| 1 | Mon Nov 6 | at #25Illinois | L52-80 | 0-1 | .000 | - | | State Farm Center · Champaign, IL |
| 2 | Wed Nov 8 | vs TBD | W91-45 | 1-1 | .500 | - | | Lantz Arena · Charleston, IL |
| 3 | Sat Nov 11 | at Loyola Chicago | L65-89 | 1-2 | .333 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 4 | Wed Nov 15 | at Illinois St | L61-69 | 1-3 | .250 | - | | Redbird Arena · Normal, IL |
| 5 | Sat Nov 18 | vs Coppin St | W48-46 | 2-3 | .400 | - | | Lantz Arena · Charleston, IL |
| 6 | Sun Nov 19 | at Miami OH | L64-76 | 2-4 | .333 | - | | Millett Hall · Oxford, OH |
| 7 | Sat Nov 25 | vsTBD | W85-39 | 3-4 | .429 | - | | Lantz Arena · Charleston, IL |
| 8 | Tue Nov 28 | at #5Kansas | L63-71 | 3-5 | .375 | - | | Allen Fieldhouse · Lawrence, KS |
| 9 | Sat Dec 2 | vsTBD | W112-50 | 4-5 | .444 | - | | Lantz Arena · Charleston, IL |
| 10 | Thu Dec 7 | vs IU Indy | W75-58 | 5-5 | .500 | - | | Lantz Arena · Charleston, IL |
| 11 | Sun Dec 10 | vs C Arkansas | L70-73 | 5-6 | .455 | - | | Lantz Arena · Charleston, IL |
| 12 | Sun Dec 17 | vsTBD | W87-66 | 6-6 | .500 | - | | Lantz Arena · Charleston, IL |
| 13 | Thu Dec 21 | at Iowa State | L48-80 | 6-7 | .462 | - | | James H. Hilton Coliseum · Ames, IA |
| 14 | Fri Dec 29 | at SIUE | L58-67 | 6-8 | .429 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 15 | Thu Jan 4 | at UT Martin | W79-72 | 7-8 | .467 | - | ESPNU | Kathleen and Tom Elam Center · Martin, TN |
| 16 | Sat Jan 6 | at Little Rock | W90-88 | 8-8 | .500 | - | | Jack Stephens Center · Little Rock, AR |
| 17 | Thu Jan 11 | vs Morehead St | L52-78 | 8-9 | .471 | - | | Lantz Arena · Charleston, IL |
| 18 | Sat Jan 13 | vs W Illinois | L60-63 | 8-10 | .444 | - | | Lantz Arena · Charleston, IL |
| 19 | Sat Jan 20 | at Lindenwood | W78-68 | 9-10 | .474 | - | | placeholder · sf, ca |
| 20 | Thu Jan 25 | vs Tennessee Tech | W68-59 | 10-10 | .500 | - | | Lantz Arena · Charleston, IL |
| 21 | Sat Jan 27 | vs Tennessee St | L60-64 | 10-11 | .476 | - | | Lantz Arena · Charleston, IL |
| 22 | Thu Feb 1 | vsUT Martin | L59-76 | 10-12 | .455 | - | | Lantz Arena · Charleston, IL |
| 23 | Sat Feb 3 | vsLittle Rock | L47-71 | 10-13 | .435 | - | | Lantz Arena · Charleston, IL |
| 24 | Thu Feb 8 | at So Indiana | W81-71 | 11-13 | .458 | - | | Screaming Eagles Arena · Evansville, IN |
| 25 | Sat Feb 10 | atMorehead St | L57-69 | 11-14 | .440 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 26 | Thu Feb 15 | vs SE Missouri St | W75-57 | 12-14 | .462 | - | | Lantz Arena · Charleston, IL |
| 27 | Sat Feb 17 | vsLindenwood | W72-57 | 13-14 | .481 | - | | Lantz Arena · Charleston, IL |
| 28 | Thu Feb 22 | atTennessee St | L73-78 | 13-15 | .464 | - | | Gentry Center · Nashville, TN |
| 29 | Sat Feb 24 | atTennessee Tech | L67-75 | 13-16 | .448 | - | | Hooper Eblen Center · Cookeville, TN |
| 30 | Tue Feb 27 | vsSIUE | W84-79 | 14-16 | .467 | - | | Lantz Arena · Charleston, IL |
| 31 | Thu Feb 29 | atW Illinois | L66-70 | 14-17 | .452 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 32 | Wed Mar 6 | atSIUE | L57-68 | 14-18 | .438 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
