| 1 | Tue Nov 5 | at #13Texas Tech | L60-85 | 0-1 | .000 | - | | United Supermarkets Arena · Lubbock, TX |
| 2 | Fri Nov 8 | atWisconsin | L52-65 | 0-2 | .000 | - | | Kohl Center · Madison, WI |
| 3 | Tue Nov 12 | vsChicago St | W98-34 | 1-2 | .333 | - | | Lantz Arena · Charleston, IL |
| 4 | Mon Nov 18 | vsTBD | W114-61 | 2-2 | .500 | - | | Lantz Arena · Charleston, IL |
| 5 | Fri Nov 22 | vsTBD | W87-47 | 3-2 | .600 | - | | Lantz Arena · Charleston, IL |
| 6 | Sat Nov 23 | vsBethune | L63-66 | 3-3 | .500 | - | | Lantz Arena · Charleston, IL |
| 7 | Sun Nov 24 | atIncarnate Word | W72-63 | 4-3 | .571 | - | | Alice P. McDermott Convocation Center · San Antonio, TX |
| 8 | Wed Dec 4 | atPurdue FW | L69-74 | 4-4 | .500 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 9 | Sat Dec 7 | vsGreen Bay | W93-80 | 5-4 | .556 | - | | Lantz Arena · Charleston, IL |
| 10 | Sat Dec 14 | atMilwaukee | W75-68 | 6-4 | .600 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 11 | Mon Dec 16 | atW Illinois | W85-47 | 7-4 | .636 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 12 | Sat Dec 21 | atGrand Canyon | L63-85 | 7-5 | .583 | - | | GCU Arena · Phoenix, AZ |
| 13 | Thu Jan 2 | atTennessee St | L79-84 | 7-6 | .538 | - | | Gentry Center · Nashville, TN |
| 14 | Sat Jan 4 | atBelmont | L55-87 | 7-7 | .500 | - | | Curb Event Center Arena · Nashville, TN |
| 15 | Thu Jan 9 | atE Kentucky | L74-77 | 7-8 | .467 | - | | McBrayer Arena · Richmond, KY |
| 16 | Sat Jan 11 | atMorehead St | L66-69 | 7-9 | .438 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 17 | Thu Jan 16 | vsJ'Ville St | W70-69 | 8-9 | .471 | - | | Lantz Arena · Charleston, IL |
| 18 | Sat Jan 18 | vsTennessee Tech | W84-59 | 9-9 | .500 | - | | Lantz Arena · Charleston, IL |
| 19 | Thu Jan 23 | vsUT Martin | W95-83 | 10-9 | .526 | - | | Lantz Arena · Charleston, IL |
| 20 | Sat Jan 25 | vsSE Missouri St | W61-59 | 11-9 | .550 | - | | Lantz Arena · Charleston, IL |
| 21 | Thu Jan 30 | atMurray St | L70-73 | 11-10 | .524 | - | | CFSB Center · Murray, KY |
| 22 | Sat Feb 1 | atAustin Peay | L64-68 | 11-11 | .500 | - | | Winfield Dunn Center · Clarksville, TN |
| 23 | Thu Feb 6 | vsE Kentucky | L84-91 | 11-12 | .478 | - | | Lantz Arena · Charleston, IL |
| 24 | Sat Feb 8 | vsMorehead St | W71-65 | 12-12 | .500 | - | | Lantz Arena · Charleston, IL |
| 25 | Thu Feb 13 | vsSIUE | L74-76 | 12-13 | .480 | - | | Lantz Arena · Charleston, IL |
| 26 | Sat Feb 15 | atUT Martin | L79-80 (OT) | 12-14 | .462 | - | | Kathleen and Tom Elam Center · Martin, TN |
| 27 | Thu Feb 20 | vsMurray St | W63-60 | 13-14 | .481 | - | | Lantz Arena · Charleston, IL |
| 28 | Sat Feb 22 | vsAustin Peay | W83-80 (OT) | 14-14 | .500 | - | | Lantz Arena · Charleston, IL |
| 29 | Thu Feb 27 | atSE Missouri St | W72-70 | 15-14 | .517 | - | | Show Me Center · Cape Girardeau, MO |
| 30 | Sat Feb 29 | atSIUE | W70-52 | 16-14 | .533 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 31 | Wed Mar 4 | vsJ'Ville St | W67-61 | 17-14 | .548 | - | | Lantz Arena · Charleston, IL |
| 32 | Thu Mar 5 | atAustin Peay | L65-76 | 17-15 | .531 | - | | Winfield Dunn Center · Clarksville, TN |
