| 1 | Thu Nov 10 | vs Radford | W79-76 | -18½ | 1-0 | 1.000 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 2 | Sun Nov 13 | vs Youngstown St | W88-81 | -10½ | 2-0 | 1.000 | - | | Purcell Pavilion · South Bend, IN |
| 3 | Wed Nov 16 | vs So Indiana | W82-70 | -15 | 3-0 | 1.000 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 4 | Fri Nov 18 | vs Lipscomb | W66-65 | -12½ | 4-0 | 1.000 | - | | Purcell Pavilion · South Bend, IN |
| 5 | Tue Nov 22 | vs Bowling Green | W82-66 | -16 | 5-0 | 1.000 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 6 | Fri Nov 25 | at St Bonaventure | L51-63 | -6 | 5-1 | .833 | - | | Reilly Center · Saint Bonaventure, NY |
| 7 | Wed Nov 30 | vs Michigan St | W70-52 | +1½ | 6-1 | .857 | - | ESPN2 | Purcell Pavilion · South Bend, IN |
| 8 | Sat Dec 3 | vs Syracuse | L61-62 | -6½ | 6-2 | .750 | - | ESPN2 | Purcell Pavilion · South Bend, IN |
| 9 | Wed Dec 7 | vs Boston Univ | W81-75 | -14 | 7-2 | .778 | - | | Purcell Pavilion · South Bend, IN |
| 10 | Sun Dec 11 | vs Marquette | L64-79 | +1½ | 7-3 | .700 | - | ESPN2 | Purcell Pavilion · South Bend, IN |
| 11 | Sun Dec 18 | at Georgia | L62-77 | -3½ | 7-4 | .636 | - | ESPN2 | State Farm Arena · Atlanta, GA |
| 12 | Wed Dec 21 | at Florida St | L72-73 | -1½ | 7-5 | .583 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 13 | Tue Dec 27 | vs Jacksonville | W59-43 | -8 | 8-5 | .615 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 14 | Fri Dec 30 | vs 14Miami | L65-76 | +2½ | 8-6 | .571 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 15 | Tue Jan 3 | at Boston College | L63-70 | -2½ | 8-7 | .533 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 16 | Sat Jan 7 | at UNC | L64-81 | +12½ | 8-8 | .500 | - | ESPN2 | Dean E. Smith Center · Chapel Hill, NC |
| 17 | Tue Jan 10 | vs Georgia Tech | W73-72 (OT) | -5 | 9-8 | .529 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 18 | Sat Jan 14 | at Syracuse | L73-78 | +5½ | 9-9 | .500 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 19 | Tue Jan 17 | vs Florida St | L71-84 | -4½ | 9-10 | .474 | - | ESPNU | Purcell Pavilion · South Bend, IN |
| 20 | Sat Jan 21 | vs Boston College | L72-84 | -5 | 9-11 | .450 | - | | Purcell Pavilion · South Bend, IN |
| 21 | Tue Jan 24 | at NC State | L82-85 | +9 | 9-12 | .429 | - | ACC Network | Lenovo Center · Raleigh, NC |
| 22 | Sat Jan 28 | vs Louisville | W76-62 | -9½ | 10-12 | .455 | - | ESPN2 | Purcell Pavilion · South Bend, IN |
| 23 | Sat Feb 4 | vs Wake Forest | L64-81 | +3 | 10-13 | .435 | - | | Purcell Pavilion · South Bend, IN |
| 24 | Wed Feb 8 | at Georgia Tech | L68-70 | -1 | 10-14 | .417 | - | | McCamish Pavilion · Atlanta, GA |
| 25 | Sat Feb 11 | vs Virginia Tech | L87-93 | +5½ | 10-15 | .400 | - | | Purcell Pavilion · South Bend, IN |
| 26 | Tue Feb 14 | at Duke | L64-68 | +12 | 10-16 | .385 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 27 | Sat Feb 18 | at 7Virginia | L55-57 | +12½ | 10-17 | .370 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 28 | Wed Feb 22 | vs UNC | L59-63 | +6½ | 10-18 | .357 | - | ESPN | Purcell Pavilion · South Bend, IN |
| 29 | Sat Feb 25 | at Wake Forest | L58-66 | +7½ | 10-19 | .345 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 30 | Wed Mar 1 | vs 25Pitt | W88-81 | +3½ | 11-19 | .367 | - | ESPNU | Purcell Pavilion · South Bend, IN |
| 31 | Sat Mar 4 | at Clemson | L64-87 | +9½ | 11-20 | .355 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 32 | Tue Mar 7 | at Virginia Tech | L64-67 | +6½ | 11-21 | .344 | - | ACC Network | Greensboro Coliseum · Greensboro, NC |