| 1 | Fri Nov 7 | at Kent State | L102-110 | 0-1 | .000 | - | ESPN+ | M.A.C. Center · Kent, OH |
| 2 | Sun Nov 9 | atIllinois St | L65-76 | 0-2 | .000 | - | ESPN+ | Redbird Arena · Normal, IL |
| 3 | Thu Nov 13 | atLafayette | W97-78 | 1-2 | .333 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 4 | Tue Nov 18 | vsArmy | W86-73 | 2-2 | .500 | - | ESPN+ | Newman Arena · Ithaca, NY |
| 5 | Thu Nov 20 | vsColgate | W95-94 (2OT) | 3-2 | .600 | - | ESPN+ | Newman Arena · Ithaca, NY |
| 6 | Wed Nov 26 | vsTBD | W114-70 | 4-2 | .667 | - | ESPN+ | Newman Arena · Ithaca, NY |
| 7 | Sun Nov 30 | atBucknell | W101-72 | 5-2 | .714 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 8 | Tue Dec 2 | atGeorge Mason | L81-99 | 5-3 | .625 | - | ESPN+ | EagleBank Arena · Fairfax, VA |
| 9 | Wed Dec 3 | atTowson | L80-93 | 5-4 | .556 | - | | SECU Arena · Towson, MD |
| 10 | Sun Dec 7 | atSamford | L90-93 | 5-5 | .500 | - | ESPN+ | Pete Hanna Center · Homewood, AL |
| 11 | Sun Dec 21 | atAlbany | W83-75 | 6-5 | .545 | - | ESPN+ | SEFCU Arena · Albany, NY |
| 12 | Mon Dec 29 | at9Michigan St | L97-114 | 6-6 | .500 | - | FS1 | Breslin Center · East Lansing, MI |
| 13 | Fri Jan 2 | vsTBD | W133-65 | 7-6 | .538 | - | ESPN+ | Newman Arena · Ithaca, NY |
| 14 | Mon Jan 5 | vsColumbia | L99-104 | 7-7 | .500 | - | ESPN+ | Newman Arena · Ithaca, NY |
| 15 | Sat Jan 10 | vsDartmouth | L91-102 | 7-8 | .467 | - | ESPN+ | Newman Arena · Ithaca, NY |
| 16 | Sat Jan 17 | atYale | L68-102 | 7-9 | .438 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 17 | Mon Jan 19 | atBrown | W89-67 | 8-9 | .471 | - | ESPN+ | Pizzitola Sports Center · Providence, RI |
| 18 | Sat Jan 24 | atHarvard | W86-79 | 9-9 | .500 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 19 | Fri Jan 30 | vsPrinceton | W87-64 | 10-9 | .526 | - | ESPN+ | Newman Arena · Ithaca, NY |
| 20 | Sat Jan 31 | vsPenn | L81-91 | 10-10 | .500 | - | ESPN+ | Newman Arena · Ithaca, NY |
| 21 | Sat Feb 7 | atColumbia | W88-67 | 11-10 | .524 | - | ESPN+ | Francis S. Levien Gymnasium · New York, NY |
| 22 | Fri Feb 13 | atPrinceton | W89-65 | 12-10 | .545 | - | ESPN+ | Jadwin Gymnasium · Princeton, NJ |
| 23 | Sat Feb 14 | atPenn | L76-82 | 12-11 | .522 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 24 | Sat Feb 21 | vsHarvard | L54-73 | 12-12 | .500 | - | ESPN+ | Newman Arena · Ithaca, NY |
| 25 | Fri Feb 27 | vsYale | W72-69 | 13-12 | .520 | - | ESPNU | Newman Arena · Ithaca, NY |
| 26 | Sat Feb 28 | vsBrown | W86-80 | 14-12 | .538 | - | ESPN+ | Newman Arena · Ithaca, NY |
