| 1 | Wed Mar 25 | at Giants | W7-0 | 1-0 | 1.000 | Oracle Park · San Francisco, CA |
| 2 | Fri Mar 27 | at Giants | W3-0 | 2-0 | 1.000 | Oracle Park · San Francisco, CA |
| 3 | Sat Mar 28 | at Giants | W3-1 | 3-0 | 1.000 | Oracle Park · San Francisco, CA |
| 4 | Mon Mar 30 | at Mariners | L1-2 | 3-1 | .750 | T-Mobile Park · Seattle, WA |
| 5 | Tue Mar 31 | at Mariners | W5-0 | 4-1 | .800 | T-Mobile Park · Seattle, WA |
| 6 | Wed Apr 1 | at Mariners | W5-3 | 5-1 | .833 | T-Mobile Park · Seattle, WA |
| 7 | Fri Apr 3 | vs Marlins | W8-2 | 6-1 | .857 | Yankee Stadium · The Bronx, NY |
| 8 | Sat Apr 4 | vs Marlins | W9-7 | 7-1 | .875 | Yankee Stadium · The Bronx, NY |
| 9 | Sun Apr 5 | vs Marlins | L6-7 | 7-2 | .778 | Yankee Stadium · The Bronx, NY |
| 10 | Tue Apr 7 | vs Athletics | W5-3 | 8-2 | .800 | Yankee Stadium · The Bronx, NY |
| 11 | Wed Apr 8 | vs Athletics | L2-3 | 8-3 | .727 | Yankee Stadium · The Bronx, NY |
| 12 | Thu Apr 9 | vs Athletics | L0-1 | 8-4 | .667 | Yankee Stadium · The Bronx, NY |
| 13 | Fri Apr 10 | at Rays | L3-5 | 8-5 | .615 | Tropicana Field · St. Petersburg, FL |
| 14 | Sat Apr 11 | at Rays | L4-5 (10) | 8-6 | .571 | Tropicana Field · St. Petersburg, FL |
| 15 | Sun Apr 12 | at Rays | L4-5 | 8-7 | .533 | Tropicana Field · St. Petersburg, FL |
| 16 | Mon Apr 13 | vs Angels | W11-10 | 9-7 | .563 | Yankee Stadium · The Bronx, NY |
| 17 | Tue Apr 14 | vs Angels | L1-7 | 9-8 | .529 | Yankee Stadium · The Bronx, NY |
| 18 | Wed Apr 15 | vs Angels | W5-4 | 10-8 | .556 | Yankee Stadium · The Bronx, NY |
| 19 | Thu Apr 16 | vs Angels | L4-11 | 10-9 | .526 | Yankee Stadium · The Bronx, NY |
| 20 | Fri Apr 17 | vs Royals | W4-2 | 11-9 | .550 | Yankee Stadium · The Bronx, NY |
| 21 | Sat Apr 18 | vs Royals | W13-4 | 12-9 | .571 | Yankee Stadium · The Bronx, NY |
| 22 | Sun Apr 19 | vs Royals | W7-0 | 13-9 | .591 | Yankee Stadium · The Bronx, NY |
| 23 | Tue Apr 21 | at Red Sox | W4-0 | 14-9 | .609 | Fenway Park · Boston, MA |
| 24 | Wed Apr 22 | at Red Sox | W4-1 | 15-9 | .625 | Fenway Park · Boston, MA |
| 25 | Thu Apr 23 | at Red Sox | W4-2 | 16-9 | .640 | Fenway Park · Boston, MA |
| 26 | Fri Apr 24 | at Astros | W12-4 | 17-9 | .654 | Minute Maid Park · Houston, TX |
| 27 | Sat Apr 25 | at Astros | W8-3 | 18-9 | .667 | Minute Maid Park · Houston, TX |
| 28 | Sun Apr 26 | at Astros | L4-7 | 18-10 | .643 | Minute Maid Park · Houston, TX |
| 29 | Mon Apr 27 | at Rangers | W4-2 | 19-10 | .655 | Globe Life Field · Arlington, TX |
| 30 | Tue Apr 28 | at Rangers | W3-2 | 20-10 | .667 | Globe Life Field · Arlington, TX |
| 31 | Wed Apr 29 | at Rangers | L0-3 | 20-11 | .645 | Globe Life Field · Arlington, TX |
| 32 | Fri May 1 | vs Orioles | W7-2 | 21-11 | .656 | Yankee Stadium · The Bronx, NY |
| 33 | Sat May 2 | vs Orioles | W9-4 | 22-11 | .667 | Yankee Stadium · The Bronx, NY |
