| 1 | Thu Oct 13 | at Sabres | L1-4 | 0-1-0 | 0 PTS | KeyBank Center · Buffalo, NY |
| 2 | Sat Oct 15 | atMaple Leafs | L2-3 | 0-2-0 | 0 PTS | Scotiabank Arena · Toronto, ON |
| 3 | Tue Oct 18 | vsBruins | W7-5 | 1-2-0 | 2 PTS | Canadian Tire Centre · Ottawa, ON |
| 4 | Thu Oct 20 | vsCapitals | W5-2 | 2-2-0 | 4 PTS | Canadian Tire Centre · Ottawa, ON |
| 5 | Sat Oct 22 | vsCoyotes | W6-2 | 3-2-0 | 6 PTS | Canadian Tire Centre · Ottawa, ON |
| 6 | Mon Oct 24 | vsStars | W4-2 | 4-2-0 | 8 PTS | Canadian Tire Centre · Ottawa, ON |
| 7 | Thu Oct 27 | vsWild | L2-4 | 4-3-0 | 8 PTS | Canadian Tire Centre · Ottawa, ON |
| 8 | Sat Oct 29 | atPanthers | L3-5 | 4-4-0 | 8 PTS | Amerant Bank Arena · Sunrise, FL |
| 9 | Tue Nov 1 | atLightning | L3-4 | 4-5-0 | 8 PTS | AMALIE Arena · Tampa, FL |
| 10 | Thu Nov 3 | vsKnights | L4-5 | 4-6-0 | 8 PTS | Canadian Tire Centre · Ottawa, ON |
| 11 | Sat Nov 5 | vsFlyers | L1-2 | 4-7-0 | 8 PTS | Canadian Tire Centre · Ottawa, ON |
| 12 | Tue Nov 8 | vsCanucks | L4-6 | 4-8-0 | 8 PTS | Canadian Tire Centre · Ottawa, ON |
| 13 | Thu Nov 10 | atDevils | L3-4 (OT) | 4-8-1 | 9 PTS | Prudential Center · Newark, NJ |
| 14 | Sat Nov 12 | atFlyers | W4-1 | 5-8-1 | 11 PTS | Wells Fargo Center · Philadelphia, PA |
| 15 | Mon Nov 14 | vsIslanders | L2-4 | 5-9-1 | 11 PTS | Canadian Tire Centre · Ottawa, ON |
| 16 | Wed Nov 16 | vsSabres | W4-1 | 6-9-1 | 13 PTS | Canadian Tire Centre · Ottawa, ON |
| 17 | Sat Nov 19 | vsDevils | L1-5 | 6-10-1 | 13 PTS | Canadian Tire Centre · Ottawa, ON |
| 18 | Mon Nov 21 | atSharks | L1-5 | 6-11-1 | 13 PTS | SAP Center · San Jose, CA |
| 19 | Wed Nov 23 | atKnights | L1-4 | 6-12-1 | 13 PTS | T-Mobile Arena · Las Vegas, NV |
| 20 | Fri Nov 25 | atDucks | W5-1 | 7-12-1 | 15 PTS | Honda Center · Anaheim, CA |
| 21 | Sun Nov 27 | atKings | W3-2 (OT) | 8-12-1 | 17 PTS | Crypto.com Arena · Los Angeles, CA |
| 22 | Wed Nov 30 | vsRangers | L1-3 | 8-13-1 | 17 PTS | Canadian Tire Centre · Ottawa, ON |
| 23 | Fri Dec 2 | atRangers | W3-2 (OT) | 9-13-1 | 19 PTS | Madison Square Garden · Manhattan, NY |
| 24 | Sat Dec 3 | vsSharks | W5-2 | 10-13-1 | 21 PTS | Canadian Tire Centre · Ottawa, ON |
| 25 | Tue Dec 6 | vsKings | L2-5 | 10-14-1 | 21 PTS | Canadian Tire Centre · Ottawa, ON |
| 26 | Thu Dec 8 | atStars | L3-4 (OT) | 10-14-2 | 22 PTS | American Airlines Center · Dallas, TX |
| 27 | Sat Dec 10 | atPredators | W3-2 | 11-14-2 | 24 PTS | Bridgestone Arena · Nashville, TN |
| 28 | Mon Dec 12 | vsDucks | W3-0 | 12-14-2 | 26 PTS | Canadian Tire Centre · Ottawa, ON |
