| 1 | Thu Mar 26 | at Reds | W3-0 | 1-0 | 1.000 | Great American Ball Park · Cincinnati, OH |
| 2 | Sat Mar 28 | at Reds | L5-6 (11) | 1-1 | .500 | Great American Ball Park · Cincinnati, OH |
| 3 | Sun Mar 29 | at Reds | L2-3 | 1-2 | .333 | Great American Ball Park · Cincinnati, OH |
| 4 | Mon Mar 30 | at Astros | L1-8 | 1-3 | .250 | Minute Maid Park · Houston, TX |
| 5 | Tue Mar 31 | at Astros | L2-9 | 1-4 | .200 | Minute Maid Park · Houston, TX |
| 6 | Wed Apr 1 | at Astros | L4-6 | 1-5 | .167 | Minute Maid Park · Houston, TX |
| 7 | Fri Apr 3 | vs Padres | W5-2 | 2-5 | .286 | Fenway Park · Boston, MA |
| 8 | Sat Apr 4 | vs Padres | L2-3 | 2-6 | .250 | Fenway Park · Boston, MA |
| 9 | Sun Apr 5 | vs Padres | L6-8 | 2-7 | .222 | Fenway Park · Boston, MA |
| 10 | Mon Apr 6 | vs Brewers | L6-8 | 2-8 | .200 | Fenway Park · Boston, MA |
| 11 | Tue Apr 7 | vs Brewers | W3-2 | 3-8 | .273 | Fenway Park · Boston, MA |
| 12 | Wed Apr 8 | vs Brewers | W5-0 | 4-8 | .333 | Fenway Park · Boston, MA |
| 13 | Fri Apr 10 | at Cardinals | L2-3 | 4-9 | .308 | Busch Stadium · St. Louis, MO |
| 14 | Sat Apr 11 | at Cardinals | W7-1 | 5-9 | .357 | Busch Stadium · St. Louis, MO |
| 15 | Sun Apr 12 | at Cardinals | W9-3 | 6-9 | .400 | Busch Stadium · St. Louis, MO |
| 16 | Mon Apr 13 | at Twins | L6-13 | 6-10 | .375 | Target Field · Minneapolis, MN |
| 17 | Tue Apr 14 | at Twins | L0-6 | 6-11 | .353 | Target Field · Minneapolis, MN |
| 18 | Wed Apr 15 | at Twins | W9-5 | 7-11 | .389 | Target Field · Minneapolis, MN |
| 19 | Fri Apr 17 | vs Tigers | W1-0 (10) | 8-11 | .421 | Fenway Park · Boston, MA |
| 20 | Sat Apr 18 | vs Tigers | L1-4 | 8-12 | .400 | Fenway Park · Boston, MA |
| 21 | Sun Apr 19 | vs Tigers | L2-6 | 8-13 | .381 | Fenway Park · Boston, MA |
| 22 | Mon Apr 20 | vs Tigers | W8-6 | 9-13 | .409 | Fenway Park · Boston, MA |
| 23 | Tue Apr 21 | vs Yankees | L0-4 | 9-14 | .391 | Fenway Park · Boston, MA |
| 24 | Wed Apr 22 | vs Yankees | L1-4 | 9-15 | .375 | Fenway Park · Boston, MA |
| 25 | Thu Apr 23 | vs Yankees | L2-4 | 9-16 | .360 | Fenway Park · Boston, MA |
| 26 | Fri Apr 24 | at Orioles | L3-10 | 9-17 | .346 | Camden Yards · Baltimore, MD |
| 27 | Sat Apr 25 | at Orioles | W17-1 | 10-17 | .370 | Camden Yards · Baltimore, MD |
| 28 | Sun Apr 26 | at Orioles | W5-3 | 11-17 | .393 | Camden Yards · Baltimore, MD |
| 29 | Mon Apr 27 | at Blue Jays | W5-0 | 12-17 | .414 | Rogers Centre · Toronto, ON |
| 30 | Tue Apr 28 | at Blue Jays | L0-3 | 12-18 | .400 | Rogers Centre · Toronto, ON |
| 31 | Wed Apr 29 | at Blue Jays | L1-8 | 12-19 | .387 | Rogers Centre · Toronto, ON |
