| 1 | Mon Nov 7 | vs FAMU | W80-45 | 1-0 | 1.000 | - | | Matthew Knight Arena · Eugene, OR |
| 2 | Fri Nov 11 | vs UC Irvine | L56-69 | 1-1 | .500 | #21 | | Matthew Knight Arena · Eugene, OR |
| 3 | Tue Nov 15 | vs Montana St | W81-51 | 2-1 | .667 | - | | Matthew Knight Arena · Eugene, OR |
| 4 | Sun Nov 20 | vs #3Houston | L56-66 | 2-2 | .500 | - | ESPN | Matthew Knight Arena · Eugene, OR |
| 5 | Thu Nov 24 | vs UConn | L59-83 | 2-3 | .400 | - | ESPN2 | Matthew Knight Arena · Eugene, OR |
| 6 | Fri Nov 25 | at Michigan St | L70-74 | 2-4 | .333 | - | ESPN2 | Breslin Center · East Lansing, MI |
| 7 | Sun Nov 27 | vs Villanova | W74-67 | 3-4 | .429 | - | ESPN2 | Matthew Knight Arena · Eugene, OR |
| 8 | Thu Dec 1 | vs Washington St | W74-60 | 4-4 | .500 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 9 | Sun Dec 4 | at #21UCLA | L56-65 | 4-5 | .444 | - | ESPN | Pauley Pavilion · Los Angeles, CA |
| 10 | Sat Dec 10 | vs Nevada | W78-65 | 5-5 | .500 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 11 | Wed Dec 14 | vs UC Riverside | W71-65 | 6-5 | .545 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 12 | Sat Dec 17 | vs Portland | W78-56 | 7-5 | .583 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 13 | Tue Dec 20 | vs Utah Valley | L72-77 | 7-6 | .538 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 14 | Sat Dec 31 | vs Oregon St | W77-68 | 8-6 | .571 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 15 | Thu Jan 5 | at Colorado | L41-68 | 8-7 | .533 | - | ESPN2 | CU Events Center · Boulder, CO |
| 16 | Sat Jan 7 | at Utah | W70-60 | 9-7 | .563 | - | PACN | Jon M. Huntsman Center · Salt Lake City, UT |
| 17 | Thu Jan 12 | vs Arizona St | L73-90 | 9-8 | .529 | - | FS1 | Matthew Knight Arena · Eugene, OR |
| 18 | Sat Jan 14 | vs #9Arizona | W87-68 | 10-8 | .556 | - | ESPN | Matthew Knight Arena · Eugene, OR |
| 19 | Wed Jan 18 | at California | W87-58 | 11-8 | .579 | - | PACN | Haas Pavilion · Berkeley, CA |
| 20 | Sat Jan 21 | at Stanford | L64-71 | 11-9 | .550 | - | FS1 | Maples Pavilion · Stanford, CA |
| 21 | Thu Jan 26 | vsColorado | W75-69 | 12-9 | .571 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 22 | Sat Jan 28 | vsUtah | W68-56 | 13-9 | .591 | - | | Matthew Knight Arena · Eugene, OR |
| 23 | Thu Feb 2 | at#5Arizona | L76-91 | 13-10 | .565 | - | ESPN | McKale Center · Tucson, AZ |
| 24 | Sat Feb 4 | atArizona St | W75-70 | 14-10 | .583 | - | ESPN2 | Desert Financial Arena · Tempe, AZ |
| 25 | Thu Feb 9 | vs USC | W78-60 | 15-10 | .600 | - | ESPN2 | Matthew Knight Arena · Eugene, OR |
| 26 | Sat Feb 11 | vs#7UCLA | L63-70 | 15-11 | .577 | - | ESPN | Matthew Knight Arena · Eugene, OR |
| 27 | Wed Feb 15 | at Washington | L71-72 (OT) | 15-12 | .556 | - | ESPNU | Alaska Airlines Arena · Seattle, WA |
| 28 | Sun Feb 19 | atWashington St | L65-68 | 15-13 | .536 | - | FS1 | Friel Court at Beasley Coliseum · Pullman, WA |
| 29 | Sat Feb 25 | atOregon St | W69-67 | 16-13 | .552 | - | PACN | Gill Coliseum · Corvallis, OR |
| 30 | Thu Mar 2 | vsCalifornia | W84-51 | 17-13 | .567 | - | FS1 | Matthew Knight Arena · Eugene, OR |
| 31 | Sat Mar 4 | vsStanford | W73-68 | 18-13 | .581 | - | CBS | Matthew Knight Arena · Eugene, OR |
| 32 | Thu Mar 9 | vsWashington St | W75-70 | 19-13 | .594 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 33 | Fri Mar 10 | atUCLA | L56-75 | 19-14 | .576 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 34 | Wed Mar 15 | vsUC Irvine | W84-58 | 20-14 | .588 | - | ESPN2 | Matthew Knight Arena · Eugene, OR |
| 35 | Sun Mar 19 | vs UCF | W68-54 | 21-14 | .600 | - | ESPNU | Matthew Knight Arena · Eugene, OR |
| 36 | Tue Mar 21 | vs Wisconsin | L58-61 | 21-15 | .583 | - | ESPN | Matthew Knight Arena · Eugene, OR |