| 29 | Wed Dec 14 | vsCanadiens | W3-2 | 13-14-2 | 28 PTS | Canadian Tire Centre · Ottawa, ON |
| 30 | Sat Dec 17 | atRed Wings | W6-3 | 14-14-2 | 30 PTS | Little Caesars Arena · Detroit, MI |
| 31 | Sun Dec 18 | atWild | L2-4 | 14-15-2 | 30 PTS | Xcel Energy Center · St. Paul, MN |
| 32 | Tue Dec 20 | atJets | L1-5 | 14-16-2 | 30 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 33 | Thu Dec 22 | vsCapitals | L2-3 (OT) | 14-16-3 | 31 PTS | Canadian Tire Centre · Ottawa, ON |
| 34 | Tue Dec 27 | vsBruins | W3-2 (SO) | 15-16-3 | 33 PTS | Canadian Tire Centre · Ottawa, ON |
| 35 | Thu Dec 29 | atCapitals | W4-3 (OT) | 16-16-3 | 35 PTS | Capital One Arena · Washington, D.C. |
| 36 | Sat Dec 31 | atRed Wings | L2-4 | 16-17-3 | 35 PTS | Little Caesars Arena · Detroit, MI |
| 37 | Sun Jan 1 | vsSabres | W3-1 | 17-17-3 | 37 PTS | Canadian Tire Centre · Ottawa, ON |
| 38 | Tue Jan 3 | vsJackets | W4-0 | 18-17-3 | 39 PTS | Canadian Tire Centre · Ottawa, ON |
| 39 | Sat Jan 7 | vsKraken | L4-8 | 18-18-3 | 39 PTS | Canadian Tire Centre · Ottawa, ON |
| 40 | Mon Jan 9 | vsPredators | L0-3 | 18-19-3 | 39 PTS | Canadian Tire Centre · Ottawa, ON |
| 41 | Thu Jan 12 | atCoyotes | W5-3 | 19-19-3 | 41 PTS | Mullett Arena · Tempe, AZ |
| 42 | Sat Jan 14 | atAvalanche | L0-7 | 19-20-3 | 41 PTS | Ball Arena · Denver, CO |
| 43 | Mon Jan 16 | atBlues | L1-2 | 19-21-3 | 41 PTS | Enterprise Center · St. Louis, MO |
| 44 | Wed Jan 18 | vsPenguins | W5-4 (OT) | 20-21-3 | 43 PTS | Canadian Tire Centre · Ottawa, ON |
| 45 | Fri Jan 20 | atPenguins | L1-4 | 20-22-3 | 43 PTS | PPG Paints Arena · Pittsburgh, PA |
| 46 | Sat Jan 21 | vsJets | L1-5 | 20-23-3 | 43 PTS | Canadian Tire Centre · Ottawa, ON |
| 47 | Wed Jan 25 | vsIslanders | W2-1 | 21-23-3 | 45 PTS | Canadian Tire Centre · Ottawa, ON |
| 48 | Fri Jan 27 | atMaple Leafs | W6-2 | 22-23-3 | 47 PTS | Scotiabank Arena · Toronto, ON |
| 49 | Sat Jan 28 | vsCanadiens | W5-0 | 23-23-3 | 49 PTS | Canadian Tire Centre · Ottawa, ON |
| 50 | Tue Jan 31 | atCanadiens | W5-4 | 24-23-3 | 51 PTS | Bell Centre · Montreal, QC |
| 51 | Sat Feb 11 | vsOilers | L3-6 | 24-24-3 | 51 PTS | Canadian Tire Centre · Ottawa, ON |
| 52 | Mon Feb 13 | vsFlames | W4-3 (OT) | 25-24-3 | 53 PTS | Canadian Tire Centre · Ottawa, ON |
| 53 | Tue Feb 14 | atIslanders | W3-2 (SO) | 26-24-3 | 55 PTS | UBS Arena · Elmont, NY |
| 54 | Fri Feb 17 | vsBlackhawks | L3-4 (OT) | 26-24-4 | 56 PTS | Canadian Tire Centre · Ottawa, ON |
| 55 | Sun Feb 19 | vsBlues | W7-2 | 27-24-4 | 58 PTS | Canadian Tire Centre · Ottawa, ON |
