| 1 | Mon Nov 7 | at #23Illinois | L57-87 | 0-1 | .000 | - | ESPNU | State Farm Center · Champaign, IL |
| 2 | Thu Nov 10 | vs Illinois St | L49-54 | 0-2 | .000 | - | | Lantz Arena · Charleston, IL |
| 3 | Sun Nov 13 | at C Michigan | L60-76 | 0-3 | .000 | - | | McGuirk Arena · Mount Pleasant, MI |
| 4 | Wed Nov 16 | at Ohio State | L43-65 | 0-4 | .000 | - | BTN | Value City Arena · Columbus, OH |
| 5 | Mon Nov 21 | vs TBD | W102-40 | 1-4 | .200 | - | | Lantz Arena · Charleston, IL |
| 6 | Fri Nov 25 | at Ohio | L67-78 | 1-5 | .167 | - | | Convocation Center (OH) · Athens, OH |
| 7 | Sat Nov 26 | vs Alabama St | L58-67 | 1-6 | .143 | - | | Lantz Arena · Charleston, IL |
| 8 | Wed Nov 30 | vs N Illinois | L70-90 | 1-7 | .125 | - | | Lantz Arena · Charleston, IL |
| 9 | Sat Dec 3 | vsTBD | W93-43 | 2-7 | .222 | - | | Lantz Arena · Charleston, IL |
| 10 | Wed Dec 7 | vs Ball State | L59-76 | 2-8 | .200 | - | | Lantz Arena · Charleston, IL |
| 11 | Sat Dec 10 | vs W Illinois | L75-79 | 2-9 | .182 | - | | Lantz Arena · Charleston, IL |
| 12 | Sat Dec 17 | at IU Indy | W70-59 | 3-9 | .250 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 13 | Wed Dec 21 | at Iowa | W92-83 | 4-9 | .308 | - | | Carver-Hawkeye Arena · Iowa City, IA |
| 14 | Thu Dec 29 | vs Lindenwood | W55-54 | 5-9 | .357 | - | | Lantz Arena · Charleston, IL |
| 15 | Sat Dec 31 | vs So Indiana | W91-80 | 6-9 | .400 | - | | Lantz Arena · Charleston, IL |
| 16 | Thu Jan 5 | at Tennessee Tech | L49-70 | 6-10 | .375 | - | | Hooper Eblen Center · Cookeville, TN |
| 17 | Sat Jan 7 | at Morehead St | L59-69 | 6-11 | .353 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 18 | Thu Jan 12 | vs SIUE | L62-80 | 6-12 | .333 | - | | Lantz Arena · Charleston, IL |
| 19 | Sat Jan 14 | vs Little Rock | W70-63 | 7-12 | .368 | - | | Lantz Arena · Charleston, IL |
| 20 | Thu Jan 19 | at Tennessee St | L74-78 | 7-13 | .350 | - | | Gentry Center · Nashville, TN |
| 21 | Sat Jan 21 | at UT Martin | L78-91 | 7-14 | .333 | - | | Kathleen and Tom Elam Center · Martin, TN |
| 22 | Thu Jan 26 | atSo Indiana | L74-78 | 7-15 | .318 | - | | Screaming Eagles Arena · Evansville, IN |
| 23 | Sat Jan 28 | vs SE Missouri St | L68-79 | 7-16 | .304 | - | | Lantz Arena · Charleston, IL |
| 24 | Thu Feb 2 | atLindenwood | L67-80 | 7-17 | .292 | - | | placeholder · sf, ca |
| 25 | Sat Feb 4 | vsTennessee St | L61-65 | 7-18 | .280 | - | | Lantz Arena · Charleston, IL |
| 26 | Thu Feb 9 | vsUT Martin | W77-75 | 8-18 | .308 | - | | Lantz Arena · Charleston, IL |
| 27 | Sat Feb 11 | atSIUE | W84-73 | 9-18 | .333 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 28 | Thu Feb 16 | atSE Missouri St | L64-78 | 9-19 | .321 | - | | Show Me Center · Cape Girardeau, MO |
| 29 | Sat Feb 18 | atLittle Rock | L77-81 (OT) | 9-20 | .310 | - | | Jack Stephens Center · Little Rock, AR |
| 30 | Wed Feb 22 | vsMorehead St | L63-69 | 9-21 | .300 | - | | Lantz Arena · Charleston, IL |
| 31 | Sat Feb 25 | vsTennessee Tech | L66-75 | 9-22 | .290 | - | | Lantz Arena · Charleston, IL |
