| 1 | Thu Mar 26 | vs Angels | L0-3 | 0-1 | .000 | Minute Maid Park · Houston, TX |
| 2 | Fri Mar 27 | vs Angels | L2-6 | 0-2 | .000 | Minute Maid Park · Houston, TX |
| 3 | Sat Mar 28 | vs Angels | W11-9 | 1-2 | .333 | Minute Maid Park · Houston, TX |
| 4 | Sun Mar 29 | vs Angels | W9-7 | 2-2 | .500 | Minute Maid Park · Houston, TX |
| 5 | Mon Mar 30 | vs Red Sox | W8-1 | 3-2 | .600 | Minute Maid Park · Houston, TX |
| 6 | Tue Mar 31 | vs Red Sox | W9-2 | 4-2 | .667 | Minute Maid Park · Houston, TX |
| 7 | Wed Apr 1 | vs Red Sox | W6-4 | 5-2 | .714 | Minute Maid Park · Houston, TX |
| 8 | Fri Apr 3 | at Athletics | L4-11 | 5-3 | .625 | Sutter Health Park · West Sacramento, CA |
| 9 | Sat Apr 4 | at Athletics | W11-0 | 6-3 | .667 | Sutter Health Park · West Sacramento, CA |
| 10 | Sun Apr 5 | at Athletics | L10-12 (10) | 6-4 | .600 | Sutter Health Park · West Sacramento, CA |
| 11 | Mon Apr 6 | at Rockies | L7-9 | 6-5 | .545 | Coors Field · Denver, CO |
| 12 | Tue Apr 7 | at Rockies | L1-5 | 6-6 | .500 | Coors Field · Denver, CO |
| 13 | Wed Apr 8 | at Rockies | L1-9 | 6-7 | .462 | Coors Field · Denver, CO |
| 14 | Fri Apr 10 | at Mariners | L6-9 | 6-8 | .429 | T-Mobile Park · Seattle, WA |
| 15 | Sat Apr 11 | at Mariners | L7-8 | 6-9 | .400 | T-Mobile Park · Seattle, WA |
| 16 | Sun Apr 12 | at Mariners | L1-6 | 6-10 | .375 | T-Mobile Park · Seattle, WA |
| 17 | Mon Apr 13 | at Mariners | L2-6 | 6-11 | .353 | T-Mobile Park · Seattle, WA |
| 18 | Tue Apr 14 | vs Rockies | W7-6 | 7-11 | .389 | Minute Maid Park · Houston, TX |
| 19 | Wed Apr 15 | vs Rockies | W3-1 | 8-11 | .421 | Minute Maid Park · Houston, TX |
| 20 | Thu Apr 16 | vs Rockies | L2-3 | 8-12 | .400 | Minute Maid Park · Houston, TX |
| 21 | Fri Apr 17 | vs Cardinals | L4-9 | 8-13 | .381 | Minute Maid Park · Houston, TX |
| 22 | Sat Apr 18 | vs Cardinals | L5-7 | 8-14 | .364 | Minute Maid Park · Houston, TX |
| 23 | Sun Apr 19 | vs Cardinals | L5-7 (10) | 8-15 | .348 | Minute Maid Park · Houston, TX |
| 24 | Mon Apr 20 | at Guardians | W9-2 | 9-15 | .375 | Progressive Field · Cleveland, OH |
| 25 | Tue Apr 21 | at Guardians | L5-8 | 9-16 | .360 | Progressive Field · Cleveland, OH |
| 26 | Wed Apr 22 | at Guardians | W2-0 | 10-16 | .385 | Progressive Field · Cleveland, OH |
| 27 | Fri Apr 24 | vs Yankees | L4-12 | 10-17 | .370 | Minute Maid Park · Houston, TX |
| 28 | Sat Apr 25 | vs Yankees | L3-8 | 10-18 | .357 | Minute Maid Park · Houston, TX |
| 29 | Sun Apr 26 | vs Yankees | W7-4 | 11-18 | .379 | Minute Maid Park · Houston, TX |
| 30 | Tue Apr 28 | at Orioles | L3-5 | 11-19 | .367 | Camden Yards · Baltimore, MD |
| 31 | Thu Apr 30 | at Orioles | L3-10 | 11-20 | .355 | Camden Yards · Baltimore, MD |
| 32 | Thu Apr 30 | at Orioles | W11-5 | 12-20 | .375 | Camden Yards · Baltimore, MD |
| 33 | Fri May 1 | at Red Sox | L1-3 | 12-21 | .364 | Fenway Park · Boston, MA |
