| 1 | Tue Nov 9 | at Northwestern | L56-80 | 0-1 | .000 | - | | Welsh-Ryan Arena · Evanston, IL |
| 2 | Fri Nov 12 | at Saint Louis | L44-86 | 0-2 | .000 | - | | Chaifetz Arena · St. Louis, MO |
| 3 | Mon Nov 15 | vs C Michigan | L61-62 | 0-3 | .000 | - | | Lantz Arena · Charleston, IL |
| 4 | Thu Nov 18 | vs TBD | W96-64 | 1-3 | .250 | - | | Lantz Arena · Charleston, IL |
| 5 | Mon Nov 22 | at E Kentucky | L43-82 | 1-4 | .200 | - | | McBrayer Arena · Richmond, KY |
| 6 | Wed Nov 24 | at Albany | L62-64 | 1-5 | .167 | - | | SEFCU Arena · Albany, NY |
| 7 | Sun Nov 28 | vs Evansville | L54-70 | 1-6 | .143 | - | | Lantz Arena · Charleston, IL |
| 8 | Wed Dec 1 | at N Illinois | L45-55 | 1-7 | .125 | - | | NIU Convocation Center · Dekalb, IL |
| 9 | Sat Dec 4 | vsTBD | W76-71 | 2-7 | .222 | - | | Lantz Arena · Charleston, IL |
| 10 | Tue Dec 7 | at Missouri | L44-72 | 2-8 | .200 | - | | Mizzou Arena · Columbia, MO |
| 11 | Sat Dec 11 | at Butler | L54-66 | 2-9 | .182 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 12 | Sat Dec 18 | at W Illinois | L54-71 | 2-10 | .167 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 13 | Tue Dec 21 | at Ball State | L55-75 | 2-11 | .154 | - | | Worthen Arena · Muncie, IN |
| 14 | Wed Dec 29 | at Morehead St | L50-63 | 2-12 | .143 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 15 | Sat Jan 1 | vs Belmont | PPD | 5-26 | .161 | - | | Lantz Arena · Charleston, IL |
| 16 | Thu Jan 6 | vs Murray St | PPD | 5-26 | .161 | - | | Lantz Arena · Charleston, IL |
| 17 | Thu Jan 13 | vs SIUE | L53-66 | 2-13 | .133 | - | ESPNEWS | Lantz Arena · Charleston, IL |
| 18 | Sat Jan 15 | at Austin Peay | PPD | 5-26 | .161 | - | | Winfield Dunn Center · Clarksville, TN |
| 19 | Mon Jan 17 | vsMurray St | L46-72 | 2-14 | .125 | - | | Lantz Arena · Charleston, IL |
| 20 | Thu Jan 20 | atMurray St | L51-91 | 2-15 | .118 | - | | CFSB Center · Murray, KY |
| 21 | Sat Jan 22 | vs SE Missouri St | L58-87 | 2-16 | .111 | - | | Lantz Arena · Charleston, IL |
| 22 | Mon Jan 24 | vsBelmont | L56-90 | 2-17 | .105 | - | | Lantz Arena · Charleston, IL |
| 23 | Thu Jan 27 | at UT Martin | W58-53 | 3-17 | .150 | - | | Kathleen and Tom Elam Center · Martin, TN |
| 24 | Sat Jan 29 | vs Tennessee St | W62-57 | 4-17 | .190 | - | | Lantz Arena · Charleston, IL |
| 25 | Thu Feb 3 | atSIUE | PPD | 5-26 | .161 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 26 | Sat Feb 5 | atSE Missouri St | L56-63 | 4-18 | .182 | - | | Show Me Center · Cape Girardeau, MO |
| 27 | Mon Feb 7 | at Tennessee Tech | L58-84 | 4-19 | .174 | - | | Hooper Eblen Center · Cookeville, TN |
| 28 | Thu Feb 10 | vsTennessee Tech | L62-73 | 4-20 | .167 | - | | Lantz Arena · Charleston, IL |
| 29 | Sat Feb 12 | vsUT Martin | W82-70 | 5-20 | .200 | - | | Lantz Arena · Charleston, IL |
| 30 | Mon Feb 14 | atAustin Peay | L54-62 | 5-21 | .192 | - | | Winfield Dunn Center · Clarksville, TN |
| 31 | Thu Feb 17 | atBelmont | L57-81 | 5-22 | .185 | - | | Curb Event Center Arena · Nashville, TN |
| 32 | Sat Feb 19 | atTennessee St | L49-63 | 5-23 | .179 | - | | Gentry Center · Nashville, TN |
| 33 | Mon Feb 21 | atSIUE | L52-66 | 5-24 | .172 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 34 | Thu Feb 24 | vsMorehead St | L46-82 | 5-25 | .167 | - | | Lantz Arena · Charleston, IL |
| 35 | Sat Feb 26 | vsAustin Peay | L52-64 | 5-26 | .161 | - | | Lantz Arena · Charleston, IL |
