| 1 | Mon Nov 6 | vs TBD | W86-63 | 1-0 | 1.000 | - | | John M. Belk Arena · Davidson, NC |
| 2 | Fri Nov 10 | vs Maryland | W64-61 | 2-0 | 1.000 | - | ESPNU | John M. Belk Arena · Davidson, NC |
| 3 | Sun Nov 12 | at Clemson | L65-68 | 2-1 | .667 | - | ESPN2 | Littlejohn Coliseum · Clemson, SC |
| 4 | Fri Nov 17 | at ETSU | L68-70 | 2-2 | .500 | - | | Freedom Hall Civic Center · Johnson City, TN |
| 5 | Tue Nov 21 | vs Boston Univ | W69-45 | 3-2 | .600 | - | | John M. Belk Arena · Davidson, NC |
| 6 | Fri Nov 24 | at Saint Mary's | L55-89 | 3-3 | .500 | - | | University Credit Union Pavilion · Moraga, CA |
| 7 | Wed Nov 29 | at Charlotte | W85-81 | 4-3 | .571 | - | | Dale F. Halton Arena · Charlotte, NC |
| 8 | Sat Dec 2 | vs Wright St | W82-73 | 5-3 | .625 | - | | John M. Belk Arena · Davidson, NC |
| 9 | Wed Dec 6 | vs Campbell | W62-50 | 6-3 | .667 | - | | John M. Belk Arena · Davidson, NC |
| 10 | Sat Dec 9 | vs Miami OH | W79-61 | 7-3 | .700 | - | | John M. Belk Arena · Davidson, NC |
| 11 | Sat Dec 16 | vsTBD | W98-63 | 8-3 | .727 | - | | John M. Belk Arena · Davidson, NC |
| 12 | Thu Dec 21 | vs SC Upstate | W62-59 | 9-3 | .750 | - | | John M. Belk Arena · Davidson, NC |
| 13 | Sat Dec 30 | at Ohio | W72-69 | 10-3 | .769 | - | | Convocation Center (OH) · Athens, OH |
| 14 | Wed Jan 3 | vs Dayton | L59-72 | 10-4 | .714 | - | CBS | John M. Belk Arena · Davidson, NC |
| 15 | Tue Jan 9 | vs Rhode Island | L74-79 | 10-5 | .667 | - | | John M. Belk Arena · Davidson, NC |
| 16 | Sat Jan 13 | at G Washington | L79-83 (OT) | 10-6 | .625 | - | | Charles E. Smith Center · Washington, D.C. |
| 17 | Wed Jan 17 | at Fordham | W79-69 | 11-6 | .647 | - | | Rose Hill Gymnasium · Bronx, NY |
| 18 | Sat Jan 20 | vs Richmond | L64-69 (OT) | 11-7 | .611 | - | | John M. Belk Arena · Davidson, NC |
| 19 | Wed Jan 24 | at Saint Louis | W84-61 | 12-7 | .632 | - | | Chaifetz Arena · St. Louis, MO |
| 20 | Sat Jan 27 | vs VCU | L58-63 | 12-8 | .600 | - | CBS | John M. Belk Arena · Davidson, NC |
| 21 | Sun Feb 4 | at Loyola Chicago | L63-76 | 12-9 | .571 | - | CBS | Joseph J. Gentile Arena · Chicago, IL |
| 22 | Wed Feb 7 | at Duquesne | W72-59 | 13-9 | .591 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 23 | Sat Feb 10 | vs George Mason | L55-57 | 13-10 | .565 | - | USA Net | John M. Belk Arena · Davidson, NC |
| 24 | Tue Feb 13 | vs La Salle | W71-56 | 14-10 | .583 | - | | John M. Belk Arena · Davidson, NC |
| 25 | Sat Feb 17 | at St Bonaventure | L80-81 (OT) | 14-11 | .560 | - | CBS | Reilly Center · Saint Bonaventure, NY |
| 26 | Tue Feb 20 | vsFordham | W68-53 | 15-11 | .577 | - | | John M. Belk Arena · Davidson, NC |
| 27 | Sat Feb 24 | atRichmond | L63-66 | 15-12 | .556 | - | | Robins Center · Richmond, VA |
| 28 | Tue Feb 27 | at#21Dayton | L66-80 | 15-13 | .536 | - | CBS | UD Arena · Dayton, OH |
| 29 | Sat Mar 2 | vs UMass | L67-69 | 15-14 | .517 | - | USA Net | John M. Belk Arena · Davidson, NC |
| 30 | Wed Mar 6 | vsLoyola Chicago | L59-69 | 15-15 | .500 | - | | John M. Belk Arena · Davidson, NC |
| 31 | Sat Mar 9 | at Saint Joseph's | L71-89 | 15-16 | .484 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 32 | Tue Mar 12 | atFordham | L63-71 (OT) | 15-17 | .469 | - | | Rose Hill Gymnasium · Bronx, NY |