| 32 | Fri May 1 | vs Astros | W3-1 | 13-19 | .406 | Fenway Park · Boston, MA |
| 33 | Sat May 2 | vs Astros | L3-6 | 13-20 | .394 | Fenway Park · Boston, MA |
| 34 | Sun May 3 | vs Astros | L1-3 (10) | 13-21 | .382 | Fenway Park · Boston, MA |
| 35 | Mon May 4 | at Tigers | W5-4 | 14-21 | .400 | Comerica Park · Detroit, MI |
| 36 | Tue May 5 | at Tigers | W10-3 | 15-21 | .417 | Comerica Park · Detroit, MI |
| 37 | Wed May 6 | at Tigers | W4-0 | 16-21 | .432 | Comerica Park · Detroit, MI |
| 38 | Thu May 7 | vs Rays | L4-8 | 16-22 | .421 | Fenway Park · Boston, MA |
| 39 | Fri May 8 | vs Rays | W2-0 | 17-22 | .436 | Fenway Park · Boston, MA |
| 40 | Sun May 10 | vs Rays | L1-4 | 17-23 | .425 | Fenway Park · Boston, MA |
| 41 | Tue May 12 | vs Phillies | L1-2 | 17-24 | .415 | Fenway Park · Boston, MA |
| 42 | Wed May 13 | vs Phillies | W3-1 | 18-24 | .429 | Fenway Park · Boston, MA |
| 43 | Thu May 14 | vs Phillies | L1-3 | 18-25 | .419 | Fenway Park · Boston, MA |
| 44 | Fri May 15 | at Braves | L2-3 (10) | 18-26 | .409 | Truist Park · Cumberland, GA |
| 45 | Sat May 16 | at Braves | W3-2 | 19-26 | .422 | Truist Park · Cumberland, GA |
| 46 | Sun May 17 | at Braves | L1-8 | 19-27 | .413 | Truist Park · Cumberland, GA |
| 47 | Mon May 18 | at Royals | W3-1 | 20-27 | .426 | Kauffman Stadium · Kansas City, MO |
| 48 | Tue May 19 | at Royals | W7-1 | 21-27 | .438 | Kauffman Stadium · Kansas City, MO |
| 49 | Wed May 20 | at Royals | W4-3 | 22-27 | .449 | Kauffman Stadium · Kansas City, MO |
| 50 | Fri May 22 | vs Twins | L6-8 | 22-28 | .440 | Fenway Park · Boston, MA |
| 51 | Sat May 23 | vs Twins | L2-4 | 22-29 | .431 | Fenway Park · Boston, MA |
| 52 | Sun May 24 | vs Twins | L5-6 | 22-30 | .423 | Fenway Park · Boston, MA |
| 53 | Tue May 26 | vs Braves | L6-7 | 22-31 | .415 | Fenway Park · Boston, MA |
| 54 | Wed May 27 | vs Braves | W8-0 | 23-31 | .426 | Fenway Park · Boston, MA |
| 55 | Thu May 28 | vs Braves | L2-10 | 23-32 | .418 | Fenway Park · Boston, MA |
| 56 | Fri May 29 | at Guardians | L3-4 | 23-33 | .411 | Progressive Field · Cleveland, OH |
| 57 | Sat May 30 | at Guardians | W9-1 | 24-33 | .421 | Progressive Field · Cleveland, OH |
| 58 | Sun May 31 | at Guardians | W9-4 | 25-33 | .431 | Progressive Field · Cleveland, OH |
| 59 | Tue Jun 2 | vs Orioles | L2-4 | 25-34 | .424 | Fenway Park · Boston, MA |
| 60 | Wed Jun 3 | vs Orioles | W8-1 | 26-34 | .433 | Fenway Park · Boston, MA |
| 61 | Thu Jun 4 | vs Orioles | L2-8 | 26-35 | .426 | Fenway Park · Boston, MA |
| 62 | Fri Jun 5 | at Yankees | W5-3 | 27-35 | .435 | Yankee Stadium · The Bronx, NY |
| 63 | Sun Jun 7 | at Yankees | L1-6 | 27-36 | .429 | Yankee Stadium · The Bronx, NY |
