70 | Sun Mar 24 | vsOilers | W5-3 | 30-36-4 | 64 PTS | Canadian Tire Centre · Ottawa, ON |
| 71 | Wed Mar 27 | atSabres | W6-2 | 31-36-4 | 66 PTS | KeyBank Center · Buffalo, NY |
| 72 | Thu Mar 28 | vsBlackhawks | W2-0 | 32-36-4 | 68 PTS | Canadian Tire Centre · Ottawa, ON |
| 73 | Sat Mar 30 | atJets | W3-2 | 33-36-4 | 70 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 74 | Tue Apr 2 | atWild | L2-3 | 33-37-4 | 70 PTS | Xcel Energy Center · St. Paul, MN |
| 75 | Thu Apr 4 | vsPanthers | L0-6 | 33-38-4 | 70 PTS | Canadian Tire Centre · Ottawa, ON |
| 76 | Sat Apr 6 | vsDevils | L3-4 | 33-39-4 | 70 PTS | Canadian Tire Centre · Ottawa, ON |
| 77 | Sun Apr 7 | atCapitals | W3-2 (OT) | 34-39-4 | 72 PTS | Capital One Arena · Washington, D.C. |
| 78 | Tue Apr 9 | atPanthers | L0-2 | 34-40-4 | 72 PTS | Amerant Bank Arena · Sunrise, FL |
| 79 | Thu Apr 11 | atLightning | W3-2 (SO) | 35-40-4 | 74 PTS | AMALIE Arena · Tampa, FL |
| 80 | Sat Apr 13 | vsCanadiens | W5-4 (SO) | 36-40-4 | 76 PTS | Canadian Tire Centre · Ottawa, ON |
| 81 | Mon Apr 15 | atRangers | L0-4 | 36-41-4 | 76 PTS | Madison Square Garden · Manhattan, NY |
| 82 | Tue Apr 16 | atBruins | W3-1 | 37-41-4 | 78 PTS | TD Garden · Boston, MA |