| 34 | Sat May 2 | at Red Sox | W6-3 | 13-21 | .382 | Fenway Park · Boston, MA |
| 35 | Sun May 3 | at Red Sox | W3-1 (10) | 14-21 | .400 | Fenway Park · Boston, MA |
| 36 | Mon May 4 | vs Dodgers | L3-8 | 14-22 | .389 | Minute Maid Park · Houston, TX |
| 37 | Tue May 5 | vs Dodgers | W2-1 | 15-22 | .405 | Minute Maid Park · Houston, TX |
| 38 | Wed May 6 | vs Dodgers | L2-12 | 15-23 | .395 | Minute Maid Park · Houston, TX |
| 39 | Fri May 8 | at Reds | W10-0 | 16-23 | .410 | Great American Ball Park · Cincinnati, OH |
| 40 | Sat May 9 | at Reds | L1-3 | 16-24 | .400 | Great American Ball Park · Cincinnati, OH |
| 41 | Sun May 10 | at Reds | L0-5 | 16-25 | .390 | Great American Ball Park · Cincinnati, OH |
| 42 | Mon May 11 | vs Mariners | L1-3 | 16-26 | .381 | Minute Maid Park · Houston, TX |
| 43 | Tue May 12 | vs Mariners | L2-10 | 16-27 | .372 | Minute Maid Park · Houston, TX |
| 44 | Wed May 13 | vs Mariners | W4-3 (10) | 17-27 | .386 | Minute Maid Park · Houston, TX |
| 45 | Thu May 14 | vs Mariners | L3-8 | 17-28 | .378 | Minute Maid Park · Houston, TX |
| 46 | Fri May 15 | vs Rangers | W2-0 | 18-28 | .391 | Minute Maid Park · Houston, TX |
| 47 | Sat May 16 | vs Rangers | W4-1 | 19-28 | .404 | Minute Maid Park · Houston, TX |
| 48 | Sun May 17 | vs Rangers | L0-8 | 19-29 | .396 | Minute Maid Park · Houston, TX |
| 49 | Mon May 18 | at Twins | L3-6 | 19-30 | .388 | Target Field · Minneapolis, MN |
| 50 | Tue May 19 | at Twins | W2-1 | 20-30 | .400 | Target Field · Minneapolis, MN |
| 51 | Wed May 20 | at Twins | L1-4 | 20-31 | .392 | Target Field · Minneapolis, MN |
| 52 | Fri May 22 | at Cubs | W4-2 | 21-31 | .404 | Wrigley Field · Chicago, IL |
| 53 | Sat May 23 | at Cubs | W3-0 | 22-31 | .415 | Wrigley Field · Chicago, IL |
| 54 | Sun May 24 | at Cubs | W8-5 | 23-31 | .426 | Wrigley Field · Chicago, IL |
| 55 | Mon May 25 | at Rangers | W9-0 | 24-31 | .436 | Globe Life Field · Arlington, TX |
| 56 | Tue May 26 | at Rangers | L7-10 | 24-32 | .429 | Globe Life Field · Arlington, TX |
| 57 | Wed May 27 | at Rangers | W4-3 | 25-32 | .439 | Globe Life Field · Arlington, TX |
| 58 | Thu May 28 | at Rangers | W5-1 | 26-32 | .448 | Globe Life Field · Arlington, TX |
| 59 | Fri May 29 | vs Brewers | L4-5 (10) | 26-33 | .441 | Minute Maid Park · Houston, TX |
| 60 | Sat May 30 | vs Brewers | W9-2 | 27-33 | .450 | Minute Maid Park · Houston, TX |
| 61 | Sun May 31 | vs Brewers | L0-2 | 27-34 | .443 | Minute Maid Park · Houston, TX |
| 62 | Tue Jun 2 | vs Pirates | L6-10 | 27-35 | .435 | Minute Maid Park · Houston, TX |
| 63 | Wed Jun 3 | vs Pirates | W11-9 | 28-35 | .444 | Minute Maid Park · Houston, TX |
| 64 | Thu Jun 4 | vs Pirates | L1-5 | 28-36 | .438 | Minute Maid Park · Houston, TX |
| 65 | Fri Jun 5 | vs Athletics | W5-1 | 29-36 | .446 | Minute Maid Park · Houston, TX |