| 34 | Sun May 3 | vs Orioles | W11-3 | 23-11 | .676 | Yankee Stadium · The Bronx, NY |
| 35 | Mon May 4 | vs Orioles | W12-1 | 24-11 | .686 | Yankee Stadium · The Bronx, NY |
| 36 | Tue May 5 | vs Rangers | W7-4 | 25-11 | .694 | Yankee Stadium · The Bronx, NY |
| 37 | Wed May 6 | vs Rangers | L1-6 | 25-12 | .676 | Yankee Stadium · The Bronx, NY |
| 38 | Thu May 7 | vs Rangers | W9-2 | 26-12 | .684 | Yankee Stadium · The Bronx, NY |
| 39 | Fri May 8 | at Brewers | L0-6 | 26-13 | .667 | American Family Field · Milwaukee, WI |
| 40 | Sat May 9 | at Brewers | L3-4 (10) | 26-14 | .650 | American Family Field · Milwaukee, WI |
| 41 | Sun May 10 | at Brewers | L3-4 | 26-15 | .634 | American Family Field · Milwaukee, WI |
| 42 | Mon May 11 | at Orioles | L2-3 | 26-16 | .619 | Camden Yards · Baltimore, MD |
| 43 | Tue May 12 | at Orioles | W6-2 | 27-16 | .628 | Camden Yards · Baltimore, MD |
| 44 | Wed May 13 | at Orioles | L0-7 | 27-17 | .614 | Camden Yards · Baltimore, MD |
| 45 | Fri May 15 | at Mets | W5-2 | 28-17 | .622 | Citi Field · Queens, NY |
| 46 | Sat May 16 | at Mets | L3-6 | 28-18 | .609 | Citi Field · Queens, NY |
| 47 | Sun May 17 | at Mets | L6-7 (10) | 28-19 | .596 | Citi Field · Queens, NY |
| 48 | Mon May 18 | vs Blue Jays | W7-6 | 29-19 | .604 | Yankee Stadium · The Bronx, NY |
| 49 | Tue May 19 | vs Blue Jays | W5-4 | 30-19 | .612 | Yankee Stadium · The Bronx, NY |
| 50 | Wed May 20 | vs Blue Jays | L1-2 | 30-20 | .600 | Yankee Stadium · The Bronx, NY |
| 51 | Thu May 21 | vs Blue Jays | L0-2 | 30-21 | .588 | Yankee Stadium · The Bronx, NY |
| 52 | Fri May 22 | vs Rays | L2-4 | 30-22 | .577 | Yankee Stadium · The Bronx, NY |
| 53 | Sun May 24 | vs Rays | W2-0 | 31-22 | .585 | Yankee Stadium · The Bronx, NY |
| 54 | Mon May 25 | at Royals | W4-3 | 32-22 | .593 | Kauffman Stadium · Kansas City, MO |
| 55 | Tue May 26 | at Royals | W15-1 | 33-22 | .600 | Kauffman Stadium · Kansas City, MO |
| 56 | Wed May 27 | at Royals | W7-0 | 34-22 | .607 | Kauffman Stadium · Kansas City, MO |
| 57 | Fri May 29 | at Athletics | W8-2 | 35-22 | .614 | Sutter Health Park · West Sacramento, CA |
| 58 | Sat May 30 | at Athletics | L4-6 | 35-23 | .603 | Sutter Health Park · West Sacramento, CA |
| 59 | Sun May 31 | at Athletics | W13-8 | 36-23 | .610 | Sutter Health Park · West Sacramento, CA |
| 60 | Tue Jun 2 | vs Guardians | L4-9 | 36-24 | .600 | Yankee Stadium · The Bronx, NY |
| 61 | Wed Jun 3 | vs Guardians | L4-5 | 36-25 | .590 | Yankee Stadium · The Bronx, NY |
| 62 | Thu Jun 4 | vs Guardians | W2-1 | 37-25 | .597 | Yankee Stadium · The Bronx, NY |
| 63 | Fri Jun 5 | vs Red Sox | L3-5 | 37-26 | .587 | Yankee Stadium · The Bronx, NY |
| 64 | Sun Jun 7 | vs Red Sox | W6-1 | 38-26 | .594 | Yankee Stadium · The Bronx, NY |
