| 1 | Tue Oct 12 | vs Kraken | W4-3 | 1-0-0 | 2 PTS | T-Mobile Arena · Las Vegas, NV |
| 2 | Thu Oct 14 | atKings | L2-6 | 1-1-0 | 2 PTS | Crypto.com Arena · Los Angeles, CA |
| 3 | Wed Oct 20 | vsBlues | L1-3 | 1-2-0 | 2 PTS | T-Mobile Arena · Las Vegas, NV |
| 4 | Fri Oct 22 | vsOilers | L3-5 | 1-3-0 | 2 PTS | T-Mobile Arena · Las Vegas, NV |
| 5 | Sun Oct 24 | vsIslanders | L0-2 | 1-4-0 | 2 PTS | T-Mobile Arena · Las Vegas, NV |
| 6 | Tue Oct 26 | atAvalanche | W3-1 | 2-4-0 | 4 PTS | Ball Arena · Denver, CO |
| 7 | Wed Oct 27 | atStars | W3-2 (OT) | 3-4-0 | 6 PTS | American Airlines Center · Dallas, TX |
| 8 | Fri Oct 29 | vsDucks | W5-4 (SO) | 4-4-0 | 8 PTS | T-Mobile Arena · Las Vegas, NV |
| 9 | Tue Nov 2 | atMaple Leafs | L0-4 | 4-5-0 | 8 PTS | Scotiabank Arena · Toronto, ON |
| 10 | Thu Nov 4 | atSenators | W5-1 | 5-5-0 | 10 PTS | Canadian Tire Centre · Ottawa, ON |
| 11 | Sat Nov 6 | atCanadiens | W5-2 | 6-5-0 | 12 PTS | Bell Centre · Montreal, QC |
| 12 | Sun Nov 7 | atRed Wings | L2-5 | 6-6-0 | 12 PTS | Little Caesars Arena · Detroit, MI |
| 13 | Tue Nov 9 | vsKraken | W4-2 | 7-6-0 | 14 PTS | T-Mobile Arena · Las Vegas, NV |
| 14 | Thu Nov 11 | vsWild | W3-2 | 8-6-0 | 16 PTS | T-Mobile Arena · Las Vegas, NV |
| 15 | Sat Nov 13 | vsCanucks | W7-4 | 9-6-0 | 18 PTS | T-Mobile Arena · Las Vegas, NV |
| 16 | Tue Nov 16 | vsHurricanes | L2-4 | 9-7-0 | 18 PTS | T-Mobile Arena · Las Vegas, NV |
| 17 | Thu Nov 18 | vsRed Wings | W5-2 | 10-7-0 | 20 PTS | T-Mobile Arena · Las Vegas, NV |
| 18 | Sat Nov 20 | vsJackets | W3-2 | 11-7-0 | 22 PTS | T-Mobile Arena · Las Vegas, NV |
| 19 | Mon Nov 22 | atBlues | L2-5 | 11-8-0 | 22 PTS | Enterprise Center · St. Louis, MO |
| 20 | Wed Nov 24 | atPredators | W5-2 | 12-8-0 | 24 PTS | Bridgestone Arena · Nashville, TN |
| 21 | Sat Nov 27 | vsOilers | L2-3 | 12-9-0 | 24 PTS | T-Mobile Arena · Las Vegas, NV |
| 22 | Wed Dec 1 | atDucks | L5-6 | 12-10-0 | 24 PTS | Honda Center · Anaheim, CA |
| 23 | Fri Dec 3 | atCoyotes | W7-1 | 13-10-0 | 26 PTS | Mullett Arena · Tempe, AZ |
| 24 | Sun Dec 5 | vsFlames | W3-2 | 14-10-0 | 28 PTS | T-Mobile Arena · Las Vegas, NV |
| 25 | Wed Dec 8 | vsStars | W5-4 | 15-10-0 | 30 PTS | T-Mobile Arena · Las Vegas, NV |
| 26 | Fri Dec 10 | vsFlyers | L3-4 | 15-11-0 | 30 PTS | T-Mobile Arena · Las Vegas, NV |
| 27 | Sun Dec 12 | vsWild | W6-4 | 16-11-0 | 32 PTS | T-Mobile Arena · Las Vegas, NV |
| 28 | Tue Dec 14 | atBruins | W4-1 | 17-11-0 | 34 PTS | TD Garden · Boston, MA |
