| 1 | Mon Nov 3 | at Minnesota | L60-87 | 0-1 | .000 | - | B1G+ | Williams Arena · Minneapolis, MN |
| 2 | Fri Nov 7 | atClemson | L59-97 | 0-2 | .000 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 3 | Mon Nov 10 | vsTBD | L81-92 | 0-3 | .000 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 4 | Sat Nov 15 | atElon | L84-95 | 0-4 | .000 | - | | Schar Center · Elon, NC |
| 5 | Tue Nov 18 | atDePaul | L62-93 | 0-5 | .000 | - | ESPN+ | Wintrust Arena · Chicago, IL |
| 6 | Sat Nov 22 | atRichmond | L67-102 | 0-6 | .000 | - | ESPN+ | Robins Center · Richmond, VA |
| 7 | Wed Nov 26 | vsNavy | L51-84 | 0-7 | .000 | - | | Trask Coliseum · Wilmington, NC |
| 8 | Fri Nov 28 | vsSE Louisiana | L68-76 | 0-8 | .000 | - | | Trask Coliseum · Wilmington, NC |
| 9 | Sat Nov 29 | atUNC Wilmington | L62-88 | 0-9 | .000 | - | | Trask Coliseum · Wilmington, NC |
| 10 | Wed Dec 3 | atQueens | L74-107 | 0-10 | .000 | - | ESPN+ | Curry Arena · Charlotte, NC |
| 11 | Sat Dec 6 | vsGeorgia So | L84-88 | 0-11 | .000 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 12 | Fri Dec 12 | vsTBD | W77-63 | 1-11 | .083 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 13 | Mon Dec 15 | vsWofford | L57-83 | 1-12 | .077 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 14 | Thu Dec 18 | vsTBD | W105-65 | 2-12 | .143 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 15 | Sun Dec 21 | at20Tennessee | L52-94 | 2-13 | .133 | - | SECN+ | Thompson-Boling Arena · Knoxville, TN |
| 16 | Wed Dec 31 | vsCharleston So | L79-89 | 2-14 | .125 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 17 | Sat Jan 3 | atWinthrop | L77-88 | 2-15 | .118 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 18 | Wed Jan 7 | atHigh Point | L49-104 | 2-16 | .111 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 19 | Wed Jan 14 | vsRadford | L80-89 | 2-17 | .105 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 20 | Sat Jan 17 | vsPresbyterian | L55-92 | 2-18 | .100 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 21 | Wed Jan 21 | atLongwood | L56-91 | 2-19 | .095 | - | ESPN+ | Willett Hall · Farmville, VA |
| 22 | Fri Jan 23 | vsSC Upstate | W67-65 | 3-19 | .136 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 23 | Thu Jan 29 | atUNC Asheville | L50-69 | 3-20 | .130 | - | ESPN+ | Kimmel Arena · Asheville, NC |
| 24 | Wed Feb 4 | vsLongwood | L66-86 | 3-21 | .125 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 25 | Sat Feb 7 | atPresbyterian | L62-68 | 3-22 | .120 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 26 | Thu Feb 12 | vsWinthrop | L85-103 | 3-23 | .115 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 27 | Sat Feb 14 | vsHigh Point | L87-112 | 3-24 | .111 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 28 | Tue Feb 17 | atCharleston So | L66-75 | 3-25 | .107 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 29 | Thu Feb 19 | atRadford | L70-82 | 3-26 | .103 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 30 | Thu Feb 26 | vsUNC Asheville | L71-77 | 3-27 | .100 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 31 | Sat Feb 28 | atSC Upstate | L61-71 | 3-28 | .097 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
