| 1 | Mon Nov 6 | at Lehigh | W84-78 | 1-0 | 1.000 | - | | Stabler Arena · Bethlehem, PA |
| 2 | Wed Nov 8 | vsTBD | W107-86 | 2-0 | 1.000 | - | | Newman Arena · Ithaca, NY |
| 3 | Sat Nov 11 | atFordham | W78-73 | 3-0 | 1.000 | - | | Rose Hill Gymnasium · Bronx, NY |
| 4 | Wed Nov 15 | atGeorge Mason | L83-90 | 3-1 | .750 | - | | EagleBank Arena · Fairfax, VA |
| 5 | Sun Nov 19 | atFullerton | W88-70 | 4-1 | .800 | - | | Titan Gym · Fullerton, CA |
| 6 | Mon Nov 20 | atUtah Valley | W74-61 | 5-1 | .833 | - | | UCCU Center · Orem, UT |
| 7 | Wed Nov 29 | vsMonmouth | W91-87 | 6-1 | .857 | - | | Newman Arena · Ithaca, NY |
| 8 | Sat Dec 2 | atLafayette | W79-71 | 7-1 | .875 | - | | Kirby Sports Center · Easton, PA |
| 9 | Tue Dec 5 | atSyracuse | L70-81 | 7-2 | .778 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 10 | Tue Dec 19 | atSiena | W95-74 | 8-2 | .800 | - | | MVP Arena · Albany, NY |
| 11 | Fri Dec 22 | atRobert Morris | W90-85 | 9-2 | .818 | - | | UPMC Events Center · Moon Township, PA |
| 12 | Sat Dec 30 | vsColgate | W77-64 | 10-2 | .833 | - | | Newman Arena · Ithaca, NY |
| 13 | Tue Jan 2 | at18Baylor | L79-98 | 10-3 | .769 | - | | Ferrell Center · Waco, TX |
| 14 | Tue Jan 9 | vsColumbia | W91-79 | 11-3 | .786 | - | | Newman Arena · Ithaca, NY |
| 15 | Mon Jan 15 | vsPenn | W77-60 | 12-3 | .800 | - | | Newman Arena · Ithaca, NY |
| 16 | Sat Jan 20 | atBrown | W84-83 | 13-3 | .813 | - | | Pizzitola Sports Center · Providence, RI |
| 17 | Tue Jan 23 | vsTBD | W105-49 | 14-3 | .824 | - | | Newman Arena · Ithaca, NY |
| 18 | Sat Jan 27 | vsPrinceton | W83-68 | 15-3 | .833 | - | | Newman Arena · Ithaca, NY |
| 19 | Fri Feb 2 | atDartmouth | W56-53 | 16-3 | .842 | - | | Edward Leede Arena · Hanover, NH |
| 20 | Sat Feb 3 | atHarvard | W89-76 | 17-3 | .850 | - | | Lavietes Pavilion · Cambridge, MA |
| 21 | Sat Feb 10 | atYale | L78-80 | 17-4 | .810 | - | | John J. Lee Amphitheater · New Haven, CT |
| 22 | Fri Feb 16 | vsHarvard | W75-62 | 18-4 | .818 | - | | Newman Arena · Ithaca, NY |
| 23 | Sat Feb 17 | vsDartmouth | W89-80 | 19-4 | .826 | - | | Newman Arena · Ithaca, NY |
| 24 | Fri Feb 23 | vsYale | W65-62 | 20-4 | .833 | - | | Newman Arena · Ithaca, NY |
| 25 | Sat Feb 24 | vsBrown | L74-78 | 20-5 | .800 | - | | Newman Arena · Ithaca, NY |
| 26 | Fri Mar 1 | atPenn | W87-81 | 21-5 | .808 | - | | The Palestra · Philadelphia, PA |
| 27 | Sat Mar 2 | atPrinceton | L77-79 | 21-6 | .778 | - | | Jadwin Gymnasium · Princeton, NJ |
| 28 | Sat Mar 9 | atColumbia | W98-76 | 22-6 | .786 | - | | Francis S. Levien Gymnasium · New York, NY |
| 29 | Sat Mar 16 | atYale | L57-69 | 22-7 | .759 | - | ESPNEWS | Francis S. Levien Gymnasium · New York, NY |
| 30 | Tue Mar 19 | atOhio State | L83-88 | 22-8 | .733 | - | ESPN2 | Value City Arena · Columbus, OH |
