| 1 | Mon Nov 6 | vs TBD | W88-57 | 1-0 | 1.000 | - | | Banterra Center · Carbondale, IL |
| 2 | Fri Nov 10 | vsQueens | W91-68 | 2-0 | 1.000 | - | | Banterra Center · Carbondale, IL |
| 3 | Thu Nov 16 | vsChicago St | W71-55 | 3-0 | 1.000 | - | | Banterra Center · Carbondale, IL |
| 4 | Tue Nov 21 | vs#22JMU | L76-82 | 3-1 | .750 | - | CBS | Banterra Center · Carbondale, IL |
| 5 | Wed Nov 22 | atNew Mexico St | W81-54 | 4-1 | .800 | - | | Pan American Center · Las Cruces, NM |
| 6 | Tue Nov 28 | atIndiana St | L48-77 | 4-2 | .667 | - | | Hulman Center · Terre Haute, IN |
| 7 | Sat Dec 2 | vsSaint Louis | W101-62 | 5-2 | .714 | - | | Banterra Center · Carbondale, IL |
| 8 | Tue Dec 5 | vsOklahoma St | W70-68 | 6-2 | .750 | - | CBS | Banterra Center · Carbondale, IL |
| 9 | Tue Dec 12 | vsAustin Peay | L68-70 | 6-3 | .667 | - | | Banterra Center · Carbondale, IL |
| 10 | Sat Dec 16 | atWichita St | L68-69 | 6-4 | .600 | - | | Charles Koch Arena · Wichita, KS |
| 11 | Tue Dec 19 | vsN Dakota St | W76-63 | 7-4 | .636 | - | | Banterra Center · Carbondale, IL |
| 12 | Fri Dec 22 | vsSo Indiana | W81-50 | 8-4 | .667 | - | | Banterra Center · Carbondale, IL |
| 13 | Sat Dec 30 | vsUIC | W62-50 | 9-4 | .692 | - | | Banterra Center · Carbondale, IL |
| 14 | Tue Jan 2 | vsBelmont | W73-63 | 10-4 | .714 | - | | Banterra Center · Carbondale, IL |
| 15 | Sat Jan 6 | atIllinois St | W71-64 | 11-4 | .733 | - | | Redbird Arena · Normal, IL |
| 16 | Wed Jan 10 | atValparaiso | W77-68 | 12-4 | .750 | - | | Athletics-Recreation Center · Valparaiso, IN |
| 17 | Sat Jan 13 | vsDrake | L58-76 | 12-5 | .706 | - | ESPN2 | Banterra Center · Carbondale, IL |
| 18 | Wed Jan 17 | vsBradley | L69-70 | 12-6 | .667 | - | | Banterra Center · Carbondale, IL |
| 19 | Sat Jan 20 | atNorthern Iowa | L57-61 | 12-7 | .632 | - | CBS | McLeod Center · Cedar Falls, IA |
| 20 | Wed Jan 24 | vsValparaiso | W75-69 | 13-7 | .650 | - | | Banterra Center · Carbondale, IL |
| 21 | Sat Jan 27 | atMurray St | W60-58 | 14-7 | .667 | - | | CFSB Center · Murray, KY |
| 22 | Wed Jan 31 | vsMissouri St | L75-76 (OT) | 14-8 | .636 | - | | Banterra Center · Carbondale, IL |
| 23 | Sat Feb 3 | atUIC | W74-71 | 15-8 | .652 | - | | Credit Union 1 Arena · Chicago, IL |
| 24 | Wed Feb 7 | atDrake | L88-92 (OT) | 15-9 | .625 | - | | The Knapp Center · Des Moines, IA |
| 25 | Sat Feb 10 | vsIllinois St | W69-66 | 16-9 | .640 | - | | Banterra Center · Carbondale, IL |
| 26 | Wed Feb 14 | atBelmont | L68-82 | 16-10 | .615 | - | | Curb Event Center Arena · Nashville, TN |
| 27 | Sat Feb 17 | vs#23Indiana St | W74-69 | 17-10 | .630 | - | | Banterra Center · Carbondale, IL |
| 28 | Wed Feb 21 | vsMurray St | W72-68 | 18-10 | .643 | - | | Banterra Center · Carbondale, IL |
| 29 | Sun Feb 25 | atEvansville | W65-53 | 19-10 | .655 | - | | Ford Center · Evansville, IN |
| 30 | Wed Feb 28 | atBradley | L67-86 | 19-11 | .633 | - | | Carver Arena · Peoria, IL |
| 31 | Sun Mar 3 | vsNorthern Iowa | L70-82 | 19-12 | .613 | - | | Banterra Center · Carbondale, IL |
| 32 | Thu Mar 7 | vsUIC | L82-84 (2OT) | 19-13 | .594 | - | | Banterra Center · Carbondale, IL |
