| 1 | Tue Nov 5 | vs N Dakota St | W67-54 | 1-0 | 1.000 | - | | Bramlage Coliseum · Manhattan, KS |
| 2 | Sat Nov 9 | atUNLV | W60-56 (OT) | 2-0 | 1.000 | - | | Thomas & Mack Center · Las Vegas, NV |
| 3 | Wed Nov 13 | vsMonmouth | W73-54 | 3-0 | 1.000 | - | | Bramlage Coliseum · Manhattan, KS |
| 4 | Tue Nov 19 | vsAR-Pine Bluff | W62-51 | 4-0 | 1.000 | - | | Bramlage Coliseum · Manhattan, KS |
| 5 | Mon Nov 25 | vsPitt | L59-63 | 4-1 | .800 | - | FS1 | Bramlage Coliseum · Manhattan, KS |
| 6 | Wed Nov 27 | vsBradley | L60-73 | 4-2 | .667 | - | | Bramlage Coliseum · Manhattan, KS |
| 7 | Mon Dec 2 | vsFAMU | W76-58 | 5-2 | .714 | - | | Bramlage Coliseum · Manhattan, KS |
| 8 | Sat Dec 7 | vsMarquette | L65-73 | 5-3 | .625 | - | ESPN2 | Bramlage Coliseum · Manhattan, KS |
| 9 | Wed Dec 11 | vsAlabama St | W86-41 | 6-3 | .667 | - | | Bramlage Coliseum · Manhattan, KS |
| 10 | Sat Dec 14 | vsMississippi St | L61-67 | 6-4 | .600 | - | ESPNU | Prudential Center · Newark, NJ |
| 11 | Sat Dec 21 | vsSaint Louis | L63-66 | 6-5 | .545 | - | | T-Mobile Center · Kansas City, MOS |
| 12 | Sun Dec 29 | vsTulsa | W69-67 | 7-5 | .583 | - | | Bramlage Coliseum · Manhattan, KS |
| 13 | Sat Jan 4 | atOklahoma | L61-66 | 7-6 | .538 | - | | Lloyd Noble Center · Norman, OK |
| 14 | Tue Jan 7 | vsTCU | L57-59 | 7-7 | .500 | - | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 15 | Sat Jan 11 | atTexas | L50-64 | 7-8 | .467 | - | LHN | Moody Center · Austin, TX |
| 16 | Tue Jan 14 | vs23Texas Tech | L63-77 | 7-9 | .438 | - | | Bramlage Coliseum · Manhattan, KS |
| 17 | Sat Jan 18 | vs12West Virginia | W84-68 | 8-9 | .471 | - | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 18 | Tue Jan 21 | at3Kansas | L60-81 | 8-10 | .444 | - | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 19 | Sat Jan 25 | atAlabama | L74-77 | 8-11 | .421 | - | ESPN2 | Coleman Coliseum · Tuscaloosa, AL |
| 20 | Wed Jan 29 | vsOklahoma | W61-53 | 9-11 | .450 | - | | Bramlage Coliseum · Manhattan, KS |
| 21 | Sat Feb 1 | at12West Virginia | L57-66 | 9-12 | .429 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 22 | Mon Feb 3 | vs1Baylor | L67-73 | 9-13 | .409 | - | ESPN2 | Bramlage Coliseum · Manhattan, KS |
| 23 | Sat Feb 8 | atIowa State | L63-73 | 9-14 | .391 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 24 | Tue Feb 11 | vsOklahoma St | L59-64 | 9-15 | .375 | - | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 25 | Sat Feb 15 | atTCU | L57-68 | 9-16 | .360 | - | | Schollmaier Arena · Fort Worth, TX |
| 26 | Wed Feb 19 | atTexas Tech | L62-69 | 9-17 | .346 | - | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 27 | Sat Feb 22 | vsTexas | L59-70 | 9-18 | .333 | - | CBS | Bramlage Coliseum · Manhattan, KS |
| 28 | Tue Feb 25 | at2Baylor | L66-85 | 9-19 | .321 | - | | Ferrell Center · Waco, TX |
| 29 | Sat Feb 29 | vs1Kansas | L58-62 | 9-20 | .310 | - | CBS | Bramlage Coliseum · Manhattan, KS |
| 30 | Wed Mar 4 | atOklahoma St | L63-69 | 9-21 | .300 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 31 | Sat Mar 7 | vsIowa State | W79-63 | 10-21 | .323 | - | | Bramlage Coliseum · Manhattan, KS |
| 32 | Wed Mar 11 | atTCU | W53-49 | 11-21 | .344 | - | ESPNU | T-Mobile Center · Kansas City, MOS |