| 65 | Mon Jun 8 | at Guardians | W7-5 (10) | 39-26 | .600 | Progressive Field · Cleveland, OH |
| 66 | Tue Jun 9 | at Guardians | W3-2 | 40-26 | .606 | Progressive Field · Cleveland, OH |
| 67 | Wed Jun 10 | at Guardians | W8-4 | 41-26 | .612 | Progressive Field · Cleveland, OH |
| 68 | Fri Jun 12 | at Blue Jays | L5-8 | 41-27 | .603 | Rogers Centre · Toronto, ON |
| 69 | Sat Jun 13 | at Blue Jays | W3-1 | 42-27 | .609 | Rogers Centre · Toronto, ON |
| 70 | Sun Jun 14 | at Blue Jays | W8-3 | 43-27 | .614 | Rogers Centre · Toronto, ON |
| 71 | Tue Jun 16 | vs White Sox | W12-2 | 44-27 | .620 | Yankee Stadium · The Bronx, NY |
| 72 | Wed Jun 17 | vs White Sox | W10-5 | 45-27 | .625 | Yankee Stadium · The Bronx, NY |
| 73 | Thu Jun 18 | vs White Sox | L1-5 | 45-28 | .616 | Yankee Stadium · The Bronx, NY |
| 74 | Fri Jun 19 | vs Reds | W5-0 | 46-28 | .622 | Yankee Stadium · The Bronx, NY |
| 75 | Sat Jun 20 | vs Reds | L2-10 | 46-29 | .613 | Yankee Stadium · The Bronx, NY |
| 76 | Sun Jun 21 | vs Reds | L1-4 | 46-30 | .605 | Yankee Stadium · The Bronx, NY |
| 77 | Mon Jun 22 | at Tigers | L3-5 | 46-31 | .597 | Comerica Park · Detroit, MI |
| 78 | Tue Jun 23 | at Tigers | W4-3 | 47-31 | .603 | Comerica Park · Detroit, MI |
| 79 | Wed Jun 24 | at Tigers | W4-2 | 48-31 | .608 | Comerica Park · Detroit, MI |
| 80 | Thu Jun 25 | at Red Sox | L3-6 | 48-32 | .600 | Fenway Park · Boston, MA |
| 81 | Fri Jun 26 | at Red Sox | L1-6 | 48-33 | .593 | Fenway Park · Boston, MA |
| 82 | Sat Jun 27 | at Red Sox | L1-4 | 48-34 | .585 | Fenway Park · Boston, MA |
| 83 | Sun Jun 28 | at Red Sox | L4-5 (10) | 48-35 | .578 | Fenway Park · Boston, MA |
| 84 | Mon Jun 29 | vs Tigers | L3-7 | 48-36 | .571 | Yankee Stadium · The Bronx, NY |
| 85 | Tue Jun 30 | vs Tigers | L3-9 | 48-37 | .565 | Yankee Stadium · The Bronx, NY |
| 86 | Wed Jul 1 | vs Tigers | L2-6 (11) | 48-38 | .558 | Yankee Stadium · The Bronx, NY |
| 87 | Fri Jul 3 | vs Twins | W5-2 | 49-38 | .563 | Yankee Stadium · The Bronx, NY |
| 88 | Sat Jul 4 | vs Twins | L4-11 | 49-39 | .557 | Yankee Stadium · The Bronx, NY |
| 89 | Sun Jul 5 | vs Twins | L1-6 | 49-40 | .551 | Yankee Stadium · The Bronx, NY |
| 90 | Mon Jul 6 | at Rays | W5-1 | 50-40 | .556 | Tropicana Field · St. Petersburg, FL |
| 91 | Tue Jul 7 | at Rays | L4-6 | 50-41 | .549 | Tropicana Field · St. Petersburg, FL |
| 92 | Wed Jul 8 | at Rays | L0-3 | 50-42 | .543 | Tropicana Field · St. Petersburg, FL |
| 93 | Thu Jul 9 | at Rays | W12-4 | 51-42 | .548 | Tropicana Field · St. Petersburg, FL |
| 94 | Fri Jul 10 | at Nationals | W5-3 | 52-42 | .553 | Nationals Park · Washington, D.C. |
| 95 | Sat Jul 11 | at Nationals | W4-2 | 53-42 | .558 | Nationals Park · Washington, D.C. |
| 96 | Sun Jul 12 | at Nationals | W5-3 | 54-42 | .563 | Nationals Park · Washington, D.C. |