| 1 | Mon Nov 3 | vs Long Island | W89-67 | - | 1-0 | 1.000 | - | | Purcell Pavilion · South Bend, IN |
| 2 | Fri Nov 7 | vsDetroit Mercy | W102-70 | - | 2-0 | 1.000 | - | | Purcell Pavilion · South Bend, IN |
| 3 | Tue Nov 11 | vsE Illinois | W78-58 | - | 3-0 | 1.000 | - | | Purcell Pavilion · South Bend, IN |
| 4 | Sun Nov 16 | atOhio State | L63-64 | - | 3-1 | .750 | - | FS1 | Value City Arena · Columbus, OH |
| 5 | Wed Nov 19 | vsBellarmine | W86-79 | - | 4-1 | .800 | - | | Purcell Pavilion · South Bend, IN |
| 6 | Mon Nov 24 | atKansas | L61-71 | +5½ | 4-2 | .667 | - | TNT | Allen Fieldhouse · Lawrence, KS |
| 7 | Tue Nov 25 | vsRutgers | W68-63 | -6½ | 5-2 | .714 | - | TNT | Purcell Pavilion · South Bend, IN |
| 8 | Wed Nov 26 | at3Houston | L56-66 | +11½ | 5-3 | .625 | - | TNT | Fertitta Center · Houston, TX |
| 9 | Tue Dec 2 | vsMissouri | W76-71 | +1½ | 6-3 | .667 | - | ESPNU | Purcell Pavilion · South Bend, IN |
| 10 | Fri Dec 5 | atTCU | W87-85 (OT) | +6½ | 7-3 | .700 | - | ESPN+ | Schollmaier Arena · Fort Worth, TX |
| 11 | Wed Dec 10 | vsIdaho | W80-65 | -11½ | 8-3 | .727 | - | | Purcell Pavilion · South Bend, IN |
| 12 | Sat Dec 13 | vsEvansville | W82-58 | -14½ | 9-3 | .750 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 13 | Sun Dec 21 | vsPurdue FW | L69-72 | -11½ | 9-4 | .692 | - | | Purcell Pavilion · South Bend, IN |
| 14 | Tue Dec 30 | atStanford | W47-40 | +6½ | 10-4 | .714 | - | ESPN2 | Maples Pavilion · Stanford, CA |
| 15 | Fri Jan 2 | atCalifornia | L71-72 | +3½ | 10-5 | .667 | - | ESPN2 | Haas Pavilion · Berkeley, CA |
| 16 | Sat Jan 10 | vsClemson | L61-76 | +3½ | 10-6 | .625 | - | ESPN2 | Purcell Pavilion · South Bend, IN |
| 17 | Tue Jan 13 | vsMiami | L69-81 | +5½ | 10-7 | .588 | - | ESPNU | Purcell Pavilion · South Bend, IN |
| 18 | Sat Jan 17 | atVirginia Tech | L76-89 | +6½ | 10-8 | .556 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 19 | Wed Jan 21 | at22UNC | L69-91 | +13½ | 10-9 | .526 | - | ESPN2 | Dean E. Smith Center · Chapel Hill, NC |
| 20 | Sat Jan 24 | vsBoston College | W68-64 | -7½ | 11-9 | .550 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 21 | Tue Jan 27 | vs17Virginia | L97-100 (2OT) | +9½ | 11-10 | .524 | - | ESPN2 | Purcell Pavilion · South Bend, IN |
| 22 | Sat Jan 31 | atSyracuse | L72-86 | +6½ | 11-11 | .500 | - | The CW | JMA Wireless Dome · Syracuse, NY |
| 23 | Wed Feb 4 | at24Louisville | L65-76 | +19½ | 11-12 | .478 | - | ESPN2 | KFC Yum! Center · Louisville, KY |
| 24 | Sat Feb 7 | vsFlorida St | L79-82 | -1½ | 11-13 | .458 | - | The CW | Purcell Pavilion · South Bend, IN |
| 25 | Tue Feb 10 | atSMU | L81-89 | +10½ | 11-14 | .440 | - | ACC Network | Moody Coliseum · Dallas, TX |
| 26 | Sat Feb 14 | vsGeorgia Tech | W89-74 | -5½ | 12-14 | .462 | - | The CW | Purcell Pavilion · South Bend, IN |
| 27 | Sat Feb 21 | atPitt | L68-73 | +3½ | 12-15 | .444 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 28 | Tue Feb 24 | vs1Duke | L56-100 | +16½ | 12-16 | .429 | - | ESPN | Purcell Pavilion · South Bend, IN |
| 29 | Sat Feb 28 | vsNC State | W96-90 (OT) | +6½ | 13-16 | .448 | - | The CW | Purcell Pavilion · South Bend, IN |
| 30 | Wed Mar 4 | vsStanford | L78-86 | +1½ | 13-17 | .433 | - | ESPNU | Purcell Pavilion · South Bend, IN |
| 31 | Sat Mar 7 | atBoston College | L69-77 | -1½ | 13-18 | .419 | - | ESPNU | Silvio O. Conte Forum · Chestnut Hill, MA |
