| 1 | Wed Oct 9 | at Canucks | W6-5 (OT) | 1-0-0 | 2 PTS | Rogers Arena · Vancouver, British Columbia |
| 2 | Sat Oct 12 | vs Flyers | W6-3 | 2-0-0 | 4 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 3 | Sun Oct 13 | at Oilers | W4-1 | 3-0-0 | 6 PTS | Rogers Place · Edmonton, AB |
| 4 | Tue Oct 15 | vs Blackhawks | W3-1 | 4-0-0 | 8 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 5 | Sat Oct 19 | at Kraken | L1-2 (OT) | 4-0-1 | 9 PTS | Climate Pledge Arena · Seattle, WA |
| 6 | Tue Oct 22 | vs Penguins | W4-3 (SO) | 5-0-1 | 11 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 7 | Thu Oct 24 | vs Hurricanes | L2-4 | 5-1-1 | 11 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 8 | Sat Oct 26 | vs Jets | L3-5 | 5-2-1 | 11 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 9 | Mon Oct 28 | at Knights | L0-5 | 5-3-1 | 11 PTS | T-Mobile Arena · Las Vegas, NV |
| 10 | Wed Oct 30 | at Utah HC | L1-5 | 5-4-1 | 11 PTS | Delta Center · Salt Lake City, UT |
| 11 | Fri Nov 1 | vs Devils | W3-0 | 6-4-1 | 13 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 12 | Sun Nov 3 | vsOilers | L2-4 | 6-5-1 | 13 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 13 | Tue Nov 5 | at Canadiens | W3-2 (OT) | 7-5-1 | 15 PTS | Bell Centre · Montreal, QC |
| 14 | Thu Nov 7 | at Bruins | L3-4 (OT) | 7-5-2 | 16 PTS | TD Garden · Boston, MA |
| 15 | Sat Nov 9 | at Sabres | L2-3 (SO) | 7-5-3 | 17 PTS | KeyBank Center · Buffalo, NY |
| 16 | Mon Nov 11 | vs Kings | W3-1 | 8-5-3 | 19 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 17 | Tue Nov 12 | atCanucks | L1-3 | 8-6-3 | 19 PTS | Rogers Arena · Vancouver, British Columbia |
| 18 | Fri Nov 15 | vs Predators | W2-0 | 9-6-3 | 21 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 19 | Tue Nov 19 | vs Islanders | W2-1 (SO) | 10-6-3 | 23 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 20 | Thu Nov 21 | vs Rangers | W3-2 | 11-6-3 | 25 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 21 | Sat Nov 23 | vs Wild | W4-3 (SO) | 12-6-3 | 27 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 22 | Mon Nov 25 | at Senators | L3-4 | 12-7-3 | 27 PTS | Canadian Tire Centre · Ottawa, ON |
| 23 | Wed Nov 27 | at Red Wings | L1-2 (OT) | 12-7-4 | 28 PTS | Little Caesars Arena · Detroit, MI |
| 24 | Fri Nov 29 | at Jackets | L2-5 | 12-8-4 | 28 PTS | Nationwide Arena · Columbus, OH |
| 25 | Sat Nov 30 | atPenguins | L2-6 | 12-9-4 | 28 PTS | PPG Paints Arena · Pittsburgh, PA |
| 26 | Tue Dec 3 | vsJackets | W3-0 | 13-9-4 | 30 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 27 | Thu Dec 5 | vs Blues | L3-4 (OT) | 13-9-5 | 31 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 28 | Sun Dec 8 | at Stars | L2-6 | 13-10-5 | 31 PTS | American Airlines Center · Dallas, TX |
| 29 | Tue Dec 10 | atPredators | W4-3 | 14-10-5 | 33 PTS | Bridgestone Arena · Nashville, TN |
| 30 | Thu Dec 12 | vs Lightning | L3-8 | 14-11-5 | 33 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 31 | Sat Dec 14 | vs Panthers | W3-0 | 15-11-5 | 35 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 32 | Tue Dec 17 | vsBruins | L3-4 (OT) | 15-11-6 | 36 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 33 | Thu Dec 19 | vsSenators | L2-3 (OT) | 15-11-7 | 37 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 34 | Sat Dec 21 | vsBlackhawks | W6-4 | 16-11-7 | 39 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 35 | Sat Dec 28 | at Sharks | W3-1 | 17-11-7 | 41 PTS | SAP Center · San Jose, CA |
| 36 | Sun Dec 29 | atKnights | L0-3 | 17-12-7 | 41 PTS | T-Mobile Arena · Las Vegas, NV |
| 37 | Tue Dec 31 | vsCanucks | W3-1 | 18-12-7 | 43 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 38 | Thu Jan 2 | vsUtah HC | L3-5 | 18-13-7 | 43 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 39 | Sat Jan 4 | vsPredators | L1-4 | 18-14-7 | 43 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 40 | Tue Jan 7 | at Ducks | W3-2 (OT) | 19-14-7 | 45 PTS | Honda Center · Anaheim, CA |
| 41 | Sat Jan 11 | vsKings | W2-1 | 20-14-7 | 47 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 42 | Mon Jan 13 | atBlackhawks | W5-2 | 21-14-7 | 49 PTS | United Center · Chicago, IL |
| 43 | Tue Jan 14 | atBlues | L1-2 | 21-15-7 | 49 PTS | Enterprise Center · St. Louis, MO |
| 44 | Thu Jan 16 | atBlues | L1-4 | 21-16-7 | 49 PTS | Enterprise Center · St. Louis, MO |
| 45 | Sat Jan 18 | atJets | W3-1 | 22-16-7 | 51 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 46 | Thu Jan 23 | vsSabres | W5-2 | 23-16-7 | 53 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 47 | Sat Jan 25 | atWild | W5-4 | 24-16-7 | 55 PTS | Xcel Energy Center · St. Paul, MN |
| 48 | Sun Jan 26 | atJets | L2-5 | 24-17-7 | 55 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 49 | Tue Jan 28 | vs Capitals | L1-3 | 24-18-7 | 55 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 50 | Thu Jan 30 | vsDucks | W4-1 | 25-18-7 | 57 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 51 | Sat Feb 1 | vsRed Wings | L1-3 | 25-19-7 | 57 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 52 | Sun Feb 2 | atKraken | W3-2 | 26-19-7 | 59 PTS | Climate Pledge Arena · Seattle, WA |
| 53 | Tue Feb 4 | vs Maple Leafs | L3-6 | 26-20-7 | 59 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 54 | Thu Feb 6 | vs Avalanche | L2-4 | 26-21-7 | 59 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 55 | Sat Feb 8 | vsKraken | L2-3 (OT) | 26-21-8 | 60 PTS | Scotiabank Saddledome · Calgary, Alberta |