| 29 | Thu Dec 16 | atDevils | W5-3 | 18-11-0 | 36 PTS | Prudential Center · Newark, NJ |
| 30 | Fri Dec 17 | atRangers | W3-2 (SO) | 19-11-0 | 38 PTS | Madison Square Garden · Manhattan, NY |
| 31 | Sun Dec 19 | atIslanders | W4-3 (SO) | 20-11-0 | 40 PTS | UBS Arena · Elmont, NY |
| 32 | Tue Dec 21 | vsLightning | L3-4 | 20-12-0 | 40 PTS | T-Mobile Arena · Las Vegas, NV |
| 33 | Tue Dec 28 | atKings | W6-3 | 21-12-0 | 42 PTS | Crypto.com Arena · Los Angeles, CA |
| 34 | Fri Dec 31 | vsDucks | W3-1 | 22-12-0 | 44 PTS | T-Mobile Arena · Las Vegas, NV |
| 35 | Sun Jan 2 | vsJets | L4-5 (OT) | 22-12-1 | 45 PTS | T-Mobile Arena · Las Vegas, NV |
| 36 | Tue Jan 4 | vsPredators | L2-3 | 22-13-1 | 45 PTS | T-Mobile Arena · Las Vegas, NV |
| 37 | Thu Jan 6 | vsRangers | W5-1 | 23-13-1 | 47 PTS | T-Mobile Arena · Las Vegas, NV |
| 38 | Sat Jan 8 | vsBlackhawks | L1-2 | 23-14-1 | 47 PTS | T-Mobile Arena · Las Vegas, NV |
| 39 | Tue Jan 11 | vsMaple Leafs | L3-4 (SO) | 23-14-2 | 48 PTS | T-Mobile Arena · Las Vegas, NV |
| 40 | Mon Jan 17 | vsPenguins | L3-5 | 23-15-2 | 48 PTS | T-Mobile Arena · Las Vegas, NV |
| 41 | Thu Jan 20 | vsCanadiens | W4-3 (OT) | 24-15-2 | 50 PTS | T-Mobile Arena · Las Vegas, NV |
| 42 | Mon Jan 24 | atCapitals | W1-0 | 25-15-2 | 52 PTS | Capital One Arena · Washington, D.C. |
| 43 | Tue Jan 25 | atHurricanes | L3-4 (OT) | 25-15-3 | 53 PTS | PNC Arena · Raleigh, NC |
| 44 | Thu Jan 27 | atPanthers | L1-4 | 25-16-3 | 53 PTS | Amerant Bank Arena · Sunrise, FL |
| 45 | Sat Jan 29 | atLightning | W3-2 (SO) | 26-16-3 | 55 PTS | AMALIE Arena · Tampa, FL |
| 46 | Tue Feb 1 | vsSabres | W5-2 | 27-16-3 | 57 PTS | T-Mobile Arena · Las Vegas, NV |
| 47 | Tue Feb 8 | atOilers | W4-0 | 28-16-3 | 59 PTS | Rogers Place · Edmonton, AB |
| 48 | Wed Feb 9 | atFlames | L0-6 | 28-17-3 | 59 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 49 | Wed Feb 16 | vsAvalanche | L0-2 | 28-18-3 | 59 PTS | T-Mobile Arena · Las Vegas, NV |
| 50 | Fri Feb 18 | vsKings | L3-4 (OT) | 28-18-4 | 60 PTS | T-Mobile Arena · Las Vegas, NV |
| 51 | Sun Feb 20 | atSharks | W4-1 | 29-18-4 | 62 PTS | SAP Center · San Jose, CA |
| 52 | Fri Feb 25 | atCoyotes | L1-3 | 29-19-4 | 62 PTS | Mullett Arena · Tempe, AZ |
| 53 | Sat Feb 26 | vsAvalanche | L2-3 | 29-20-4 | 62 PTS | T-Mobile Arena · Las Vegas, NV |
| 54 | Tue Mar 1 | vsSharks | W3-1 | 30-20-4 | 64 PTS | T-Mobile Arena · Las Vegas, NV |
| 55 | Thu Mar 3 | vsBruins | L2-5 | 30-21-4 | 64 PTS | T-Mobile Arena · Las Vegas, NV |
| 56 | Fri Mar 4 | atDucks | W5-4 | 31-21-4 | 66 PTS | Honda Center · Anaheim, CA |