| 66 | Sat Jun 6 | vs Athletics | W13-2 | 30-36 | .455 | Minute Maid Park · Houston, TX |
| 67 | Sun Jun 7 | vs Athletics | L0-5 | 30-37 | .448 | Minute Maid Park · Houston, TX |
| 68 | Mon Jun 8 | at Angels | W5-4 (10) | 31-37 | .456 | Angel Stadium · Anaheim, CA |
| 69 | Tue Jun 9 | at Angels | L1-10 | 31-38 | .449 | Angel Stadium · Anaheim, CA |
| 70 | Wed Jun 10 | at Angels | L2-3 (10) | 31-39 | .443 | Angel Stadium · Anaheim, CA |
| 71 | Fri Jun 12 | at Royals | W10-8 | 32-39 | .451 | Kauffman Stadium · Kansas City, MO |
| 72 | Sat Jun 13 | at Royals | W8-7 | 33-39 | .458 | Kauffman Stadium · Kansas City, MO |
| 73 | Sun Jun 14 | at Royals | L0-4 | 33-40 | .452 | Kauffman Stadium · Kansas City, MO |
| 74 | Mon Jun 15 | vs Tigers | L3-9 | 33-41 | .446 | Minute Maid Park · Houston, TX |
| 75 | Tue Jun 16 | vs Tigers | W4-2 | 34-41 | .453 | Minute Maid Park · Houston, TX |
| 76 | Wed Jun 17 | vs Tigers | W4-2 | 35-41 | .461 | Minute Maid Park · Houston, TX |
| 77 | Fri Jun 19 | vs Guardians | W9-3 | 36-41 | .468 | Minute Maid Park · Houston, TX |
| 78 | Sat Jun 20 | vs Guardians | L1-8 | 36-42 | .462 | Minute Maid Park · Houston, TX |
| 79 | Sun Jun 21 | vs Guardians | W2-1 | 37-42 | .468 | Minute Maid Park · Houston, TX |
| 80 | Mon Jun 22 | at Blue Jays | L2-4 | 37-43 | .463 | Rogers Centre · Toronto, ON |
| 81 | Tue Jun 23 | at Blue Jays | W9-7 (11) | 38-43 | .469 | Rogers Centre · Toronto, ON |
| 82 | Wed Jun 24 | at Blue Jays | W3-1 | 39-43 | .476 | Rogers Centre · Toronto, ON |
| 83 | Thu Jun 25 | at Tigers | W2-1 | 40-43 | .482 | Comerica Park · Detroit, MI |
| 84 | Fri Jun 26 | at Tigers | L0-8 | 40-44 | .476 | Comerica Park · Detroit, MI |
| 85 | Sat Jun 27 | at Tigers | W8-6 | 41-44 | .482 | Comerica Park · Detroit, MI |
| 86 | Sun Jun 28 | at Tigers | W7-5 (10) | 42-44 | .488 | Comerica Park · Detroit, MI |
| 87 | Mon Jun 29 | vs Twins | L4-5 | 42-45 | .483 | Minute Maid Park · Houston, TX |
| 88 | Tue Jun 30 | vs Twins | W6-4 | 43-45 | .489 | Minute Maid Park · Houston, TX |
| 89 | Wed Jul 1 | vs Twins | L3-8 | 43-46 | .483 | Minute Maid Park · Houston, TX |
| 90 | Fri Jul 3 | vs Rays | L1-3 | 43-47 | .478 | Minute Maid Park · Houston, TX |
| 91 | Sat Jul 4 | vs Rays | W10-8 | 44-47 | .484 | Minute Maid Park · Houston, TX |
| 92 | Sun Jul 5 | vs Rays | W2-0 | 45-47 | .489 | Minute Maid Park · Houston, TX |
| 93 | Mon Jul 6 | at Nationals | L11-12 | 45-48 | .484 | Nationals Park · Washington, D.C. |
| 94 | Tue Jul 7 | at Nationals | W6-3 | 46-48 | .489 | Nationals Park · Washington, D.C. |
| 95 | Wed Jul 8 | at Nationals | L2-8 | 46-49 | .484 | Nationals Park · Washington, D.C. |
| 96 | Fri Jul 10 | at Rangers | L3-7 | 46-50 | .479 | Globe Life Field · Arlington, TX |
| 97 | Sat Jul 11 | at Rangers | W9-3 | 47-50 | .485 | Globe Life Field · Arlington, TX |
| 98 | Sun Jul 12 | at Rangers | L5-6 | 47-51 | .480 | Globe Life Field · Arlington, TX |