| 3 | Tue Nov 11 | at Notre Dame | 7:30 PM | 2-0 | 1.000 | - | ACC Extra | Purcell Pavilion · South Bend, IN |
| 4 | Fri Nov 14 | at#9Kentucky | 7:00 PM | 2-0 | 1.000 | - | SECN+ | Rupp Arena · Lexington, KY |
| 5 | Wed Nov 19 | vsTBD | 8:00 PM | 0-0 | .000 | - | ESPN+ | Lantz Arena · Charleston, IL |
| 6 | Tue Nov 25 | atC Arkansas | 7:30 PM | 0-1 | .000 | - | ESPN+ | Farris Center · Conway, AR |
| 7 | Fri Nov 28 | at#1Purdue | 12:00 PM | 2-0 | 1.000 | - | | Mackey Arena · West Lafayette, IN |
| 8 | Mon Dec 1 | vsTBD | 8:00 PM | 0-0 | .000 | - | ESPN+ | Lantz Arena · Charleston, IL |
| 9 | Sat Dec 6 | vsLindenwood | 8:00 PM | 1-1 | .500 | - | ESPN+ | Lantz Arena · Charleston, IL |
| 10 | Wed Dec 10 | vsE Kentucky | 8:00 PM | 1-0 | 1.000 | - | ESPN+ | Lantz Arena · Charleston, IL |
| 11 | Sun Dec 14 | at#16Iowa State | 1:00 PM | 2-0 | 1.000 | - | ESPN+ | James H. Hilton Coliseum · Ames, IA |
| 12 | Thu Dec 18 | vsSIUE | 6:30 PM | 2-0 | 1.000 | - | ESPN+ | Lantz Arena · Charleston, IL |
| 13 | Mon Dec 22 | vsTBD | 3:00 PM | 0-0 | .000 | - | ESPN+ | Lantz Arena · Charleston, IL |
| 14 | Thu Jan 1 | atSE Missouri St | 8:30 PM | 0-2 | .000 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 15 | Sat Jan 3 | atUT Martin | 4:30 PM | 1-0 | 1.000 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 16 | Thu Jan 8 | vsTennessee Tech | 8:30 PM | 0-2 | .000 | - | ESPN+ | Lantz Arena · Charleston, IL |
| 17 | Sat Jan 10 | vsTennessee St | 4:30 PM | 1-0 | 1.000 | - | ESPN+ | Lantz Arena · Charleston, IL |
| 18 | Tue Jan 13 | vsW Illinois | 8:30 PM | 0-2 | .000 | - | ESPN+ | Lantz Arena · Charleston, IL |
| 19 | Thu Jan 15 | atLittle Rock | 8:00 PM | 1-0 | 1.000 | - | ESPN+ | Jack Stephens Center · Little Rock, AR |
| 20 | Thu Jan 22 | atSo Indiana | 8:30 PM | 0-2 | .000 | - | ESPN+ | Screaming Eagles Arena · Evansville, IN |
| 21 | Sat Jan 24 | atMorehead St | 3:30 PM | 1-1 | .500 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 22 | Thu Jan 29 | vsUT Martin | 8:30 PM | 1-0 | 1.000 | - | ESPN+ | Lantz Arena · Charleston, IL |
| 23 | Sat Jan 31 | vsSE Missouri St | 4:30 PM | 0-2 | .000 | - | ESPN+ | Lantz Arena · Charleston, IL |
| 24 | Thu Feb 5 | atTennessee St | 8:30 PM | 1-0 | 1.000 | - | ESPN+ | Gentry Center · Nashville, TN |
| 25 | Sat Feb 7 | atTennessee Tech | 4:00 PM | 0-2 | .000 | - | ESPN+ | Hooper Eblen Center · Cookeville, TN |
| 26 | Tue Feb 10 | atW Illinois | 8:30 PM | 0-2 | .000 | - | ESPN+ | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 27 | Sat Feb 14 | vsLittle Rock | 4:30 PM | 1-0 | 1.000 | - | ESPN+ | Lantz Arena · Charleston, IL |
| 28 | Thu Feb 19 | vsMorehead St | 8:30 PM | 1-1 | .500 | - | ESPN+ | Lantz Arena · Charleston, IL |
| 29 | Sat Feb 21 | vsSo Indiana | 4:30 PM | 0-2 | .000 | - | ESPN+ | Lantz Arena · Charleston, IL |
| 30 | Thu Feb 26 | atLindenwood | 8:30 PM | 1-1 | .500 | - | ESPN+ | placeholder · sf, ca |
| 31 | Sat Feb 28 | atSIUE | 4:30 PM | 2-0 | 1.000 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
