| 1 | Mon Nov 6 | at #21USC | L69-82 | 0-1 | .000 | - | TNT | Galen Center · Los Angeles, CA |
| 2 | Fri Nov 10 | vs Bellarmine | W83-75 | 1-1 | .500 | - | | Bramlage Coliseum · Manhattan, KS |
| 3 | Mon Nov 13 | vs S Dakota St | W91-68 | 2-1 | .667 | - | | Bramlage Coliseum · Manhattan, KS |
| 4 | Fri Nov 17 | vs Providence | W73-70 (OT) | 3-1 | .750 | - | CBS | Bramlage Coliseum · Manhattan, KS |
| 5 | Sun Nov 19 | at #12Miami | L83-91 | 3-2 | .600 | - | CBS | Watsco Center · Coral Gables, FL |
| 6 | Wed Nov 22 | vs C Arkansas | W100-56 | 4-2 | .667 | - | | Bramlage Coliseum · Manhattan, KS |
| 7 | Tue Nov 28 | vs Oral Roberts | W88-78 (OT) | 5-2 | .714 | - | | Bramlage Coliseum · Manhattan, KS |
| 8 | Sat Dec 2 | vs North Alabama | W75-74 (OT) | 6-2 | .750 | - | | Bramlage Coliseum · Manhattan, KS |
| 9 | Tue Dec 5 | vs Villanova | W72-71 (OT) | 7-2 | .778 | - | ESPN2 | Bramlage Coliseum · Manhattan, KS |
| 10 | Sat Dec 9 | at LSU | W75-60 | 8-2 | .800 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 11 | Sun Dec 17 | vs Nebraska | L46-62 | 8-3 | .727 | - | | Bramlage Coliseum · Manhattan, KS |
| 12 | Thu Dec 21 | vs Wichita St | W69-60 | 9-3 | .750 | - | | Bramlage Coliseum · Manhattan, KS |
| 13 | Tue Jan 2 | vs Chicago St | W62-55 | 10-3 | .769 | - | | Bramlage Coliseum · Manhattan, KS |
| 14 | Sat Jan 6 | vs UCF | W77-52 | 11-3 | .786 | - | ESPN2 | Bramlage Coliseum · Manhattan, KS |
| 15 | Tue Jan 9 | at West Virginia | W81-67 | 12-3 | .800 | - | | WVU Coliseum · Morgantown, WV |
| 16 | Sat Jan 13 | at Texas Tech | L59-60 | 12-4 | .750 | - | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 17 | Tue Jan 16 | vs #9Baylor | W68-64 (OT) | 13-4 | .765 | - | | Bramlage Coliseum · Manhattan, KS |
| 18 | Sat Jan 20 | vs Oklahoma St | W70-66 | 14-4 | .778 | - | | Bramlage Coliseum · Manhattan, KS |
| 19 | Wed Jan 24 | at #23Iowa State | L67-78 | 14-5 | .737 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 20 | Sat Jan 27 | at #4Houston | L52-74 | 14-6 | .700 | - | ESPN | Fertitta Center · Houston, TX |
| 21 | Tue Jan 30 | vs #23Oklahoma | L53-73 | 14-7 | .667 | - | | Bramlage Coliseum · Manhattan, KS |
| 22 | Sat Feb 3 | atOklahoma St | L72-75 | 14-8 | .636 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 23 | Mon Feb 5 | vs #4Kansas | W75-70 (OT) | 15-8 | .652 | - | ESPN | Bramlage Coliseum · Manhattan, KS |
| 24 | Sat Feb 10 | at #21BYU | L66-72 | 15-9 | .625 | - | ESPN2 | Marriott Center · Provo, UT |
| 25 | Sat Feb 17 | vs TCU | L72-75 | 15-10 | .600 | - | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 26 | Mon Feb 19 | at Texas | L56-62 | 15-11 | .577 | - | ESPN2 | Moody Center · Austin, TX |
| 27 | Sat Feb 24 | vs#25BYU | W84-74 | 16-11 | .593 | - | | Bramlage Coliseum · Manhattan, KS |
| 28 | Mon Feb 26 | vsWest Virginia | W94-90 (OT) | 17-11 | .607 | - | ESPN2 | Bramlage Coliseum · Manhattan, KS |
| 29 | Sat Mar 2 | at Cincinnati | L72-74 | 17-12 | .586 | - | | Fifth Third Arena · Cincinnati, OH |
| 30 | Tue Mar 5 | at#14Kansas | L68-90 | 17-13 | .567 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 31 | Sat Mar 9 | vs#6Iowa State | W65-58 | 18-13 | .581 | - | ESPN2 | Bramlage Coliseum · Manhattan, KS |
| 32 | Wed Mar 13 | atTexas | W78-74 | 19-13 | .594 | - | | Moody Center · Austin, TX |
| 33 | Thu Mar 14 | at#7Iowa State | L57-76 | 19-14 | .576 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 34 | Tue Mar 19 | at Iowa | L82-91 | 19-15 | .559 | - | ESPN | Carver-Hawkeye Arena · Iowa City, IA |