| 64 | Mon Jun 8 | at Rays | L1-3 | 27-37 | .422 | Tropicana Field · St. Petersburg, FL |
| 65 | Tue Jun 9 | at Rays | L3-4 | 27-38 | .415 | Tropicana Field · St. Petersburg, FL |
| 66 | Wed Jun 10 | at Rays | L5-7 | 27-39 | .409 | Tropicana Field · St. Petersburg, FL |
| 67 | Fri Jun 12 | vs Rangers | W10-1 | 28-39 | .418 | Fenway Park · Boston, MA |
| 68 | Sat Jun 13 | vs Rangers | W6-3 | 29-39 | .426 | Fenway Park · Boston, MA |
| 69 | Sun Jun 14 | vs Rangers | L4-6 | 29-40 | .420 | Fenway Park · Boston, MA |
| 70 | Tue Jun 16 | vs Blue Jays | L1-6 | 29-41 | .414 | Fenway Park · Boston, MA |
| 71 | Wed Jun 17 | vs Blue Jays | L0-3 | 29-42 | .408 | Fenway Park · Boston, MA |
| 72 | Thu Jun 18 | vs Blue Jays | L3-4 | 29-43 | .403 | Fenway Park · Boston, MA |
| 73 | Fri Jun 19 | at Mariners | W6-2 | 30-43 | .411 | T-Mobile Park · Seattle, WA |
| 74 | Sat Jun 20 | at Mariners | W5-1 | 31-43 | .419 | T-Mobile Park · Seattle, WA |
| 75 | Sun Jun 21 | at Mariners | L1-3 | 31-44 | .413 | T-Mobile Park · Seattle, WA |
| 76 | Mon Jun 22 | at Rockies | L2-3 | 31-45 | .408 | Coors Field · Denver, CO |
| 77 | Tue Jun 23 | at Rockies | W5-2 | 32-45 | .416 | Coors Field · Denver, CO |
| 78 | Wed Jun 24 | at Rockies | L6-8 | 32-46 | .410 | Coors Field · Denver, CO |
| 79 | Thu Jun 25 | vs Yankees | W6-3 | 33-46 | .418 | Fenway Park · Boston, MA |
| 80 | Fri Jun 26 | vs Yankees | W6-1 | 34-46 | .425 | Fenway Park · Boston, MA |
| 81 | Sat Jun 27 | vs Yankees | W4-1 | 35-46 | .432 | Fenway Park · Boston, MA |
| 82 | Sun Jun 28 | vs Yankees | W5-4 (10) | 36-46 | .439 | Fenway Park · Boston, MA |
| 83 | Mon Jun 29 | vs Nationals | W6-3 | 37-46 | .446 | Fenway Park · Boston, MA |
| 84 | Tue Jun 30 | vs Nationals | L1-8 | 37-47 | .440 | Fenway Park · Boston, MA |
| 85 | Wed Jul 1 | vs Nationals | L2-10 | 37-48 | .435 | Fenway Park · Boston, MA |
| 86 | Fri Jul 3 | at Angels | W5-2 | 38-48 | .442 | Angel Stadium · Anaheim, CA |
| 87 | Sat Jul 4 | at Angels | W8-1 | 39-48 | .448 | Angel Stadium · Anaheim, CA |
| 88 | Sun Jul 5 | at Angels | W7-5 | 40-48 | .455 | Angel Stadium · Anaheim, CA |
| 89 | Tue Jul 7 | at White Sox | W8-1 | 41-48 | .461 | Guaranteed Rate Field · Chicago, IL |
| 90 | Wed Jul 8 | at White Sox | W5-0 | 42-48 | .467 | Guaranteed Rate Field · Chicago, IL |
| 91 | Thu Jul 9 | at White Sox | W2-1 | 43-48 | .473 | Guaranteed Rate Field · Chicago, IL |
| 92 | Fri Jul 10 | at Mets | W6-2 | 44-48 | .478 | Citi Field · Queens, NY |
| 93 | Sat Jul 11 | at Mets | W4-0 | 45-48 | .484 | Citi Field · Queens, NY |
| 94 | Sun Jul 12 | at Mets | W3-2 (10) | 46-48 | .489 | Citi Field · Queens, NY |