| 1 | Wed Nov 25 | at #7Wisconsin | L67-77 | 0-1 | .000 | - | BTN | Kohl Center · Madison, WI |
| 2 | Fri Nov 27 | atMarquette | L50-75 | 0-2 | .000 | - | | Fiserv Forum · Milwaukee, WI |
| 4 | Tue Dec 1 | atDayton | L63-66 | 0-3 | .000 | - | | UD Arena · Dayton, OH |
| 5 | Thu Dec 3 | vsChicago St | W78-56 | 1-3 | .250 | - | | Lantz Arena · Charleston, IL |
| 6 | Sat Dec 5 | atGreen Bay | W93-91 (2OT) | 2-3 | .400 | - | | Resch Center · Ashwaubenon, WI |
| 7 | Wed Dec 9 | atEvansville | L65-68 | 2-4 | .333 | - | | Ford Center · Evansville, IN |
| 8 | Sat Dec 12 | vsW Illinois | W92-88 | 3-4 | .429 | - | | Lantz Arena · Charleston, IL |
| 9 | Mon Dec 21 | atSIUE | PPD | 9-18 | .333 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 10 | Wed Dec 30 | atE Kentucky | L61-69 | 3-5 | .375 | - | | McBrayer Arena · Richmond, KY |
| 11 | Sat Jan 2 | vsTennessee Tech | W87-81 | 4-5 | .444 | - | | Lantz Arena · Charleston, IL |
| 12 | Tue Jan 5 | vsSIUE | PPD | 9-18 | .333 | - | | Lantz Arena · Charleston, IL |
| 13 | Thu Jan 7 | vsMurray St | W74-68 | 5-5 | .500 | - | | Lantz Arena · Charleston, IL |
| 14 | Sat Jan 9 | vsAustin Peay | L71-74 | 5-6 | .455 | - | | Lantz Arena · Charleston, IL |
| 15 | Tue Jan 12 | atSIUE | PPD | 9-18 | .333 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 16 | Thu Jan 14 | vsMorehead St | L61-87 | 5-7 | .417 | - | ESPNU | Lantz Arena · Charleston, IL |
| 17 | Sat Jan 16 | vsE Kentucky | L85-93 (OT) | 5-8 | .385 | - | | Lantz Arena · Charleston, IL |
| 18 | Thu Jan 21 | atBelmont | L66-79 | 5-9 | .357 | - | | Curb Event Center Arena · Nashville, TN |
| 19 | Sat Jan 23 | atTennessee St | L54-65 | 5-10 | .333 | - | | Gentry Center · Nashville, TN |
| 20 | Tue Jan 26 | vsSIUE | L74-87 | 5-11 | .313 | - | | Lantz Arena · Charleston, IL |
| 21 | Thu Jan 28 | atUT Martin | L41-51 | 5-12 | .294 | - | | Kathleen and Tom Elam Center · Martin, TN |
| 22 | Sat Jan 30 | atSE Missouri St | L44-75 | 5-13 | .278 | - | | Show Me Center · Cape Girardeau, MO |
| 23 | Tue Feb 2 | atSIUE | W70-61 | 6-13 | .316 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 24 | Thu Feb 4 | vsBelmont | L61-89 | 6-14 | .300 | - | | Lantz Arena · Charleston, IL |
| 25 | Sat Feb 6 | vsTennessee St | W86-72 | 7-14 | .333 | - | | Lantz Arena · Charleston, IL |
| 26 | Thu Feb 11 | atJ'Ville St | L64-76 | 7-15 | .318 | - | | Pete Mathews Coliseum · Jacksonville, AL |
| 27 | Sat Feb 13 | atTennessee Tech | L67-80 | 7-16 | .304 | - | | Hooper Eblen Center · Cookeville, TN |
| 28 | Thu Feb 18 | atMurray St | W68-59 | 8-16 | .333 | - | | CFSB Center · Murray, KY |
| 29 | Sat Feb 20 | atAustin Peay | W76-69 | 9-16 | .360 | - | | Winfield Dunn Center · Clarksville, TN |
| 30 | Thu Feb 25 | vsSE Missouri St | L88-94 | 9-17 | .346 | - | | Lantz Arena · Charleston, IL |
| 31 | Sat Feb 27 | vsUT Martin | L68-73 | 9-18 | .333 | - | | Lantz Arena · Charleston, IL |
