| 1 | Wed Oct 11 | vs Jets | W5-3 | 1-0-0 | 2 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 2 | Sat Oct 14 | atPenguins | L2-5 | 1-1-0 | 2 PTS | PPG Paints Arena · Pittsburgh, PA |
| 3 | Mon Oct 16 | atCapitals | L2-3 (SO) | 1-1-1 | 3 PTS | Capital One Arena · Washington, D.C. |
| 4 | Thu Oct 19 | atSabres | W4-3 | 2-1-1 | 5 PTS | KeyBank Center · Buffalo, NY |
| 5 | Fri Oct 20 | atJackets | L1-3 | 2-2-1 | 5 PTS | Nationwide Arena · Columbus, OH |
| 6 | Sun Oct 22 | atRed Wings | L2-6 | 2-3-1 | 5 PTS | Little Caesars Arena · Detroit, MI |
| 7 | Tue Oct 24 | vsRangers | L1-3 | 2-4-1 | 5 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 8 | Thu Oct 26 | vsBlues | L0-3 | 2-5-1 | 5 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 9 | Sun Oct 29 | atOilers | L2-5 | 2-6-1 | 5 PTS | Rogers Place · Edmonton, AB |
| 10 | Wed Nov 1 | vsStars | L3-4 | 2-7-1 | 5 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 11 | Sat Nov 4 | atKraken | W6-3 | 3-7-1 | 7 PTS | Climate Pledge Arena · Seattle, WA |
| 12 | Tue Nov 7 | vsPredators | W4-2 | 4-7-1 | 9 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 13 | Fri Nov 10 | atMaple Leafs | L4-5 (SO) | 4-7-2 | 10 PTS | Scotiabank Arena · Toronto, ON |
| 14 | Sat Nov 11 | atSenators | L1-4 | 4-8-2 | 10 PTS | Canadian Tire Centre · Ottawa, ON |
| 15 | Tue Nov 14 | atCanadiens | W2-1 | 5-8-2 | 12 PTS | Bell Centre · Montreal, QC |
| 16 | Thu Nov 16 | vsCanucks | W5-2 | 6-8-2 | 14 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 17 | Sat Nov 18 | vsIslanders | L4-5 (SO) | 6-8-3 | 15 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 18 | Mon Nov 20 | atKraken | W4-3 (OT) | 7-8-3 | 17 PTS | Climate Pledge Arena · Seattle, WA |
| 19 | Wed Nov 22 | atPredators | L2-4 | 7-9-3 | 17 PTS | Bridgestone Arena · Nashville, TN |
| 20 | Fri Nov 24 | atStars | W7-4 | 8-9-3 | 19 PTS | American Airlines Center · Dallas, TX |
| 21 | Sat Nov 25 | atAvalanche | L1-3 | 8-10-3 | 19 PTS | Ball Arena · Denver, CO |
| 22 | Mon Nov 27 | vsKnights | W2-1 (OT) | 9-10-3 | 21 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 23 | Thu Nov 30 | vsStars | W4-3 (OT) | 10-10-3 | 23 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 24 | Sat Dec 2 | vsCanucks | L3-4 | 10-11-3 | 23 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 25 | Tue Dec 5 | vsWild | L2-5 | 10-12-3 | 23 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 26 | Thu Dec 7 | vsHurricanes | W3-2 | 11-12-3 | 25 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 27 | Sat Dec 9 | vsDevils | L2-4 | 11-13-3 | 25 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 28 | Mon Dec 11 | atAvalanche | L5-6 | 11-14-3 | 25 PTS | Ball Arena · Denver, CO |
| 29 | Tue Dec 12 | atKnights | L4-5 (OT) | 11-14-4 | 26 PTS | T-Mobile Arena · Las Vegas, NV |
| 30 | Thu Dec 14 | atWild | L2-3 (SO) | 11-14-5 | 27 PTS | Xcel Energy Center · St. Paul, MN |
| 31 | Sat Dec 16 | vsLightning | W4-2 | 12-14-5 | 29 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 32 | Mon Dec 18 | vsPanthers | W3-1 | 13-14-5 | 31 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 33 | Thu Dec 21 | atDucks | W3-0 | 14-14-5 | 33 PTS | Honda Center · Anaheim, CA |
| 34 | Sat Dec 23 | atKings | L3-5 | 14-15-5 | 33 PTS | Crypto.com Arena · Los Angeles, CA |
| 35 | Wed Dec 27 | vsKraken | L1-2 | 14-16-5 | 33 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 36 | Sun Dec 31 | vsFlyers | W4-3 | 15-16-5 | 35 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 37 | Tue Jan 2 | atWild | W3-1 | 16-16-5 | 37 PTS | Xcel Energy Center · St. Paul, MN |
| 38 | Thu Jan 4 | atPredators | W6-3 | 17-16-5 | 39 PTS | Bridgestone Arena · Nashville, TN |
| 39 | Sat Jan 6 | atFlyers | L2-3 | 17-17-5 | 39 PTS | Wells Fargo Center · Philadelphia, PA |
| 40 | Sun Jan 7 | atBlackhawks | L3-4 | 17-18-5 | 39 PTS | United Center · Chicago, IL |
| 41 | Tue Jan 9 | vsSenators | W6-3 | 18-18-5 | 41 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 42 | Thu Jan 11 | atCoyotes | W6-2 | 19-18-5 | 43 PTS | Mullett Arena · Tempe, AZ |
