| 1 | Wed Nov 25 | vs Drake | L70-80 | 0-1 | .000 | - | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 2 | Fri Nov 27 | vsColorado | L58-76 | 0-2 | .000 | - | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 3 | Mon Nov 30 | vsKansas City | W62-58 | 1-2 | .333 | - | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 4 | Sat Dec 5 | vsUNLV | L58-68 | 1-3 | .250 | - | | Bramlage Coliseum · Manhattan, KS |
| 5 | Tue Dec 8 | vsTBD | L68-81 | 1-4 | .200 | - | | Bramlage Coliseum · Manhattan, KS |
| 6 | Fri Dec 11 | vsMilwaukee | W76-75 | 2-4 | .333 | - | | Bramlage Coliseum · Manhattan, KS |
| 7 | Tue Dec 15 | atIowa State | W74-65 | 3-4 | .429 | - | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 8 | Sat Dec 19 | vs2Baylor | L69-100 | 3-5 | .375 | - | | Bramlage Coliseum · Manhattan, KS |
| 9 | Mon Dec 21 | vsJacksonville | W70-46 | 4-5 | .444 | - | | Bramlage Coliseum · Manhattan, KS |
| 10 | Tue Dec 29 | vsOmaha | W60-58 | 5-5 | .500 | - | | Bramlage Coliseum · Manhattan, KS |
| 11 | Sat Jan 2 | vsTCU | L60-67 | 5-6 | .455 | - | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 12 | Tue Jan 5 | at18Texas Tech | L71-82 | 5-7 | .417 | - | ESPNU | United Supermarkets Arena · Lubbock, TX |
| 13 | Sat Jan 9 | vsOklahoma St | L54-70 | 5-8 | .385 | - | ESPN2 | Bramlage Coliseum · Manhattan, KS |
| 14 | Wed Jan 13 | vsIowa State | PPD | 9-20 | .310 | - | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 15 | Sat Jan 16 | at4Texas | L67-82 | 5-9 | .357 | - | LHN | Moody Center · Austin, TX |
| 16 | Tue Jan 19 | atOklahoma | L50-76 | 5-10 | .333 | - | | Lloyd Noble Center · Norman, OK |
| 17 | Sat Jan 23 | vs14West Virginia | L47-69 | 5-11 | .313 | - | ESPN2 | Bramlage Coliseum · Manhattan, KS |
| 18 | Wed Jan 27 | at2Baylor | L59-107 | 5-12 | .294 | - | ESPN2 | Ferrell Center · Waco, TX |
| 19 | Sat Jan 30 | vsTexas A&M | L61-68 | 5-13 | .278 | - | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 20 | Tue Feb 2 | atKansas | L51-74 | 5-14 | .263 | - | | Allen Fieldhouse · Lawrence, KS |
| 21 | Sat Feb 6 | vs13Texas Tech | L62-73 | 5-15 | .250 | - | | Bramlage Coliseum · Manhattan, KS |
| 22 | Tue Feb 9 | vs13Texas | L77-80 | 5-16 | .238 | - | | Bramlage Coliseum · Manhattan, KS |
| 23 | Sat Feb 13 | at23Oklahoma St | L60-67 | 5-17 | .227 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 24 | Wed Feb 17 | vsKansas | L41-59 | 5-18 | .217 | - | | Bramlage Coliseum · Manhattan, KS |
| 25 | Sat Feb 20 | atTCU | W62-54 | 6-18 | .250 | - | | Schollmaier Arena · Fort Worth, TX |
| 26 | Tue Feb 23 | vs7Oklahoma | W62-57 | 7-18 | .280 | - | ESPN2 | Bramlage Coliseum · Manhattan, KS |
| 27 | Sat Feb 27 | at10West Virginia | L43-65 | 7-19 | .269 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 28 | Sat Mar 6 | vsIowa State | W61-56 | 8-19 | .296 | - | | Bramlage Coliseum · Manhattan, KS |
| 29 | Wed Mar 10 | atTCU | W71-50 | 9-19 | .321 | - | ESPN | T-Mobile Center · Kansas City, MOS |
| 30 | Thu Mar 11 | atBaylor | L68-74 | 9-20 | .310 | - | ESPN | T-Mobile Center · Kansas City, MOS |