| 56 | Mon Feb 20 | atBruins | L1-3 | 27-25-4 | 58 PTS | TD Garden · Boston, MA |
| 57 | Fri Feb 24 | atHurricanes | L0-4 | 27-26-4 | 58 PTS | PNC Arena · Raleigh, NC |
| 58 | Sat Feb 25 | atCanadiens | W5-2 | 28-26-4 | 60 PTS | Bell Centre · Montreal, QC |
| 59 | Mon Feb 27 | vsRed Wings | W6-2 | 29-26-4 | 62 PTS | Canadian Tire Centre · Ottawa, ON |
| 60 | Tue Feb 28 | vsRed Wings | W6-1 | 30-26-4 | 64 PTS | Canadian Tire Centre · Ottawa, ON |
| 61 | Thu Mar 2 | atRangers | W5-3 | 31-26-4 | 66 PTS | Madison Square Garden · Manhattan, NY |
| 62 | Sat Mar 4 | vsJackets | W5-2 | 32-26-4 | 68 PTS | Canadian Tire Centre · Ottawa, ON |
| 63 | Mon Mar 6 | atBlackhawks | L0-5 | 32-27-4 | 68 PTS | United Center · Chicago, IL |
| 64 | Thu Mar 9 | atKraken | W5-4 | 33-27-4 | 70 PTS | Climate Pledge Arena · Seattle, WA |
| 65 | Sat Mar 11 | atCanucks | L2-5 | 33-28-4 | 70 PTS | Rogers Arena · Vancouver, British Columbia |
| 66 | Sun Mar 12 | atFlames | L1-5 | 33-29-4 | 70 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 67 | Tue Mar 14 | atOilers | L3-6 | 33-30-4 | 70 PTS | Rogers Place · Edmonton, AB |
| 68 | Thu Mar 16 | vsAvalanche | L4-5 | 33-31-4 | 70 PTS | Canadian Tire Centre · Ottawa, ON |
| 69 | Sat Mar 18 | vsMaple Leafs | L4-5 (SO) | 33-31-5 | 71 PTS | Canadian Tire Centre · Ottawa, ON |
| 70 | Mon Mar 20 | atPenguins | W2-1 | 34-31-5 | 73 PTS | PPG Paints Arena · Pittsburgh, PA |
| 71 | Tue Mar 21 | atBruins | L1-2 | 34-32-5 | 73 PTS | TD Garden · Boston, MA |
| 72 | Thu Mar 23 | vsLightning | W7-2 | 35-32-5 | 75 PTS | Canadian Tire Centre · Ottawa, ON |
| 73 | Sat Mar 25 | atDevils | L3-5 | 35-33-5 | 75 PTS | Prudential Center · Newark, NJ |
| 74 | Mon Mar 27 | vsPanthers | W5-2 | 36-33-5 | 77 PTS | Canadian Tire Centre · Ottawa, ON |
| 75 | Thu Mar 30 | vsFlyers | W5-4 (OT) | 37-33-5 | 79 PTS | Canadian Tire Centre · Ottawa, ON |
| 76 | Sat Apr 1 | vsMaple Leafs | L0-3 | 37-34-5 | 79 PTS | Canadian Tire Centre · Ottawa, ON |
| 77 | Sun Apr 2 | atJackets | L3-4 (OT) | 37-34-6 | 80 PTS | Nationwide Arena · Columbus, OH |
| 78 | Tue Apr 4 | atHurricanes | L2-3 (OT) | 37-34-7 | 81 PTS | PNC Arena · Raleigh, NC |
| 79 | Thu Apr 6 | atPanthers | L2-7 | 37-35-7 | 81 PTS | Amerant Bank Arena · Sunrise, FL |
| 80 | Sat Apr 8 | vsLightning | W7-4 | 38-35-7 | 83 PTS | Canadian Tire Centre · Ottawa, ON |
| 81 | Mon Apr 10 | vsHurricanes | W3-2 | 39-35-7 | 85 PTS | Canadian Tire Centre · Ottawa, ON |
| 82 | Thu Apr 13 | atSabres | L3-4 (OT) | 39-35-8 | 86 PTS | KeyBank Center · Buffalo, NY |