| 43 | Sat Jan 13 | atKnights | W3-1 | 20-18-5 | 45 PTS | T-Mobile Arena · Las Vegas, NV |
| 44 | Tue Jan 16 | vsCoyotes | W3-2 (OT) | 21-18-5 | 47 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 45 | Thu Jan 18 | vsMaple Leafs | L3-4 | 21-19-5 | 47 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 46 | Sat Jan 20 | vsOilers | L1-3 | 21-20-5 | 47 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 47 | Tue Jan 23 | vsBlues | L3-4 | 21-21-5 | 47 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 48 | Thu Jan 25 | vsJackets | L2-5 | 21-22-5 | 47 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 49 | Sat Jan 27 | vsBlackhawks | W1-0 | 22-22-5 | 49 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 50 | Tue Feb 6 | atBruins | W4-1 | 23-22-5 | 51 PTS | TD Garden · Boston, MA |
| 51 | Thu Feb 8 | atDevils | W5-3 | 24-22-5 | 53 PTS | Prudential Center · Newark, NJ |
| 52 | Sat Feb 10 | atIslanders | W5-2 | 25-22-5 | 55 PTS | UBS Arena · Elmont, NY |
| 53 | Mon Feb 12 | atRangers | L0-2 | 25-23-5 | 55 PTS | Madison Square Garden · Manhattan, NY |
| 54 | Thu Feb 15 | vsSharks | L3-6 | 25-24-5 | 55 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 55 | Sat Feb 17 | vsRed Wings | L0-5 | 25-25-5 | 55 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 56 | Mon Feb 19 | vsJets | W6-3 | 26-25-5 | 57 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 57 | Thu Feb 22 | vsBruins | W3-2 (OT) | 27-25-5 | 59 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 58 | Sat Feb 24 | atOilers | W6-3 | 28-25-5 | 61 PTS | Rogers Place · Edmonton, AB |
| 59 | Tue Feb 27 | vsKings | W4-2 | 29-25-5 | 63 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 60 | Sat Mar 2 | vsPenguins | W4-3 | 30-25-5 | 65 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 61 | Mon Mar 4 | vsKraken | L2-4 | 30-26-5 | 65 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 62 | Thu Mar 7 | atLightning | W6-3 | 31-26-5 | 67 PTS | AMALIE Arena · Tampa, FL |
| 63 | Sat Mar 9 | atPanthers | L1-5 | 31-27-5 | 67 PTS | Amerant Bank Arena · Sunrise, FL |
| 64 | Sun Mar 10 | atHurricanes | L2-7 | 31-28-5 | 67 PTS | PNC Arena · Raleigh, NC |
| 65 | Tue Mar 12 | vsAvalanche | L2-6 | 31-29-5 | 67 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 66 | Thu Mar 14 | vsKnights | W4-1 | 32-29-5 | 69 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 67 | Sat Mar 16 | vsCanadiens | W5-2 | 33-29-5 | 71 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 68 | Mon Mar 18 | vsCapitals | L2-5 | 33-30-5 | 71 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 69 | Sat Mar 23 | atCanucks | L2-4 | 33-31-5 | 71 PTS | Rogers Arena · Vancouver, British Columbia |
| 70 | Sun Mar 24 | vsSabres | L1-4 | 33-32-5 | 71 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 71 | Tue Mar 26 | atBlackhawks | L1-3 | 33-33-5 | 71 PTS | United Center · Chicago, IL |
| 72 | Thu Mar 28 | atBlues | L3-5 | 33-34-5 | 71 PTS | Enterprise Center · St. Louis, MO |
| 73 | Sat Mar 30 | vsKings | W4-2 | 34-34-5 | 73 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 74 | Tue Apr 2 | vsDucks | L3-5 | 34-35-5 | 73 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 75 | Thu Apr 4 | atJets | L2-5 | 34-36-5 | 73 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 76 | Sat Apr 6 | vsOilers | L2-4 | 34-37-5 | 73 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 77 | Tue Apr 9 | atSharks | W3-2 (OT) | 35-37-5 | 75 PTS | SAP Center · San Jose, CA |
| 78 | Thu Apr 11 | atKings | L1-4 | 35-38-5 | 75 PTS | Crypto.com Arena · Los Angeles, CA |
| 79 | Fri Apr 12 | atDucks | W6-3 | 36-38-5 | 77 PTS | Honda Center · Anaheim, CA |
| 80 | Sun Apr 14 | vsCoyotes | W6-5 | 37-38-5 | 79 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 81 | Tue Apr 16 | atCanucks | L1-4 | 37-39-5 | 79 PTS | Rogers Arena · Vancouver, British Columbia |
| 82 | Thu Apr 18 | vsSharks | W5-1 | 38-39-5 | 81 PTS | Scotiabank Saddledome · Calgary, Alberta |
