| 1 | Tue Nov 4 | vs UNC Greensboro | W93-64 | 1-0 | 1.000 | - | ESPN+ | Bramlage Coliseum · Manhattan, KS |
| 2 | Sat Nov 8 | vsBellarmine | W98-71 | 2-0 | 1.000 | - | ESPN+ | Bramlage Coliseum · Manhattan, KS |
| 3 | Thu Nov 13 | vsCalifornia | W99-96 | 3-0 | 1.000 | - | CBSSN | Bramlage Coliseum · Manhattan, KS |
| 4 | Mon Nov 17 | vsTulsa | W84-83 | 4-0 | 1.000 | - | ESPN+ | Bramlage Coliseum · Manhattan, KS |
| 5 | Thu Nov 20 | vsMississippi St | W98-77 | 5-0 | 1.000 | - | Peacock | Bramlage Coliseum · Manhattan, KS |
| 6 | Fri Nov 21 | atNebraska | L85-86 | 5-1 | .833 | - | Peacock | Pinnacle Bank Arena · Lincoln, NE |
| 7 | Tue Nov 25 | at25Indiana | L69-86 | 5-2 | .714 | - | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 8 | Mon Dec 1 | vsBowling Green | L66-82 | 5-3 | .625 | - | ESPN+ | Bramlage Coliseum · Manhattan, KS |
| 9 | Sat Dec 6 | vsSeton Hall | L67-78 | 5-4 | .556 | - | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 10 | Mon Dec 8 | vsMiss Valley St | W108-49 | 6-4 | .600 | - | ESPN+ | Bramlage Coliseum · Manhattan, KS |
| 11 | Sat Dec 13 | atCreighton | W83-76 | 7-4 | .636 | - | FOX | CHI Health Center Omaha · Omaha, NE |
| 12 | Sat Dec 20 | vsSouth Dakota | W106-76 | 8-4 | .667 | - | ESPN+ | Bramlage Coliseum · Manhattan, KS |
| 13 | Sun Dec 28 | vsUL Monroe | W94-85 | 9-4 | .692 | - | ESPN+ | Bramlage Coliseum · Manhattan, KS |
| 14 | Sat Jan 3 | vs10BYU | L73-83 | 9-5 | .643 | - | CBS | Bramlage Coliseum · Manhattan, KS |
| 15 | Wed Jan 7 | at1Arizona | L76-101 | 9-6 | .600 | - | FS1 | McKale Center · Tucson, AZ |
| 16 | Sat Jan 10 | atArizona St | L84-87 | 9-7 | .563 | - | Peacock | Desert Financial Arena · Tempe, AZ |
| 17 | Wed Jan 14 | vsUCF | L73-82 | 9-8 | .529 | - | Peacock | Bramlage Coliseum · Manhattan, KS |
| 18 | Sat Jan 17 | atOklahoma St | L83-84 | 9-9 | .500 | - | CBSSN | Gallagher-Iba Arena · Stillwater, OK |
| 19 | Tue Jan 20 | vsUtah | W81-78 | 10-9 | .526 | - | CBSSN | Bramlage Coliseum · Manhattan, KS |
| 20 | Sat Jan 24 | vs19Kansas | L62-86 | 10-10 | .500 | - | FOX | Bramlage Coliseum · Manhattan, KS |
| 21 | Tue Jan 27 | atWest Virginia | L54-59 | 10-11 | .476 | - | FS1 | WVU Coliseum · Morgantown, WV |
| 22 | Sun Feb 1 | vs8Iowa State | L61-95 | 10-12 | .455 | - | FOX | Bramlage Coliseum · Manhattan, KS |
| 23 | Sat Feb 7 | atTCU | L82-84 | 10-13 | .435 | - | TNT | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 24 | Wed Feb 11 | vsCincinnati | L62-91 | 10-14 | .417 | - | CBSSN | Bramlage Coliseum · Manhattan, KS |
| 25 | Sat Feb 14 | at3Houston | L64-78 | 10-15 | .400 | - | Peacock | Fertitta Center · Houston, TX |
| 26 | Tue Feb 17 | vsBaylor | W90-74 | 11-15 | .423 | - | ESPN2 | Bramlage Coliseum · Manhattan, KS |
| 27 | Sat Feb 21 | at13Texas Tech | L72-100 | 11-16 | .407 | - | FOX | United Supermarkets Arena · Lubbock, TX |
| 28 | Wed Feb 25 | atColorado | L70-79 | 11-17 | .393 | - | FS1 | CU Events Center · Boulder, CO |
| 29 | Sat Feb 28 | vsTCU | L68-77 | 11-18 | .379 | - | ESPN2 | Bramlage Coliseum · Manhattan, KS |
