| 1 | Mon Nov 3 | vs Long Island | 7:00 PM | 17-16 | .515 | - | | Purcell Pavilion · South Bend, IN |
| 2 | Fri Nov 7 | vsDetroit Mercy | TBD | 8-24 | .250 | - | | Purcell Pavilion · South Bend, IN |
| 3 | Tue Nov 11 | vsE Illinois | TBD | 12-19 | .387 | - | | Purcell Pavilion · South Bend, IN |
| 4 | Sun Nov 16 | atOhio State | TBD | 17-15 | .531 | - | | Value City Arena · Columbus, OH |
| 5 | Wed Nov 19 | vsBellarmine | TBD | 5-26 | .161 | - | | Purcell Pavilion · South Bend, IN |
| 6 | Mon Nov 24 | at#19Kansas | 3:30 PM | 21-13 | .618 | - | TNT | Allen Fieldhouse · Lawrence, KS |
| 7 | Tue Nov 25 | vsRutgers | 1:00 PM | 15-17 | .469 | - | | Purcell Pavilion · South Bend, IN |
| 8 | Tue Dec 2 | vsMissouri | 9:00 PM | 22-12 | .647 | - | ESPNU | Purcell Pavilion · South Bend, IN |
| 9 | Fri Dec 5 | atTCU | 8:00 PM | 16-16 | .500 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 10 | Wed Dec 10 | vsIdaho | TBD | 14-19 | .424 | - | | Purcell Pavilion · South Bend, IN |
| 11 | Sat Dec 13 | vsEvansville | 2:00 PM | 11-21 | .344 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 12 | Sun Dec 21 | vsPurdue FW | TBD | 19-13 | .594 | - | | Purcell Pavilion · South Bend, IN |
| 13 | Tue Dec 30 | atStanford | 9:00 PM | 21-14 | .600 | - | ESPN2 | Maples Pavilion · Stanford, CA |
| 14 | Fri Jan 2 | atCalifornia | 11:00 PM | 14-19 | .424 | - | ESPN2 | Haas Pavilion · Berkeley, CA |
| 15 | Sat Jan 10 | vsClemson | 6:00 PM | 27-7 | .794 | - | ESPN2 | Purcell Pavilion · South Bend, IN |
| 16 | Tue Jan 13 | vsMiami | 7:00 PM | 7-24 | .226 | - | | Purcell Pavilion · South Bend, IN |
| 17 | Sat Jan 17 | atVirginia Tech | 12:00 PM | 13-19 | .406 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 18 | Wed Jan 21 | at#25UNC | 7:00 PM | 23-14 | .622 | - | ESPN2 | Dean E. Smith Center · Chapel Hill, NC |
| 19 | Sat Jan 24 | vsBoston College | 6:00 PM | 12-19 | .387 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 20 | Tue Jan 27 | vsVirginia | TBD | 15-17 | .469 | - | | Purcell Pavilion · South Bend, IN |
| 21 | Sat Jan 31 | atSyracuse | TBD | 14-19 | .424 | - | | JMA Wireless Dome · Syracuse, NY |
| 22 | Wed Feb 4 | at#11Louisville | 7:00 PM | 27-8 | .771 | - | ESPN2 | KFC Yum! Center · Louisville, KY |
| 23 | Sat Feb 7 | vsFlorida St | 4:00 PM | 17-15 | .531 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 24 | Tue Feb 10 | atSMU | 7:00 PM | 24-11 | .686 | - | ACC Network | Moody Coliseum · Dallas, TX |
| 25 | Sat Feb 14 | vsGeorgia Tech | TBD | 17-17 | .500 | - | | Purcell Pavilion · South Bend, IN |
| 26 | Sat Feb 21 | atPitt | 2:00 PM | 17-15 | .531 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 27 | Tue Feb 24 | vs#6Duke | TBD | 35-4 | .897 | - | | Purcell Pavilion · South Bend, IN |
| 28 | Sat Feb 28 | vsNC State | TBD | 12-19 | .387 | - | | Purcell Pavilion · South Bend, IN |
| 29 | Wed Mar 4 | vsStanford | 9:00 PM | 21-14 | .600 | - | ESPNU | Purcell Pavilion · South Bend, IN |
| 30 | Sat Mar 7 | atBoston College | 12:00 PM | 12-19 | .387 | - | ESPNU | Silvio O. Conte Forum · Chestnut Hill, MA |
