| 72 | Thu Jun 18 | vs Blue Jays | 1:35 PM | 36-38 | .486 | Fenway Park · Boston, MA |
| 73 | Fri Jun 19 | at Mariners | 10:10 PM | 38-37 | .507 | T-Mobile Park · Seattle, WA |
| 74 | Sat Jun 20 | at Mariners | 10:10 PM | 38-37 | .507 | T-Mobile Park · Seattle, WA |
| 75 | Sun Jun 21 | at Mariners | 4:10 PM | 38-37 | .507 | T-Mobile Park · Seattle, WA |
| 76 | Mon Jun 22 | at Rockies | 8:40 PM | 28-47 | .373 | Coors Field · Denver, CO |
| 77 | Tue Jun 23 | at Rockies | 8:40 PM | 28-47 | .373 | Coors Field · Denver, CO |
| 78 | Wed Jun 24 | at Rockies | 3:10 PM | 28-47 | .373 | Coors Field · Denver, CO |
| 79 | Thu Jun 25 | vs Yankees | 7:10 PM | 45-27 | .625 | Fenway Park · Boston, MA |
| 80 | Fri Jun 26 | vs Yankees | 7:10 PM | 45-27 | .625 | Fenway Park · Boston, MA |
| 81 | Sat Jun 27 | vs Yankees | 1:10 PM | 45-27 | .625 | Fenway Park · Boston, MA |
| 82 | Sun Jun 28 | vs Yankees | 7:20 PM | 45-27 | .625 | Fenway Park · Boston, MA |
| 83 | Mon Jun 29 | vs Nationals | 7:10 PM | 39-36 | .520 | Fenway Park · Boston, MA |
| 84 | Tue Jun 30 | vs Nationals | 7:10 PM | 39-36 | .520 | Fenway Park · Boston, MA |
| 85 | Wed Jul 1 | vs Nationals | 1:35 PM | 39-36 | .520 | Fenway Park · Boston, MA |
| 86 | Fri Jul 3 | at Angels | 9:38 PM | 30-45 | .400 | Angel Stadium · Anaheim, CA |
| 87 | Sat Jul 4 | at Angels | 9:38 PM | 30-45 | .400 | Angel Stadium · Anaheim, CA |
| 88 | Sun Jul 5 | at Angels | 9:30 PM | 30-45 | .400 | Angel Stadium · Anaheim, CA |
| 89 | Tue Jul 7 | at White Sox | 7:40 PM | 38-34 | .528 | Guaranteed Rate Field · Chicago, IL |
| 90 | Wed Jul 8 | at White Sox | 7:40 PM | 38-34 | .528 | Guaranteed Rate Field · Chicago, IL |
| 91 | Thu Jul 9 | at White Sox | 2:10 PM | 38-34 | .528 | Guaranteed Rate Field · Chicago, IL |
| 92 | Fri Jul 10 | at Mets | 7:15 PM | 33-41 | .446 | Citi Field · Queens, NY |
| 93 | Sat Jul 11 | at Mets | 4:10 PM | 33-41 | .446 | Citi Field · Queens, NY |
| 94 | Sun Jul 12 | at Mets | 1:40 PM | 33-41 | .446 | Citi Field · Queens, NY |
| 95 | Fri Jul 17 | vs Rays | 1:35 PM | 41-30 | .577 | Fenway Park · Boston, MA |
| 96 | Fri Jul 17 | vs Rays | 7:10 PM | 41-30 | .577 | Fenway Park · Boston, MA |
| 97 | Sat Jul 18 | vs Rays | 4:10 PM | 41-30 | .577 | Fenway Park · Boston, MA |
| 98 | Sun Jul 19 | vs Rays | 1:35 PM | 41-30 | .577 | Fenway Park · Boston, MA |
| 99 | Mon Jul 20 | vs Orioles | 7:10 PM | 35-40 | .467 | Fenway Park · Boston, MA |
| 100 | Tue Jul 21 | vs Orioles | 7:10 PM | 35-40 | .467 | Fenway Park · Boston, MA |
| 101 | Wed Jul 22 | vs Orioles | 7:10 PM | 35-40 | .467 | Fenway Park · Boston, MA |
| 102 | Fri Jul 24 | vs Blue Jays | 7:15 PM | 36-38 | .486 | Fenway Park · Boston, MA |
