| 1 | Wed Nov 25 | vs High Point | W82-73 | 1-0 | 1.000 | - | | John M. Belk Arena · Davidson, NC |
| 2 | Mon Nov 30 | vsTexas | L76-78 | 1-1 | .500 | - | ESPN2 | John M. Belk Arena · Davidson, NC |
| 3 | Tue Dec 1 | atProvidence | L62-63 | 1-2 | .333 | - | ESPN2 | Amica Mutual Pavilion · Providence, RI |
| 4 | Wed Dec 2 | atUNLV | W77-73 | 2-2 | .500 | - | ESPN2 | Thomas & Mack Center · Las Vegas, NV |
| 5 | Fri Dec 11 | vsGeorgia So | W77-45 | 3-2 | .600 | - | | John M. Belk Arena · Davidson, NC |
| 6 | Tue Dec 15 | vsCharlotte | L52-63 | 13-9 | .591 | - | | John M. Belk Arena · Davidson, NC |
| 7 | Fri Dec 18 | atRhode Island | W67-58 | 4-3 | .571 | - | ESPNU | Ryan Center · Kingston, RI |
| 8 | Tue Dec 22 | vsVanderbilt | W85-65 | 5-3 | .625 | - | | John M. Belk Arena · Davidson, NC |
| 9 | Wed Dec 30 | vsRichmond | L74-80 | 5-4 | .556 | - | CBSSN | John M. Belk Arena · Davidson, NC |
| 11 | Tue Jan 5 | atDuquesne | W61-48 | 6-4 | .600 | - | CBSSN | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 12 | Fri Jan 8 | vsDayton | L78-89 (OT) | 6-5 | .545 | - | ESPN2 | John M. Belk Arena · Davidson, NC |
| 13 | Tue Jan 12 | vsSaint Joseph's | W80-66 | 7-5 | .583 | - | | John M. Belk Arena · Davidson, NC |
| 15 | Sat Jan 16 | atLa Salle | W77-53 | 8-5 | .615 | - | | Tom Gola Arena · Philadelphia, PA |
| 16 | Wed Jan 20 | vsFordham | W73-58 | 9-5 | .643 | - | | John M. Belk Arena · Davidson, NC |
| 17 | Sun Jan 24 | atUMass | W69-60 | 10-5 | .667 | - | CBSSN | William D. Mullins Memorial Center · Amherst, MA |
| 20 | Fri Feb 19 | vsTBD | W101-51 | 11-5 | .688 | - | | John M. Belk Arena · Davidson, NC |
| 21 | Sun Feb 21 | atSt Bonaventure | L58-69 | 11-6 | .647 | - | | Reilly Center · Saint Bonaventure, NY |
| 22 | Wed Feb 24 | vsSt Bonaventure | L53-56 | 11-7 | .611 | - | | John M. Belk Arena · Davidson, NC |
| 23 | Sat Feb 27 | vsVCU | W65-57 | 12-7 | .632 | - | ESPNU | John M. Belk Arena · Davidson, NC |
| 24 | Fri Mar 5 | vsGeorge Mason | W99-67 | 13-7 | .650 | - | NBCSN | Robins Center · Richmond, VA |
| 25 | Sat Mar 6 | atVCU | L52-64 | 13-8 | .619 | - | CBSSN | Stuart C. Siegel Center · Richmond, VA |
| 22 | Thu Mar 18 | vs3NC State | L61-75 | 13-9 | .591 | #2 | ESPN | The Super Pit · Denton, TX |
