| 1 | Tue Nov 9 | vs Texas So | W83-66 | 1-0 | 1.000 | #13 | PACN | Matthew Knight Arena · Eugene, OR |
| 2 | Fri Nov 12 | vsSMU | W86-63 | 2-0 | 1.000 | #13 | PACN | Matthew Knight Arena · Eugene, OR |
| 3 | Tue Nov 16 | vsBYU | L49-81 | 2-1 | .667 | - | ESPN | Matthew Knight Arena · Eugene, OR |
| 4 | Mon Nov 22 | atTBD | W73-49 | 3-1 | .750 | - | ESPNU | Michelob ULTRA Arena |
| 5 | Tue Nov 23 | atSaint Mary's | L50-62 | 3-2 | .600 | - | ESPN | University Credit Union Pavilion · Moraga, CA |
| 6 | Wed Nov 24 | vsHouston | L49-78 | 3-3 | .500 | - | ESPN2 | Matthew Knight Arena · Eugene, OR |
| 7 | Mon Nov 29 | vsMontana | W87-47 | 4-3 | .571 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 8 | Wed Dec 1 | vsUC Riverside | W71-65 | 5-3 | .625 | - | | Matthew Knight Arena · Eugene, OR |
| 9 | Sun Dec 5 | vsArizona St | L67-69 (OT) | 5-4 | .556 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 10 | Sun Dec 12 | atStanford | L69-72 | 5-5 | .500 | - | PACN | Maples Pavilion · Stanford, CA |
| 11 | Wed Dec 15 | vsPortland | W96-71 | 6-5 | .545 | - | | Matthew Knight Arena · Eugene, OR |
| 12 | Sat Dec 18 | vs#1Baylor | L70-78 | 6-6 | .500 | - | ESPN2 | Matthew Knight Arena · Eugene, OR |
| 13 | Tue Dec 21 | vsPepperdine | W68-59 | 7-6 | .538 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 14 | Thu Dec 30 | vsColorado | PPD | 20-15 | .571 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 15 | Sat Jan 1 | vsUtah | W79-66 | 8-6 | .571 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 16 | Mon Jan 3 | vsColorado | PPD | 20-15 | .571 | - | | Matthew Knight Arena · Eugene, OR |
| 17 | Sat Jan 8 | atOregon St | PPD | 20-15 | .571 | - | | Gill Coliseum · Corvallis, OR |
| 18 | Mon Jan 10 | atOregon St | W78-76 | 9-6 | .600 | - | PACN | Gill Coliseum · Corvallis, OR |
| 19 | Thu Jan 13 | at#3UCLA | W84-81 (OT) | 10-6 | .625 | - | ESPN | Pauley Pavilion · Los Angeles, CA |
| 20 | Sat Jan 15 | at#5USC | W79-69 | 11-6 | .647 | - | FS1 | Galen Center · Los Angeles, CA |
| 21 | Thu Jan 20 | vsWashington St | PPD | 20-15 | .571 | - | | Matthew Knight Arena · Eugene, OR |
| 22 | Sun Jan 23 | vsWashington | W84-56 | 12-6 | .667 | - | | Matthew Knight Arena · Eugene, OR |
| 23 | Tue Jan 25 | vsColorado | L78-82 | 12-7 | .632 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 24 | Sat Jan 29 | vsOregon St | W78-56 | 13-7 | .650 | - | ESPN2 | Matthew Knight Arena · Eugene, OR |
| 25 | Thu Feb 3 | atColorado | W66-51 | 14-7 | .667 | - | FS1 | CU Events Center · Boulder, CO |
| 26 | Sat Feb 5 | atUtah | W80-77 | 15-7 | .682 | - | FS1 | Jon M. Huntsman Center · Salt Lake City, UT |
| 27 | Thu Feb 10 | vsStanford | W68-60 | 16-7 | .696 | - | ESPN2 | Matthew Knight Arena · Eugene, OR |
| 28 | Sat Feb 12 | vsCalifornia | L64-78 | 16-8 | .667 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 29 | Mon Feb 14 | vsWashington St | W62-59 | 17-8 | .680 | - | ESPNU | Matthew Knight Arena · Eugene, OR |
| 30 | Thu Feb 17 | atArizona St | L57-81 | 17-9 | .654 | - | ESPN | Desert Financial Arena · Tempe, AZ |
| 31 | Sat Feb 19 | at#3Arizona | L81-84 | 17-10 | .630 | - | ESPN | McKale Center · Tucson, AZ |
| 32 | Thu Feb 24 | vs#12UCLA | W68-63 | 18-10 | .643 | - | ESPN | Matthew Knight Arena · Eugene, OR |
| 33 | Sat Feb 26 | vs#16USC | L69-70 | 18-11 | .621 | - | ESPN2 | Matthew Knight Arena · Eugene, OR |
| 34 | Thu Mar 3 | atWashington | L67-78 | 18-12 | .600 | - | | Alaska Airlines Arena · Seattle, WA |
| 35 | Sat Mar 5 | atWashington St | L74-94 | 18-13 | .581 | - | CBS | Friel Court at Beasley Coliseum · Pullman, WA |
| 36 | Wed Mar 9 | vsOregon St | W86-72 | 19-13 | .594 | - | PACN | T-Mobile Arena · Las Vegas, NV |
| 37 | Thu Mar 10 | atColorado | L69-80 | 19-14 | .576 | - | PACN | T-Mobile Arena · Las Vegas, NV |
| 38 | Tue Mar 15 | atUtah State | W83-72 | 20-14 | .588 | - | ESPN | Dee Glen Smith Spectrum · Logan, UT |
| 39 | Sat Mar 19 | atTexas A&M | L60-75 | 20-15 | .571 | - | ESPN | Reed Arena · College Station, TX |