| 103 | Sat Jul 25 | vs Blue Jays | 4:10 PM | 36-38 | .486 | Fenway Park · Boston, MA |
| 104 | Sun Jul 26 | vs Blue Jays | 1:35 PM | 36-38 | .486 | Fenway Park · Boston, MA |
| 105 | Mon Jul 27 | at Athletics | 9:40 PM | 36-38 | .486 | Sutter Health Park · West Sacramento, CA |
| 106 | Tue Jul 28 | at Athletics | 9:40 PM | 36-38 | .486 | Sutter Health Park · West Sacramento, CA |
| 107 | Wed Jul 29 | at Athletics | 9:40 PM | 36-38 | .486 | Sutter Health Park · West Sacramento, CA |
| 108 | Thu Jul 30 | at Athletics | 9:40 PM | 36-38 | .486 | Sutter Health Park · West Sacramento, CA |
| 109 | Fri Jul 31 | at Dodgers | 10:10 PM | 48-27 | .640 | Dodger Stadium · Los Angeles, CA |
| 110 | Sat Aug 1 | at Dodgers | 9:10 PM | 48-27 | .640 | Dodger Stadium · Los Angeles, CA |
| 111 | Sun Aug 2 | at Dodgers | 7:20 PM | 48-27 | .640 | Dodger Stadium · Los Angeles, CA |
| 112 | Tue Aug 4 | vs White Sox | 7:10 PM | 38-34 | .528 | Fenway Park · Boston, MA |
| 113 | Wed Aug 5 | vs White Sox | 7:10 PM | 38-34 | .528 | Fenway Park · Boston, MA |
| 114 | Thu Aug 6 | vs White Sox | 7:10 PM | 38-34 | .528 | Fenway Park · Boston, MA |
| 115 | Fri Aug 7 | vs Athletics | 7:10 PM | 36-38 | .486 | Fenway Park · Boston, MA |
| 116 | Sat Aug 8 | vs Athletics | 4:10 PM | 36-38 | .486 | Fenway Park · Boston, MA |
| 117 | Sun Aug 9 | vs Athletics | 1:35 PM | 36-38 | .486 | Fenway Park · Boston, MA |
| 118 | Mon Aug 10 | at Blue Jays | 7:07 PM | 36-38 | .486 | Rogers Centre · Toronto, ON |
| 119 | Tue Aug 11 | at Blue Jays | 7:07 PM | 36-38 | .486 | Rogers Centre · Toronto, ON |
| 120 | Wed Aug 12 | at Blue Jays | 7:07 PM | 36-38 | .486 | Rogers Centre · Toronto, ON |
| 121 | Thu Aug 13 | at Blue Jays | 3:07 PM | 36-38 | .486 | Rogers Centre · Toronto, ON |
| 122 | Fri Aug 14 | at Pirates | 6:40 PM | 38-37 | .507 | PNC Park · Pittsburgh, PA |
| 123 | Sat Aug 15 | at Pirates | 7:15 PM | 38-37 | .507 | PNC Park · Pittsburgh, PA |
| 124 | Sun Aug 16 | at Pirates | 1:35 PM | 38-37 | .507 | PNC Park · Pittsburgh, PA |
| 125 | Mon Aug 17 | vs D-backs | 7:10 PM | 38-36 | .514 | Fenway Park · Boston, MA |
| 126 | Tue Aug 18 | vs D-backs | 7:10 PM | 38-36 | .514 | Fenway Park · Boston, MA |
| 127 | Wed Aug 19 | vs D-backs | 4:10 PM | 38-36 | .514 | Fenway Park · Boston, MA |
| 128 | Fri Aug 21 | vs Giants | 7:10 PM | 31-43 | .419 | Fenway Park · Boston, MA |
| 129 | Sat Aug 22 | vs Giants | 7:15 PM | 31-43 | .419 | Fenway Park · Boston, MA |
| 130 | Sun Aug 23 | vs Giants | 3:10 PM | 31-43 | .419 | Fenway Park · Boston, MA |
| 131 | Mon Aug 24 | at Marlins | 6:40 PM | 37-38 | .493 | LoanDepot Park · Miami, FL |
| 132 | Tue Aug 25 | at Marlins | 6:40 PM | 37-38 | .493 | LoanDepot Park · Miami, FL |
