| 1 | Mon Nov 3 | vs TBD | W97-63 | 1-0 | 1.000 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 2 | Fri Nov 7 | vsWashington St | W85-69 | 2-0 | 1.000 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 3 | Tue Nov 11 | atCharlotte | W62-55 | 3-0 | 1.000 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 4 | Sat Nov 15 | vsBowling Green | W91-87 | 4-0 | 1.000 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 5 | Fri Nov 21 | atBoston College | W59-49 | 5-0 | 1.000 | - | ESPN2 | TD Arena · Charleston, SC |
| 6 | Sun Nov 23 | vsUtah State | L60-94 | 5-1 | .833 | - | ESPN2 | TD Arena · Charleston, SC |
| 7 | Fri Nov 28 | vsNC A&T | W90-74 | 6-1 | .857 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 8 | Thu Dec 4 | vsThe Citadel | W79-63 | 7-1 | .875 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 9 | Sun Dec 7 | vsSaint Mary's | L61-70 | 7-2 | .778 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 10 | Sat Dec 13 | vsMercyhurst | W80-47 | 8-2 | .800 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 11 | Thu Dec 18 | vsTemple | L63-68 | 8-3 | .727 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 12 | Mon Dec 22 | at17Kansas | L61-90 | 8-4 | .667 | - | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 13 | Tue Dec 30 | vsDuquesne | L83-89 (2OT) | 8-5 | .615 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 14 | Sat Jan 3 | atSaint Joseph's | W62-56 | 9-5 | .643 | - | CBSSN | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 15 | Wed Jan 7 | atLoyola Chicago | W79-64 | 10-5 | .667 | - | CBSSN | Joseph J. Gentile Arena · Chicago, IL |
| 16 | Sat Jan 10 | vsRhode Island | L45-70 | 10-6 | .625 | - | USA Net | John M. Belk Arena · Davidson, NC |
| 17 | Wed Jan 14 | atG Washington | W84-79 | 11-6 | .647 | - | ESPN+ | Charles E. Smith Center · Washington, D.C. |
| 18 | Wed Jan 21 | vsFordham | W68-63 | 12-6 | .667 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 19 | Sat Jan 24 | vsVCU | L69-75 | 12-7 | .632 | - | USA Net | John M. Belk Arena · Davidson, NC |
| 20 | Wed Jan 28 | atGeorge Mason | L52-60 | 12-8 | .600 | - | CBSSN | EagleBank Arena · Fairfax, VA |
| 21 | Sat Jan 31 | atRichmond | W79-54 | 13-8 | .619 | - | USA Net | Robins Center · Richmond, VA |
| 22 | Tue Feb 3 | vs19Saint Louis | L82-91 | 13-9 | .591 | - | CBSSN | John M. Belk Arena · Davidson, NC |
| 23 | Fri Feb 6 | vsLoyola Chicago | W84-64 | 14-9 | .609 | - | CBSSN | John M. Belk Arena · Davidson, NC |
| 24 | Mon Feb 9 | vsTBD | W114-53 | 15-9 | .625 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 25 | Sun Feb 15 | atDayton | L59-70 | 15-10 | .600 | - | ESPN2 | UD Arena · Dayton, OH |
| 26 | Wed Feb 18 | vsRichmond | W65-63 | 16-10 | .615 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 27 | Sat Feb 21 | atFordham | L59-63 | 16-11 | .593 | - | ESPN+ | Rose Hill Gymnasium · Bronx, NY |
| 28 | Wed Feb 25 | atDuquesne | W67-56 | 17-11 | .607 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 29 | Sun Mar 1 | vsLa Salle | W71-64 | 18-11 | .621 | - | USA Net | John M. Belk Arena · Davidson, NC |
