| 1 | Mon Nov 6 | vs Georgia | W82-71 | 1-0 | 1.000 | - | truTV | Matthew Knight Arena · Eugene, OR |
| 2 | Fri Nov 10 | vs Montana | W75-61 | 2-0 | 1.000 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 3 | Fri Nov 17 | vs Tennessee St | W92-67 | 3-0 | 1.000 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 4 | Mon Nov 20 | at FAMU | W67-54 | 4-0 | 1.000 | - | | Al Lawson Center · Tallahassee, FL |
| 5 | Fri Nov 24 | vs Santa Clara | L82-88 | 4-1 | .800 | - | CBS | Matthew Knight Arena · Eugene, OR |
| 6 | Sat Nov 25 | vs #17Alabama | L91-99 | 4-2 | .667 | - | | Matthew Knight Arena · Eugene, OR |
| 7 | Sat Dec 2 | vs Michigan | W86-83 (OT) | 5-2 | .714 | - | FS1 | Matthew Knight Arena · Eugene, OR |
| 8 | Sat Dec 9 | vs UTEP | W71-49 | 6-2 | .750 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 9 | Tue Dec 12 | vs CA Baptist | W76-55 | 7-2 | .778 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 10 | Sun Dec 17 | vs Syracuse | L63-83 | 7-3 | .700 | - | CBS | Matthew Knight Arena · Eugene, OR |
| 11 | Thu Dec 21 | vs Kent State | W84-70 | 8-3 | .727 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 12 | Thu Dec 28 | vs USC | W82-74 | 9-3 | .750 | - | ESPN2 | Matthew Knight Arena · Eugene, OR |
| 13 | Sat Dec 30 | vs UCLA | W64-59 | 10-3 | .769 | - | CBS | Matthew Knight Arena · Eugene, OR |
| 14 | Thu Jan 4 | at Washington | W76-74 | 11-3 | .786 | - | PACN | Alaska Airlines Arena · Seattle, WA |
| 15 | Sat Jan 6 | at Washington St | W89-84 | 12-3 | .800 | - | ESPNU | Friel Court at Beasley Coliseum · Pullman, WA |
| 16 | Sat Jan 13 | vs California | W80-73 | 13-3 | .813 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 17 | Thu Jan 18 | at Colorado | L70-86 | 13-4 | .765 | - | FS1 | CU Events Center · Boulder, CO |
| 18 | Sun Jan 21 | at Utah | L77-80 | 13-5 | .722 | - | ESPN | Jon M. Huntsman Center · Salt Lake City, UT |
| 19 | Thu Jan 25 | vs Arizona St | W80-61 | 14-5 | .737 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 20 | Sat Jan 27 | vs #9Arizona | L78-87 | 14-6 | .700 | - | FOX | Matthew Knight Arena · Eugene, OR |
| 21 | Thu Feb 1 | atUSC | W78-69 | 15-6 | .714 | - | ESPN | Galen Center · Los Angeles, CA |
| 22 | Sat Feb 3 | atUCLA | L63-71 | 15-7 | .682 | - | ESPN2 | Pauley Pavilion · Los Angeles, CA |
| 23 | Thu Feb 8 | vsWashington | W85-80 | 16-7 | .696 | - | FS1 | Matthew Knight Arena · Eugene, OR |
| 24 | Sat Feb 10 | vsWashington St | L56-62 | 16-8 | .667 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 25 | Sat Feb 17 | at Oregon St | W60-58 | 17-8 | .680 | - | PACN | Gill Coliseum · Corvallis, OR |
| 26 | Thu Feb 22 | at Stanford | W78-65 | 18-8 | .692 | - | ESPN2 | Maples Pavilion · Stanford, CA |
| 27 | Sat Feb 24 | atCalifornia | L64-69 | 18-9 | .667 | - | PACN | Haas Pavilion · Berkeley, CA |
| 28 | Wed Feb 28 | vsOregon St | W78-71 | 19-9 | .679 | - | FS1 | Matthew Knight Arena · Eugene, OR |
| 29 | Sat Mar 2 | at#6Arizona | L83-103 | 19-10 | .655 | - | ESPN | McKale Center · Tucson, AZ |
| 30 | Thu Mar 7 | vsColorado | L75-79 | 19-11 | .633 | - | ESPN2 | Matthew Knight Arena · Eugene, OR |
| 31 | Sat Mar 9 | vsUtah | W66-65 | 20-11 | .645 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 32 | Thu Mar 14 | vsUCLA | W68-66 | 21-11 | .656 | - | PACN | Matthew Knight Arena · Eugene, OR |
| 33 | Fri Mar 15 | at#6Arizona | W67-59 | 22-11 | .667 | - | PACN | McKale Center · Tucson, AZ |
| 34 | Sat Mar 16 | atColorado | W75-68 | 23-11 | .676 | - | FOX | CU Events Center · Boulder, CO |
| 35 | Thu Mar 21 | at #6South Carolina | W87-73 | 24-11 | .686 | #11 | TNT | Colonial Life Arena · Columbia, SC |
| 36 | Sat Mar 23 | at #3Creighton | L73-86 (2OT) | 24-12 | .667 | #11 | TBS | CHI Health Center Omaha · Omaha, NE |