| 133 | Wed Aug 26 | at Marlins | 6:40 PM | 37-38 | .493 | LoanDepot Park · Miami, FL |
| 134 | Fri Aug 28 | at Yankees | 7:05 PM | 45-27 | .625 | Yankee Stadium · The Bronx, NY |
| 135 | Sat Aug 29 | at Yankees | 1:05 PM | 45-27 | .625 | Yankee Stadium · The Bronx, NY |
| 136 | Sat Aug 29 | at Yankees | 7:15 PM | 45-27 | .625 | Yankee Stadium · The Bronx, NY |
| 137 | Sun Aug 30 | at Yankees | 1:35 PM | 45-27 | .625 | Yankee Stadium · The Bronx, NY |
| 138 | Mon Aug 31 | vs Mariners | 6:45 PM | 38-37 | .507 | Fenway Park · Boston, MA |
| 139 | Tue Sep 1 | vs Mariners | 6:45 PM | 38-37 | .507 | Fenway Park · Boston, MA |
| 140 | Wed Sep 2 | vs Mariners | 4:10 PM | 38-37 | .507 | Fenway Park · Boston, MA |
| 141 | Thu Sep 3 | at Orioles | 7:15 PM | 35-40 | .467 | Camden Yards · Baltimore, MD |
| 142 | Fri Sep 4 | at Orioles | 7:05 PM | 35-40 | .467 | Camden Yards · Baltimore, MD |
| 143 | Sat Sep 5 | at Orioles | 7:05 PM | 35-40 | .467 | Camden Yards · Baltimore, MD |
| 144 | Sun Sep 6 | at Orioles | 1:35 PM | 35-40 | .467 | Camden Yards · Baltimore, MD |
| 145 | Mon Sep 7 | vs Angels | 1:35 PM | 30-45 | .400 | Fenway Park · Boston, MA |
| 146 | Tue Sep 8 | vs Angels | 6:45 PM | 30-45 | .400 | Fenway Park · Boston, MA |
| 147 | Wed Sep 9 | vs Angels | 6:45 PM | 30-45 | .400 | Fenway Park · Boston, MA |
| 148 | Fri Sep 11 | vs Royals | 7:10 PM | 30-45 | .400 | Fenway Park · Boston, MA |
| 149 | Sat Sep 12 | vs Royals | 4:10 PM | 30-45 | .400 | Fenway Park · Boston, MA |
| 150 | Sun Sep 13 | vs Royals | 1:35 PM | 30-45 | .400 | Fenway Park · Boston, MA |
| 151 | Tue Sep 15 | at Rangers | 8:05 PM | 35-38 | .479 | Globe Life Field · Arlington, TX |
| 152 | Wed Sep 16 | at Rangers | 8:05 PM | 35-38 | .479 | Globe Life Field · Arlington, TX |
| 153 | Thu Sep 17 | at Rangers | 8:05 PM | 35-38 | .479 | Globe Life Field · Arlington, TX |
| 154 | Fri Sep 18 | at Rays | 7:10 PM | 41-30 | .577 | Tropicana Field · St. Petersburg, FL |
| 155 | Sat Sep 19 | at Rays | 4:10 PM | 41-30 | .577 | Tropicana Field · St. Petersburg, FL |
| 156 | Sun Sep 20 | at Rays | 1:40 PM | 41-30 | .577 | Tropicana Field · St. Petersburg, FL |
| 157 | Tue Sep 22 | vs Guardians | 6:45 PM | 39-35 | .527 | Fenway Park · Boston, MA |
| 158 | Wed Sep 23 | vs Guardians | 7:10 PM | 39-35 | .527 | Fenway Park · Boston, MA |
| 159 | Thu Sep 24 | vs Guardians | 6:45 PM | 39-35 | .527 | Fenway Park · Boston, MA |
| 160 | Fri Sep 25 | vs Cubs | 7:10 PM | 39-36 | .520 | Fenway Park · Boston, MA |
| 161 | Sat Sep 26 | vs Cubs | 7:15 PM | 39-36 | .520 | Fenway Park · Boston, MA |
| 162 | Sun Sep 27 | vs Cubs | 3:05 PM | 39-36 | .520 | Fenway Park · Boston, MA |