| 1 | Wed Nov 6 | at 9UNC | L65-76 | +9½ | 0-1 | .000 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 2 | Sat Nov 9 | vsRobert Morris | W92-57 | -21 | 1-1 | .500 | - | | Purcell Pavilion · South Bend, IN |
| 3 | Tue Nov 12 | vsHoward | W79-50 | -29 | 2-1 | .667 | - | | Purcell Pavilion · South Bend, IN |
| 4 | Fri Nov 15 | vsMarshall | W74-64 | -19 | 3-1 | .750 | - | | Purcell Pavilion · South Bend, IN |
| 5 | Mon Nov 18 | vsPresbyterian | W63-53 | -27 | 4-1 | .800 | - | | Purcell Pavilion · South Bend, IN |
| 6 | Thu Nov 21 | vsToledo | W64-62 (OT) | -8 | 5-1 | .833 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 7 | Tue Nov 26 | vsFairleigh | W91-66 | -21½ | 6-1 | .857 | - | | Purcell Pavilion · South Bend, IN |
| 8 | Wed Dec 4 | atMaryland | L51-72 | +9½ | 6-2 | .750 | - | ESPN | XFINITY Center · College Park, MD |
| 9 | Sat Dec 7 | vsBoston College | L72-73 | -12½ | 6-3 | .667 | - | ESPNU | Purcell Pavilion · South Bend, IN |
| 10 | Tue Dec 10 | vsDetroit Mercy | W110-71 | -19½ | 7-3 | .700 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 11 | Sat Dec 14 | vsUCLA | W75-61 | -6 | 8-3 | .727 | - | ABC | Purcell Pavilion · South Bend, IN |
| 12 | Sat Dec 21 | atIndiana | L60-62 | +2½ | 8-4 | .667 | - | ESPN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 13 | Sun Dec 29 | vsAlabama A&M | W82-56 | -25½ | 9-4 | .692 | - | | Purcell Pavilion · South Bend, IN |
| 14 | Sat Jan 4 | atSyracuse | W88-87 | +3½ | 10-4 | .714 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 15 | Wed Jan 8 | atNC State | L68-73 | +2½ | 10-5 | .667 | - | ESPN2 | Lenovo Center · Raleigh, NC |
| 16 | Sat Jan 11 | vs13Louisville | L64-67 | +3½ | 10-6 | .625 | - | ESPN | Purcell Pavilion · South Bend, IN |
| 17 | Wed Jan 15 | atGeorgia Tech | W78-74 | +1½ | 11-6 | .647 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 18 | Wed Jan 22 | vsSyracuse | L82-84 | -4½ | 11-7 | .611 | - | ESPN2 | Purcell Pavilion · South Bend, IN |
| 19 | Sat Jan 25 | at5Florida St | L84-85 | +9 | 11-8 | .579 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 20 | Wed Jan 29 | vsWake Forest | W90-80 | -9 | 12-8 | .600 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 21 | Sat Feb 1 | vsGeorgia Tech | W80-72 | -7 | 13-8 | .619 | - | | Purcell Pavilion · South Bend, IN |
| 22 | Wed Feb 5 | vsPitt | W80-72 | -6 | 14-8 | .636 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 23 | Sun Feb 9 | atClemson | W61-57 | -2 | 15-8 | .652 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 24 | Tue Feb 11 | atVirginia | L49-50 (OT) | +5 | 15-9 | .625 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 25 | Sat Feb 15 | at7Duke | L60-94 | +12½ | 15-10 | .600 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 26 | Mon Feb 17 | vsUNC | W77-76 | -4½ | 16-10 | .615 | - | ESPN | Purcell Pavilion · South Bend, IN |
| 27 | Sun Feb 23 | vsMiami | W87-71 | -7 | 17-10 | .630 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 28 | Wed Feb 26 | atBoston College | W62-61 | -5½ | 18-10 | .643 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 29 | Sat Feb 29 | atWake Forest | L73-84 | -1½ | 18-11 | .621 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 30 | Wed Mar 4 | vs7Florida St | L71-73 | +1½ | 18-12 | .600 | - | ESPN2 | Purcell Pavilion · South Bend, IN |
| 31 | Sat Mar 7 | vsVirginia Tech | W64-56 | -7½ | 19-12 | .613 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 32 | Wed Mar 11 | vsBoston College | W80-58 | -10½ | 20-12 | .625 | - | ESPN2 | Greensboro Coliseum · Greensboro, NC |
