| 1 | Wed Nov 25 | vs Sacred Heart | W86-63 | 1-0 | 1.000 | #24 | | Jersey Mike’s Arena · Piscataway, NJ |
| 2 | Fri Nov 27 | vsFairleigh | W96-75 | 2-0 | 1.000 | #24 | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 3 | Sun Nov 29 | vsHofstra | W70-56 | 3-0 | 1.000 | #24 | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 4 | Tue Dec 8 | vsSyracuse | W79-69 | 4-0 | 1.000 | - | ESPN2 | Jersey Mike’s Arena · Piscataway, NJ |
| 5 | Mon Dec 14 | atMaryland | W74-60 | 5-0 | 1.000 | #19 | BTN | XFINITY Center · College Park, MD |
| 6 | Sun Dec 20 | vs13Illinois | W91-88 | 6-0 | 1.000 | #19 | ESPN2 | Jersey Mike’s Arena · Piscataway, NJ |
| 7 | Wed Dec 23 | at23Ohio State | L68-80 | 6-1 | .857 | #11 | BTN | Value City Arena · Columbus, OH |
| 8 | Tue Dec 29 | vsPurdue | W81-76 | 7-1 | .875 | #14 | FS1 | Jersey Mike’s Arena · Piscataway, NJ |
| 9 | Sat Jan 2 | vs10Iowa | L75-77 | 7-2 | .778 | #14 | ESPN2 | Jersey Mike’s Arena · Piscataway, NJ |
| 10 | Tue Jan 5 | at23Michigan St | L45-68 | 7-3 | .700 | #15 | ESPN2 | Breslin Center · East Lansing, MI |
| 11 | Sat Jan 9 | vsOhio State | L68-79 | 7-4 | .636 | #15 | | Jersey Mike’s Arena · Piscataway, NJ |
| 12 | Tue Jan 12 | atPenn State | PPD | 16-12 | .571 | - | BTN | Bryce Jordan Center · University Park, PA |
| 13 | Fri Jan 15 | vs9Wisconsin | L54-60 | 7-5 | .583 | - | | Jersey Mike’s Arena · Piscataway, NJ |
| 14 | Thu Jan 21 | atPenn State | L67-75 | 7-6 | .538 | - | BTN | Bryce Jordan Center · University Park, PA |
| 15 | Sun Jan 24 | atIndiana | W74-70 | 8-6 | .571 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 16 | Thu Jan 28 | vsMichigan St | W67-37 | 9-6 | .600 | - | FS1 | Jersey Mike’s Arena · Piscataway, NJ |
| 17 | Sun Jan 31 | atNorthwestern | W64-56 | 10-6 | .625 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 18 | Thu Feb 4 | vsMinnesota | W76-72 | 11-6 | .647 | - | FS1 | Jersey Mike’s Arena · Piscataway, NJ |
| 19 | Wed Feb 10 | at15Iowa | L66-79 | 11-7 | .611 | #25 | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 20 | Sat Feb 13 | vsNorthwestern | W64-50 | 12-7 | .632 | #25 | | Jersey Mike’s Arena · Piscataway, NJ |
| 21 | Thu Feb 18 | at3Michigan | L64-71 | 12-8 | .600 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 22 | Sun Feb 21 | vsMaryland | L59-68 | 12-9 | .571 | - | | Jersey Mike’s Arena · Piscataway, NJ |
| 23 | Wed Feb 24 | vsIndiana | W74-63 | 13-9 | .591 | - | | Jersey Mike’s Arena · Piscataway, NJ |
| 24 | Mon Mar 1 | atNebraska | L51-72 | 13-10 | .565 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 25 | Sat Mar 6 | atMinnesota | W77-70 (OT) | 14-10 | .583 | - | FOX | Williams Arena · Minneapolis, MN |
| 26 | Thu Mar 11 | vsIndiana | W61-50 | 15-10 | .600 | - | BTN | Lucas Oil Stadium · Indianapolis, IN |
| 27 | Fri Mar 12 | atIllinois | L68-90 | 15-11 | .577 | - | BTN | Lucas Oil Stadium · Indianapolis, IN |
| 28 | Fri Mar 19 | at7Clemson | W60-56 | 16-11 | .593 | #10 | TBS | Littlejohn Coliseum · Clemson, SC |
| 29 | Sun Mar 21 | at2Houston | L60-63 | 16-12 | .571 | #10 | TBS | Lucas Oil Stadium · Indianapolis, IN |