| 57 | Sun Mar 6 | vsSenators | W2-1 | 32-21-4 | 68 PTS | T-Mobile Arena · Las Vegas, NV |
| 58 | Tue Mar 8 | atFlyers | L1-2 | 32-22-4 | 68 PTS | Wells Fargo Center · Philadelphia, PA |
| 59 | Thu Mar 10 | atSabres | L1-3 | 32-23-4 | 68 PTS | KeyBank Center · Buffalo, NY |
| 60 | Fri Mar 11 | atPenguins | L2-5 | 32-24-4 | 68 PTS | PPG Paints Arena · Pittsburgh, PA |
| 61 | Sun Mar 13 | atJackets | L4-6 | 32-25-4 | 68 PTS | Nationwide Arena · Columbus, OH |
| 62 | Tue Mar 15 | atJets | L3-7 | 32-26-4 | 68 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 63 | Thu Mar 17 | vsPanthers | W5-3 | 33-26-4 | 70 PTS | T-Mobile Arena · Las Vegas, NV |
| 64 | Sat Mar 19 | vsKings | W5-1 | 34-26-4 | 72 PTS | T-Mobile Arena · Las Vegas, NV |
| 65 | Mon Mar 21 | atWild | L0-3 | 34-27-4 | 72 PTS | Xcel Energy Center · St. Paul, MN |
| 66 | Tue Mar 22 | atJets | L0-4 | 34-28-4 | 72 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 67 | Thu Mar 24 | vsPredators | W6-1 | 35-28-4 | 74 PTS | T-Mobile Arena · Las Vegas, NV |
| 68 | Sat Mar 26 | vsBlackhawks | W5-4 (OT) | 36-28-4 | 76 PTS | T-Mobile Arena · Las Vegas, NV |
| 69 | Wed Mar 30 | atKraken | W3-0 | 37-28-4 | 78 PTS | Climate Pledge Arena · Seattle, WA |
| 70 | Fri Apr 1 | atKraken | W5-2 | 38-28-4 | 80 PTS | Climate Pledge Arena · Seattle, WA |
| 71 | Sun Apr 3 | atCanucks | W3-2 (OT) | 39-28-4 | 82 PTS | Rogers Arena · Vancouver, British Columbia |
| 72 | Wed Apr 6 | vsCanucks | L1-5 | 39-29-4 | 82 PTS | T-Mobile Arena · Las Vegas, NV |
| 73 | Sat Apr 9 | vsCoyotes | W6-1 | 40-29-4 | 84 PTS | T-Mobile Arena · Las Vegas, NV |
| 74 | Tue Apr 12 | atCanucks | L4-5 (OT) | 40-29-5 | 85 PTS | Rogers Arena · Vancouver, British Columbia |
| 75 | Thu Apr 14 | atFlames | W6-1 | 41-29-5 | 87 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 76 | Sat Apr 16 | atOilers | L0-4 | 41-30-5 | 87 PTS | Rogers Place · Edmonton, AB |
| 77 | Mon Apr 18 | vsDevils | L2-3 | 41-31-5 | 87 PTS | T-Mobile Arena · Las Vegas, NV |
| 78 | Wed Apr 20 | vsCapitals | W4-3 (OT) | 42-31-5 | 89 PTS | T-Mobile Arena · Las Vegas, NV |
| 79 | Sun Apr 24 | vsSharks | L4-5 (SO) | 42-31-6 | 90 PTS | T-Mobile Arena · Las Vegas, NV |
| 80 | Tue Apr 26 | atStars | L2-3 (SO) | 42-31-7 | 91 PTS | American Airlines Center · Dallas, TX |
| 81 | Wed Apr 27 | atBlackhawks | L3-4 (SO) | 42-31-8 | 92 PTS | United Center · Chicago, IL |
| 82 | Fri Apr 29 | atBlues | W7-4 | 43-31-8 | 94 PTS | Enterprise Center · St. Louis, MO |
